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ProteomicsOxadiazolone derivatives against M. tuberculosis
Oxadiazolone (OX) derivatives have been investigated for their antimycobacterial activity against three pathogenic slow-growing mycobacteria: Mycobacterium marinum, Mycobacterium bovis BCG and the avirulent Mycobacterium tuberculosis (M. tb) mc26230. The encouraging MIC values obtained prompted us t...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2018-09-25 | PXD010255 | Pride
Tuberculosis Lipolytic enzyme inhibitors Activity-based probe (abp) Oxadiazolone 
UnknownIdentification of selective covalent inhibitors of platelet activating factor acetylhydrolase 1B2 from the screening of an oxadiazolone-capped peptoid-azapeptoid hybrid library.
Not available
S-EPMC4972644 | biostudies-literature
UnknownDissecting the antibacterial activity of oxadiazolone-core derivatives against Mycobacterium abscessus.
Not available
S-EPMC7500638 | biostudies-literature
ProteomicsDissecting the antibacterial activity of Oxadiazolone-core derivatives against Mycobacterium abscessus
Mycobacterium abscessus is nowadays under the spotlight of the scientific community. This pathogenic mycobacteria is indeed responsible for a wide spectrum of infections involving mostly pulmonary infections in patients with cystic fibrosis. M. abscessus is intrinsically resistant to a broad range o...
ORGANISM(S): Mycobacterium abscessus 
2020-08-14 | PXD015680 | Pride
Drug susceptibility  intracellular activity  activity based-protein profiling  proteomic analysis 
UnknownDevelopment of Oxadiazolone Activity-Based Probes Targeting FphE for Specific Detection of <i>S. aureus</i> Infections.
Not available
S-EPMC10760020 | biostudies-literature
ProteomicsOxadiazolone derivatives block Staphylococcus aureus growth and biofilm formation by covalently binding to strategic (Ser/Cys)-based enzymes
Staphylococcus aureus is a Gram-positive opportunistic pathogen and a top-priority bacterium in the fight against antimicrobial resistance. Its high propensity to mutate, develop resistance, and become more virulent, as well as its ability to form biofilms, results in difficult-to-treat infections a...
ORGANISM(S): Staphylococcus aureus 
2026-04-01 | PXD073012 | Pride
Lc-msms Dia Gram-positive bacteria  antibiotic resistance  antibiofilm activity  activity-based protein profiling  fabh 
UnknownDesign, synthesis, and analysis of antagonists of GPR55: Piperidine-substituted 1,3,4-oxadiazol-2-ones.
Not available
S-EPMC4836065 | biostudies-literature
UnknownPhenolate-Induced N-O Bond Formation versus TiemannType Rearrangement for the Synthesis of 3-Aminobenzisoxazoles and 2-Aminobenzoxazoles.
Not available
S-EPMC9789021 | biostudies-literature
ProteomicsMapping of mycobacterial lipolytic enzymes involved in triacylglycerol accumulation as intrabacterial lipid inclusions using multi-target inhibitor-like affinity-based probes
Mycobacteria are known for their unique and complex cell wall architecture, characterized by distinct lipid-rich outer layers, making lipid metabolism a central point of their physiological processes. One crucial aspect of all mycobacteria is their ability to metabolize host lipids and to accumulate...
ORGANISM(S): Mycobacterium abscessus 
2025-05-12 | PXD048770 | Pride
Mycobacterium Lc_msms Activity-based protein profiling  multitarget inhibitor-like affinity-based probes  lipid metabolism  cyclipostins & cyclophostin  oxadiazolone 
ProteomicsThe polyamino-isoprenyl enhancer NV716 potentializes the antibacterial activity of two families of multitarget inhibitors against the ESKAPEE bacterium Enterobacter cloacae, Part1bis (Enterobacter cloacae)
The spread of antimicrobial resistance (AMR), coupled with the decline in antibiotic development, has become a major public health concern. Recent studies estimate that around 700,000 people die each year from infections caused by multidrug-resistant (MDR) bacteria. This led the WHO to publish the E...
ORGANISM(S): Enterobacter cloacae 
2025-02-27 | PXD053955 | Pride
Gram-negative bacteria  antibiotic resistance  drug enhancers  oxadiazolone derivatives  cyclipostins & cyclophostin analogs  activity based-protein profiling 
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