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GenomicsCanonical and non-canonical PRC1 differentially contribute to the regulation of neural stem cell fate
Canonical and non-canonical PRC1 differentially contribute to the regulation of neural stem cell fate
PRJNA1147753 | ENA
UnknownCanonical and non-canonical PRC1 differentially contribute to regulation of neural stem cell fate.
Not available
S-EPMC11814486 | biostudies-literature
UnknownUncoupled evolution of the Polycomb system and deep origin of non-canonical PRC1.
Not available
S-EPMC10638273 | biostudies-literature
TranscriptomicsCanonical and non-canonical PRC1 differentially contribute to the regulation of neural stem cell fate
Neocortex development is characterized by sequential phases of neural progenitor cell (NPC) expansion, neurogenesis and gliogenesis. Polycomb-mediated epigenetic mechanisms are known to play important roles in regulating the lineage potential of NPCs during development. The composition of Polycomb R...
ORGANISM(S): Mus musculus 
2025-01-30 | GSE274747 | GEO
ProteomicsDOT1L-mediated repression of non-canonical PRC1 target genes maintains the pro-proliferative identity of Diffuse Large B Cell Lymphoma
To determine whether the inhibition of DOT1L (EPZ-5675) affects the enrichment of components within specific non-canonical PRC1 (ncPRC1) complexes, we performed rapid immunoprecipitation mass spectrometry of endogenous protein (RIME) of BCOR (ncPRC1.1) and PCGF6 (ncPRC1.6) for human GCB-DLBCL cell l...
ORGANISM(S): Homo sapiens (Human) 
2026-10-19 | PXD061504 | Pride
Diffuse large b cell lymphoma   dot1l   bcor   pcgf6   non-canonical prc1   immunoprecipitation 
ProteomicsUnbalanced chromatin binding of PRC1 complexes drives neurodevelopmental disorders
Heterozygous de novo missense mutations in genes encoding Polycomb-group (PcG) proteins can cause diverse neurodevelopmental disorders (NDDs), but the underlying mechanisms are not yet understood. Here, we identified novel mutations in the two E3-ligases of the Polycomb Repressive complex 1 (PRC1), ...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-06 | PXD059191 | Pride
Neurodevelopment Rnf2 Prc1 Polycomb Mutations 
GenomicsA Non-canonical BCOR-PRC1.1 Complex Represses Differentiation Programs in Human ESCs
A Non-canonical BCOR-PRC1.1 Complex Represses Differentiation Programs in Human ESCs
PRJNA413520 | ENA
UnknownIdentification of germ cell-specific Mga variant mRNA that promotes meiosis via impediment of a non-canonical PRC1.
Not available
S-EPMC8102552 | biostudies-literature
GenomicsFbxl10 regulates PRC1 recruitment to CpG islands and H2A ubiquitination
Polycomb repressive complex 1 (PRC1) catalyzes H2A monoubiquitination (uH2A) and regulates pluripotency in embryonic stem cells (ESCs). However the mechanisms controlling PRC1 recruitment and activity are largely unknown. Here we show that Fbxl10 interacts with Ring1B and Nspc1, forming a non-canoni...
ORGANISM(S): Mus musculus 
2012-12-31 | E-GEOD-37930 | biostudies-arrayexpress
GenomicsNon-canonical PRC1.1 targets active genes independent of H3K27me3 and is essential for leukemogenesis
Polycomb proteins are classical regulators of stem cell self-renewal and cell lineage commitment and are frequently deregulated in cancer. Here we find that the non-canonical PRC1.1 complex, as identified by mass spectrometry-based proteomics, is critically important for human leukemic stem cells. D...
ORGANISM(S): Homo sapiens 
2015-11-24 | E-GEOD-54580 | biostudies-arrayexpress
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