oocyte meiotic maturation

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Lab affiliation

Reproductive Medicine Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, No.218 Jixi Road, Hefei 230022, China (2)
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Department of Meiosis, Max Planck Institute for Multidisciplinary Sciences; Göttingen, Germany (1)
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Deputy head of department at Department of Translational Medicine. Lund University. Principal investigator at CEBMMS PI. Professor at Clinical Chemistry, Malmö Professor at Clinical Protein Science and Imaging Professor at Department of Clinical Sciences, Lund (1)
State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing 211166, China (1)
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Department of Biology, AG Stengel, University of Konstanz, Germany (1)
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Department of Comparative Biosciences, University of Illinois at Urbana-Champaign (1)
Center for Stem Cell Biology and Regenerative Medicine, MOE Key Laboratory of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing, China (1)
State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing 211166, China (1)
Department of Biomolecular Medicine, Ghent University, Ghent, Belgium VIB Center for Medical Biotechnology, VIB, Ghent, Belgium (1)
Department of Biology, Cellular Proteostasis and Mass Sepectrometry, University of Konstanz (1)
Nanjing Med Univ, State Key Lab Reprod Med, Dept Histol & Embryol, 140 Hanzhong Rd, Nanjing 210029, Jiangsu, Peoples R China. (1)
Department of Zoology and Anthropology, Faculty of Natural Sciences and Informatics, Constantine the Philosopher University in Nitra (1)
Peking University Third Hospital No. 49 North Garden Road, Haidian District Beijing 100191, China (1)
Plate-forme d'Analyse Intégrative des Biomolécules et de Phénomique des Animaux d'Intérêt Bio-agronomique (PAIB2) UMR INRA 85 - CNRS 7247 - UFR - IFCE Physiologie de la Reproduction et des Comportements INRA Centre Val de Loire (Tours) 37380 NOUZILLY (1)
Department of Genetics, Cell Biology, and Development, University of Minnesota, 4-208 MCB, 420 Washington Avenue SE, Minneapolis, MN 55455. Tel: 612-624-3955; FAX: 612-626-6140. (1)

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Uridine restores oocyte quality and mitigates female reproductive aging by inhibition of ferroptosis in mice

Advanced maternal age is a key factor in female infertility, primarily due to declines in ovarian reserve and oocyte quality. However, the metabolic mechanisms underlying reproductive aging are still poorly understood. Here, we show that uridine levels in the plasma and ovaries of aged mice are s...

2026-03-03 | MTBLS13957 | MetaboLights

Transcription profiling of immature germinal vesicle stage oocytes with mature metaphase II oocytes to identify and characterize the changed and stable transcripts during mouse oocyte maturation.

There is massive destruction of transcripts during maturation of mouse oocytes. The objective of this project was to identify and characterize the transcripts that are degraded versus those that are stable during the transcriptionally silent germinal vesicle (GV)-stage to metaphase II (MII)-stage t...

ORGANISM(S): Mus musculus

2007-11-13 | E-GEOD-5668 | biostudies-arrayexpress

Proteomic profiling reveals the molecular control of oocyte maturation

Meiotic maturation is an intricate and precisely regulated process orchestrated 32 by various pathways and numerous proteins. However, little is known about the 33 proteome landscape during oocytes maturation. Here, we obtained the temporal 34 proteomic profiles of mouse oocytes during in vivo ma...

ORGANISM(S): Mus Musculus

2022-05-26 | PXD034150 |

LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance

Fully grown oocytes remain transcriptionally quiescent, yet many maternal mRNAs are synthesized and retained in growing oocytes. We now know that maternal mRNAs are stored in a structure called the mitochondria associated ribonucleoprotein domain (MARDO). But the components and functions of MARDO re...

ORGANISM(S): Mus musculus (Mouse)

2023-10-17 | PXD042761 | Pride

RNA-sequencing of pig oocyte throughout meiotic maturation

PRJNA993490 | ENA

Gene Expression Profiles in Immature and In vitro matured bovine Oocytes

In cattle, almost all fully grown vesicle stage oocytes (GV) have the ability to resume meisos, develop to Metaphase II stage (MII), support fertilization and progress through the early embryonic cycles in vitro. Yet without intensive selection, the majority fail to develop to the blastocyst stage. ...

ORGANISM(S): Bos taurus

2011-04-25 | E-GEOD-23449 | biostudies-arrayexpress

Effects of Dcp1a and Dcp2 knockdown during mouse oocyte maturation

Oocyte maturation is accompanied by a transition from mRNA stability to instability. We investigated the role of DCP1A and DCP2, proteins responsible for mRNA decapping, in mRNA destabilization during mouse oocyte maturation. siRNA-mediated knockdown of both Dcp1a and Dcp2 transcripts prior to ini...

ORGANISM(S): Mus musculus

2013-02-06 | E-GEOD-27049 | biostudies-arrayexpress

Polysome-bound mRNA during oocyte maturation

Oocyte maturation, fertilization, and early embryonic development occur in the absence of gene transcription. Therefore, it is critical to understand at a global level the post-transcriptional events that are driving these transitions. Here, we have used a systems approach by combining polysome mRNA...

ORGANISM(S): Mus musculus

2012-01-14 | E-GEOD-35106 | biostudies-arrayexpress

Transcriptional profile associated with human oocyte meiotic maturation

PRJNA639579 | ENA

OMA-1, LIN-41 IPMS - LIN-41 and OMA Ribonucleoprotein Complexes Mediate a Translational Repression-to-Activation Switch Controlling Oocyte Meiotic Maturation and the Oocyte-to-Embryo Transition in Caenorhabditis elegans

An extended meiotic prophase is a hallmark of oogenesis. Hormonal signaling activates the CDK1/cyclin B kinase to promote oocyte meiotic maturation, which involves nuclear and cytoplasmic events. Nuclear maturation encompasses nuclear envelope breakdown, meiotic spindle assembly, and chromosome segr...

ORGANISM(S): Caenorhabditis elegans

2017-06-16 | PXD006726 | Pride

Oma-1 lin-41 ribonucleoprotein complex

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