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GenomicsPromoter Decommissioning by the NuRD Chromatin Remodeling Complex Triggers Synaptic Connectivity in the Mammalian Brain
Precise control of gene expression plays fundamental roles in brain development, but the roles of chromatin regulators in neuronal connectivity have remained poorly understood. Here, we find that depletion of the nucleosome remodeling and deacetylation (NuRD) complex in the cerebellar cortex by in v...
ORGANISM(S): Mus musculus 
2014-08-18 | E-GEOD-57758 | biostudies-arrayexpress
GenomicsZFHX4 and CHD4 ChIP sequencing in glioblastoma tumor initiating cells
Glioblastomas (GBM) harbor subpopulations of therapy-resistant tumor initiating cells (TICs) that are self-renewing and multipotent. To understand the regulation of the TIC state, we performed an image-based screen for genes regulating GBM TIC maintenance and identified ZFHX4, a 397-kDa transcriptio...
ORGANISM(S): Homo sapiens 
2014-01-16 | E-GEOD-52419 | biostudies-arrayexpress
GenomicsNuRD-mediated gene repression in mouse embryonic stem cells
To obtain a global view of NuRD-mediated transcriptional regulation, gene expression profiles of wild-type and Mbd3-null ES cells were compared by microarray analysis. In the absence of Mbd3, which encodes a core structural component of NuRD, the complex does not form and embryonic development stall...
ORGANISM(S): Mus musculus 
2012-03-13 | E-MTAB-888 | biostudies-arrayexpress
TranscriptomicsNuRD-mediated gene repression in mouse embryonic stem cells
To obtain a global view of NuRD-mediated transcriptional regulation, gene expression profiles of wild-type and Mbd3-null ES cells were compared by microarray analysis. In the absence of Mbd3, which encodes a core structural component of NuRD, the complex does not form and embryonic development stall...
ORGANISM(S): Mus musculus 
2012-03-13 | E-MTAB-889 | biostudies-arrayexpress
ProteomicsUnique Protein Interaction Networks Define The Chromatin Remodeling Module of The NuRD Complex
The combination of four proteins and their paralogues including MBD2/3, GATAD2A/B, CDK2AP1, and CHD3/4/5, which we refer to as the MGCC module, form the chromatin remodeling module of the Nucleosome Remodeling and Deacetylase (NuRD) complex. To date, mechanisms by which the MGCC module acquires para...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD025263 | Pride
Chahp complex Mass spectrometry Chromatin remodeling Ncor complex Protein-protein interactions Nurd complex Aggregation protein region 
ProteomicsThe NuRD complex is required for Thpok-mediated CD4+ T cell development
This data represent characterization of the interactome of murine Thpok. A version of Thpok (Thpok-Bio) subject to biotinylation in vivo by the BirA biotin ligase was used; to assess Thpok interactions in primary cells, Thpok-Bio was retrovirally expressed in in vitro activated CD4+ T cells from Thp...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
MSV000088126 | MassIVE
ProteomicsComprehensive cross-linking mass spectrometry reveals molecular insights into the between peripheral and core NuRD complex subunits
Affinity purifications of different subunits of the NuRD complex, followed by cross-linking mass spectrometry (xIP-MS) to identify interaction domains. Six subunits and an interactor of NuRD were cross-inked with either BS3 or ADH/DMTMM and digested with either trypsin or chymotrypsin, to generate a...
ORGANISM(S): Homo sapiens (Human) 
2020-12-07 | PXD017244 | Pride
Mbd Chd Xip-ms Cross-linking Nurd 
UnknownSystemic identification and characterization of the conserved core NuRD complex in planarian.
Not available
S-EPMC12518275 | biostudies-literature
UnknownThe structure of the core NuRD repression complex provides insights into its interaction with chromatin.
Not available
S-EPMC4841774 | biostudies-literature
GenomicsChIP-seq of NuRD components and pluripotency factors in wild-type, Mbd3 and Sall4/1 mutant embryonic stem cells
Members of the Nucleosome Remodeling and Deacetylase (NuRD) complex Mbd3 and Mi2beta (Chd4) along with pluripotency regulators Nanog, Oct4, Klf4 and Esrrb were profiled for chromatin association by ChIP-seq in mouse embryonic stem cells mutant for Mbd3, Sall4 and/or the related Sall1 pluripotency-as...
ORGANISM(S): Mus musculus 
2016-08-09 | E-MTAB-4565 | biostudies-arrayexpress
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