nerve repair - OmicsDI

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Single-Cell Extraction: For enzymatic digestion, pronase (Septomyces argeus, 1 mg/mL) was applied for 25 minutes at room temperature for P0 to P8 datasets. Cells were dissociated and triturated into a single-cell suspension in ACSF supplemented with 1% fetal calf serum (FCS) and DNase (1 µL/10 mL). Trituration was performed using three glass Pasteur pipettes of decreasing diameters. For P30 datasets, enzymatic digestion and cell dissociation were carried out using the Worthington Papain Dissociation System, following the manufacturer’s instructions. Single-Nuclei Extraction: For nuclei isolation, the Hibernate™-E Medium was removed, and 500 µL of chilled 0.1X NP40 Lysis Buffer was added. Tissue was homogenized using a Pellet Pestle (15 strokes) and incubated on ice for 5 minutes. The suspension was pipette-mixed 10 times using a wide-bore pipette tip and incubated for an additional 10 minutes on ice. Following lysis, 500 µL of chilled wash buffer was added, and the mixture was pipette-mixed 5 times using a regular-bore pipette tip. The suspension was filtered through a 30 µm cell strainer into a 50 mL tube to remove debris. The filtered suspension was transferred to a 1.5 mL tube and centrifuged at 950 × g for 10 minutes at 4°C. The supernatant was carefully removed, and the nuclei pellet was retained for downstream analysis. (2)
Single cells were captured using the 10x Genomics Chromium Controller. (2)
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-- (1)
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Lab affiliation

Departement for Biomedical Research University of Bern Switzerland (1)
Department of Biology University of Fribourg Chemin du Musée 10 Room 1.302 CH-1700 Fribourg Switzerland (1)
Department of Biology, University of Fribourg Chemin du Musée 10, 1700 Fribourg, Switzerland T +41 26 300 8631 (1)
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Department of Translational Medicine – Hand Surgery, Lund University, Malmö, Sweden (1)
Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA, Hale Family Pancreatic Cancer Research Center, Dana-Farber Cancer Institute, Boston, MA 02215, USA (1)
Dr. rer. nat. Andreas Roos Project Leader "Tissue Proteomics" Leibniz-Institut für Analytische Wissenschaften ISAS e.V. (1)
Helmholtz-Centre for Environmental Research - UFZ (1)
Institute of Ecology and Evolution, University of Bern, Baltzerstrasse 6, CH-3012 Bern, Switzerland (1)
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Key Laboratory of Neuroregeneration, Nantong University, Nantong, China. (1)
Michel Salzet, Univ. Lille, Inserm, U-1192 - Laboratoire Protéomique, Réponse Inflammatoire et Spectrométrie de Masse-PRISM, F-59000 Lille, France (1)
Physiology & Pharmacology, Cumming School of Medicine, University of calgary, Cagary (1)
School of Clinical Medicine, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China, 750004. Ningxia Human Stem Cell Institute, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China, 750004. (1)
The University of Guelph, Guelph, Ontario, Canada. The department of Biomedical Sciences at the Ontario Veterinary College. (1)
Univ. Lille, Inserm, U-1192 - Laboratoire Protéomique, Réponse Inflammatoire et Spectrométrie de Masse-PRISM, F-59000 Lille, France (1)
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Quantitative Mass Spectrometry Analysis of the Injured Proximal and Distal Human Digital Nerve Ends

Proteomic analysis of injured human peripheral nerves, particularly focusing on events occurring in the proximal and distal nerve ends, remains relatively underexplored. This study aimed to investigate the molecular patterns underlying a digital nerve injury, concentrating on differences in protein ...

ORGANISM(S): Homo sapiens (Human)

2024-07-19 | PXD051266 | Pride

Timecourse expression data from sciatic nerve distal stump of C57BL/6 and C57BL/6 OlaHsd-Wlds mice.

Wallerian degeneration (WD) involves the fragmentation of axonal segments disconnected from their cell bodies, segmentation of the myelin sheath, and removal of debris by Schwann cells and immune cells. The removal and downregulation of myelin-associated inhibitors of axonal regeneration and synthes...

ORGANISM(S): Mus musculus

2011-06-01 | E-GEOD-22291 | biostudies-arrayexpress

Rat motor and sensory nerve LC-MSMS

Peripheral nerve repair and functional recovery depend on the rate of nerve regeneration and the quality of target reinnervation. It is important to fully understand the cellular and molecular basis underlying the specificity of peripheral nerve regeneration, which means the achieving of respective ...

ORGANISM(S): Rattus norvegicus (Rat)

2020-12-10 | PXD022097 | Pride

Lc-msms Sensory nerve Rat Motor nerve Peripheral nerve injury

Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun

After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during the chronic denervation that results from slow axon growth. This impairs axonal regeneration and ca...

ORGANISM(S): Mus musculus

2020-10-14 | E-MTAB-9640 | biostudies-arrayexpress

Differential gene expression in Danio rerio during optic nerve regeneration

To gain a better understanding of the factors necessary for successful CNS regeneration, a temporal analysis of the changes in gene expression in the eye caused by optic nerve injury was conducted. Dual color oligonucleotide microarrays were used to compare total RNA harvested from the eyes of sham...

ORGANISM(S): Danio rerio

2010-05-16 | E-GEOD-17854 | biostudies-arrayexpress

Nerve regeneration within a chitosan conduit after immediate and delayed nerve repair

PRJNA1244337 | ENA

Comparative proteomics analysis of growth-primed adult dorsal root ganglia reveals key molecular mediators for peripheral nerve regeneration

Peripheral nerve injuries due to physical insults or chronic diseases are quite common, yet no pharmacological therapies are available for the effective repair of injured nerves. The slow growth rate of adult nerves and insufficient access to growth factors pose major hurdles in timely reinnervating...

ORGANISM(S): Rattus norvegicus (Rat)

2023-01-06 | PXD031927 | Pride

Spinal root Rat Comparative proteomics Sciatic nerve Drgs Sensory neuron of dorsal root ganglion Nerve regeneration

Delay Modulates the Immune Response to Nerve Repair

PRJNA897851 | ENA

c-JUN REPROGRAMS SCHWANN CELLS OF INJURED NERVES TO GENERATE A REPAIR CELL ESSENTIAL FOR REGENERATION

The striking PNS regenerative response to injury rests on the plasticity of adult Schwann cells and their ability to transit between differentiation states, a highly unusual feature in mammals. Using mice with inactivation of Schwann cell c-Jun, we show that the injury response involves c-Jun depen...

ORGANISM(S): Mus musculus

2012-06-13 | E-GEOD-38693 | biostudies-arrayexpress

RNA-seq of mouse sciatic peripheral nerve of injured mouse with implant: control (untreated) vs local delivery of MCC950 (NLRP3inh) vs standard FBR treatment dexamethasone (Dex). .

RNA-seq comparing expression profile of peripheral nerve damage and microchannel device implantation repair model: control vs local delivery of MCC950 (NLRP3inh) vs standard FBR treatment dexamethasone (Dex).

ORGANISM(S): Mus musculus

2022-04-30 | E-MTAB-10293 | biostudies-arrayexpress

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