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Peripheral nerve injuries due to physical insults or chronic diseases are quite common, yet no pharmacological therapies are available for the effective repair of injured nerves. The slow growth rate of adult nerves and insufficient access to growth factors pose major hurdles in timely reinnervating...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-01-06 | PXD031927 | Pride
Expression from L4/5 DRGs after oral administration of LBP
Gene expression of injured DRGs from WT and Fmn2-/- mice
Axonal regeneration is enhanced by prior conditioning peripheral nerve lesions. Here we show that Xenopus dorsal root ganglia (DRGs) with attached peripheral nerves (PN-DRGs) can be conditioned in vitro, thereafter showing enhanced axonal growth in response to neurotrophins, similar to preparations...
ORGANISM(S): Xenopus laevis 
Lumbar 5 (L5) nerve compression affects adjacent DRGs and distal nerve
To compare the microRNAs (miRNAs) expression profile in the innervated soleus muscle and L4-L6 DRG neuronsafter sciatic nerve entrapment with a non-constrictive silastic tube, subsequent surgical decompression, and denervation injury. The experimental soleus muscles and dorsal root ganglions (DRGs) ...
ORGANISM(S): Rattus norvegicus 
Current study aimed to identify the gene expression change that are unique in injured Fmn2-/- DRGs compared with WT mice.
ORGANISM(S): Mus musculus 
2023-12-31 | GSE243896 | GEO
Single cell RNA sequencing analysis of mouse dorsal root ganglions (DRGs) with and without spared nerve injury.
Transcriptional profiling of L4-L6 DRGs in Twik-1 knockout mice following chronic constriction injury
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