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MetabolomicsIntergenerational Association of Gut Microbiota and Metabolism with Perinatal Folate Metabolism and Neural Tube Defects (Feces metabolomics)

Maternal folic acid intake is crucial for the development of the offspring's nervous system, and folic acid metabolism disorders during pregnancy lead to neural tube defects (NTDs) in the fetus. Folic acid and vitamins biosynthesis is a major biochemical feature of gut microbiota. The complex and...

2022-12-05 | MTBLS4893 | MetaboLights
TranscriptomicsAnalysis of conditional loss of Geminin in neural tube and paraxial tissues at E10.5 by laser capture microdissection
To better understand the role of Geminin during germ layer specification, we bred floxed Geminin mice to Mox2-Cre mice. Mutants (fl/fl; cre/o) had spinal neural tube defects with complete penetrance. We obtained neural tube and paraxial tissue by laser capture microdissection and analyzed total RNA...
ORGANISM(S): Mus musculus 
2014-09-30 | E-GEOD-42052 | biostudies-arrayexpress
GenomicsProgram specificity for Ptf1a in PancreasM-BM- versusM-BM- Neural Tube DevelopmentM-BM- correlates with distinctM-BM- collaborating cofactors and chromatin accessibility
Ptf1a is a lineage-specific basic-helix-loop-helix transcription factor critical in the development of both the pancreas and nervous system. How one transcription factor controls diverse programs of gene expression is a fundamental question in developmental biology. To uncover molecular strategies f...
ORGANISM(S): Mus musculus 
2013-08-15 | E-GEOD-47459 | biostudies-arrayexpress
TranscriptomicsDevelopment of a Neural Teratogenicity Test Based on Human Embryonic Stem Cells- Response to Retinoic Acid Exposure
The aim of this study was the development of an alternative testing method based on human embryonic stem cells for prenatal developmental toxicity with particular emphasis on early neural development. To this purpose, we designed an in vitro protocol based on the generation of neural rosettes, repre...
ORGANISM(S): Homo sapiens 
2012-03-13 | E-MEXP-3577 | biostudies-arrayexpress
TranscriptomicsDEVELOPMENTAL MicroRNA EXPRESSION PROFILING OF MURINE NEURAL TUBE
BACKGROUND: Development of the neural tube is a highly orchestrated process relying on precise, spatio-temporal expression of numerous genes as well as hierarchies of signal transduction and gene regulatory networks. Disruption of expression of a number of genes participating in these networks is be...
ORGANISM(S): Rattus norvegicus 
2010-12-01 | E-GEOD-20879 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling by array of chick embryonic tissues: gastrulation, neural tube/notochord and limb development.
Microarray analysis of chick embryo tissues: Hamburger Hamilton (HH) stage 3+/4 and HH6 Hensen’s node, HH 3+/4 posterior primitive streak, notochord with ventral neural tube at HH10-11, dorsal neural tube at HH10-11 and anterior and posterior thirds of the wing bud at stages HH20-21 and HH24.
ORGANISM(S): Gallus gallus 
2016-08-23 | E-MTAB-4048 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in the developing neural tube
At an incidence of approximately 1/1000 births, neural tube defects (NTDs) comprise one of the most common and devastating congenital disorders. In an attempt to enhance and expand our understanding of neural tube closure, we undertook a high-throughput gene expression analysis of the neural tube as...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-39442 | biostudies-arrayexpress
TranscriptomicsExpression data from mouse embryo during neural tube closure
This data series was used for two separate studies. The initial study was aimed to idenify expression changes brought about by the Cecr2Gt45Bic mutation during neural closure. The study included two different strains, BALB/cCrl in which Cecr2GT45Bic shows a neural tube defect phenotype and FVB/N in ...
ORGANISM(S): Mus musculus 
2012-02-27 | E-GEOD-30957 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse murine dorsal neural tube bisected along the midline with one half from each embryo used for control and the other half treated with 10-6M RA dissolved in ethanol for 6, 12, 24 or 48 h
This series represents murine dorsal neural tube bisected along the midline with one half from each embryo used for control and the other half treated with 10-6M RA dissolved in ethanol for 6, 12, 24 or 48 h. For 6 h exposures, the explants were cultured overnight on fibronectin coated 35mm dishes (...
ORGANISM(S): Mus musculus 
2007-10-11 | E-GEOD-1588 | biostudies-arrayexpress
TranscriptomicsConcerted involvement of Cdx/Hox genes and Wnt signalling in morphogenesis of the caudal neural tube and cloacal derivatives from the posterior growth zone.
Decrease in Cdx dosage in an allelic series of mouse Cdx mutants leads to progressively more severe posterior vertebral defects. These defects are corrected by posterior gain of function of the Wnt effector Lef1. Precocious expression of Hox paralogous 13 genes also induces vertebral axis truncat...
ORGANISM(S): Mus musculus 
2011-12-01 | E-GEOD-30113 | biostudies-arrayexpress
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