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TranscriptomicsGene Expression Profiling of siRNA Knock-Down of Six1, Six4 and Myogenin in C2C12
Six1, Six4 and Myogenin are transcription factors that are known to be required for skeletal myogenesis. Currently, very little is known about the genes targeted by Six1 and Six4. Gene expression profiling when one or both transcription factors were knock-down by siRNA was performed to identify gene...
ORGANISM(S): Mus musculus 
2010-07-30 | E-GEOD-19967 | biostudies-arrayexpress
GenomicsIntegrative analysis of the zinc finger transcription factor Lame duck in the Drosophila myogenic gene regulatory network
Contemporary high throughput technologies permit the rapid identification of transcription factor (TF) target genes on a genome-wide scale, yet the functional significance of TFs requires knowledge of target gene expression patterns, cooperating TFs and cis-regulatory element (CRE) structures. Here...
ORGANISM(S): Drosophila melanogaster 
2012-11-13 | E-GEOD-38402 | biostudies-arrayexpress
TranscriptomicsmiR-487b, miR-3963 and miR-6412 delayed myogenic differentiation in C2C12 mouse myoblast-derived cells.
We newly identified skeletal muscle differentiation-associated miRNAs by comparing miRNA expression profile between C2C12 cell and Wnt4-overexpressing C2C12 cell. miR-487b, miR-3963 and miR-6412 are significantly down-regulated in differentiating C2C12 cells, and transfection of their mimics result...
ORGANISM(S): Mus musculus 
2015-11-24 | E-GEOD-63454 | biostudies-arrayexpress
TranscriptomicsEnhanced MyoD-Induced Transdifferentiation to a Myogenic Lineage by Fusion to a Potent Transactivation Domain
Synthetic transcription factors can be applied to many areas of biotechnology, medicine, and basic research.  Currently, the most common method for engineering synthetic transcription factors has been based on programmable DNA-binding domains of zinc finger proteins, Transcription Activator-Like Ef...
ORGANISM(S): Homo sapiens 
2014-12-11 | E-GEOD-62448 | biostudies-arrayexpress
TranscriptomicsGenomic mapping of Six1 binding sites during skeletal myoblast differentiation
In this study, the C2C12 cell line, a model used to study myogenesis and regeneration, was allowed to differentiate from myoblast precursor cells to myotubes. Cells were harvested at 3 different timepoints to perform ChIP-on-Chip of Six1, which is a key muscle regulator. We identified global loci bo...
ORGANISM(S): Mus musculus 
2010-07-05 | E-GEOD-20150 | biostudies-arrayexpress
UnknownMyogenic regulatory transcription factors regulate growth in rhabdomyosarcoma.
Not available
S-EPMC5231408 | biostudies-literature
GenomicsSix1 orchestrates tongue muscle differentiation by modulating core myogenic transcription factors [CUT&Tag]
Six1 orchestrates tongue muscle differentiation by modulating core myogenic transcription factors [CUT&Tag]
PRJNA1329205 | ENA
GenomicsSix1 orchestrates tongue muscle differentiation by modulating core myogenic transcription factors [RNA-seq]
Six1 orchestrates tongue muscle differentiation by modulating core myogenic transcription factors [RNA-seq]
PRJNA1329208 | ENA
UnknownCooperation between myogenic regulatory factors and SIX family transcription factors is important for myoblast differentiation.
Not available
S-EPMC2978361 | biostudies-literature
UnknownMethylmercury modifies temporally expressed myogenic regulatory factors to inhibit myoblast differentiation.
Not available
S-EPMC7027433 | biostudies-literature
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