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MetabolomicsMetabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS
As metabolic rewiring is crucial for cancer cell proliferation, metabolic phenotyping of patient-derived organoids is desirable to identify drug-induced changes and trace metabolic vulnerabilities of tumor subtypes. We established a novel protocol for metabolomic and lipidomic profiling of colorecta...
2021-10-12 | MTBLS2130 | MetaboLights
MetabolomicsEVOLUTION OF THE LIPIDOME UNCOVERS EARLY CHANGES IN ADRENOLEUKODYSTROPHY HUMAN CORTICAL AND SPINAL ORGANOIDS

Lipids are critical for the structure, signaling, and metabolism of the central nervous system (CNS), yet their roles during human brain development remain underexplored due to limited tissue availability. X-linked adrenoleukodystrophy (ALD), a peroxisomal disorder caused by ABCD1 mutat...

2025-11-17 | MTBLS12973 | MetaboLights
MetabolomicsMass spectrometry imaging as an emerging tool for studying metabolism in human brain organoids

Human brain organoids are emerging models to study human brain development and pathology as they recapitulate the development and characteristics of major neural cell types, and enable manipulation through an in vitro system. Over the past decade, with the advent of spatial technologies,...

2023-05-23 | MTBLS7565 | MetaboLights
MetabolomicsMetabolic Substrate Availability Regulates Nephron Lineage Expansion in Human Kidney Organoids
Human induced pluripotent stem cell-derived kidney organoids are widely used to model nephrogenesis, but variability in basal media composition remains an underappreciated source of developmental heterogeneity. Because nephrogenesis involves rapid proliferation and differentiation, we hypothesized t...
2026-10-18 | MTBLS16048 | MetaboLights
MetabolomicsIntegrated Multi-omics Analysis of Human Biliary Organoids Reveals Dysregulated Metabolic and Fibro-Inflammatory Programs in Biliary Atresia
Human intrahepatic biliary organoids were established from liver tissues of children with BA (n = 11), choledochal cysts (CC, n = 5), and histologically normal controls (NC, n = 5). We performed comprehensive multi-omics profiling, including transcriptomics, proteomics, phosphoproteomics, and untarg...
2026-09-02 | MTBLS15528 | MetaboLights
MetabolomicsIsotope Tracing Analysis in Intestinal Organoids with fructose
Not available
ORGANISM(S): Mus musculus 
ST001622 | MetabolomicsWorkbench
MetabolomicsUntargeted metabolomics of intestinal organoids treated with fructose
Not available
ORGANISM(S): Mus musculus 
ST001621 | MetabolomicsWorkbench
MetabolomicsEffect of PARK7 gene KO on midbrain organoids
Not available
ORGANISM(S): Homo sapiens 
ST002327 | MetabolomicsWorkbench
MetabolomicsLipid Profiling of Mouse Intestinal Organoids for studying APC Mutations
Not available
ORGANISM(S): Mus musculus 
ST001707 | MetabolomicsWorkbench
MetabolomicsGenetically defined human GBM organoids reveal principles of GBM development and actionable targets
Not available
ORGANISM(S): Homo sapiens 
ST002284 | MetabolomicsWorkbench
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