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ProteomicsPDI-catalyzed oxidative protein folding mediates senescence by induction of ER-derived oxidative stress
Protein homeostasis is linked with aging and aging associated diseases. Oxidative protein folding occurs in the endoplasmic reticulum (ER) and produces H2O2 as a byproduct. The role of oxidative protein folding in human stem cells aging remains unknown. Here, we succeed to knockout protein disulfide...
ORGANISM(S): Homo sapiens (Human) 
2023-06-12 | PXD037244 | Pride
Human mesenchymal stem cells (hmscs)  hydrogen peroxide (h2o2)  oxidative 29 protein folding  protein disulfide isomerase (pdi)  senescence 
UnknownPlasticity in the Oxidative Folding Pathway of the High Affinity Nerita Versicolor Carboxypeptidase Inhibitor (NvCI).
Not available
S-EPMC5511257 | biostudies-literature
UnknownRiboflavin deficiency impairs oxidative folding and secretion of apolipoprotein B-100 in HepG2 cells, triggering stress response systems.
Not available
S-EPMC1201499 | biostudies-literature
UnknownCrystal structure of the ectodomain of Methuselah, a Drosophila G protein-coupled receptor associated with extended lifespan.
Not available
S-EPMC31123 | biostudies-literature
UnknownStructural and functional specialization of Bordetella pertussis DsbA for pertussis toxin folding.
Not available
S-EPMC12724015 | biostudies-literature
TranscriptomicsStage-specific expression of TNFM-NM-1 regulates bad/bid-mediated apoptosis and RIP1/ROS-mediated secondary necrosis in Birnavirus-infected fish cells
Infectious pancreatic necrosis virus (IPNV) is a fish-derived pathogen and possess a bi-segmented, double-stranded RNA genome. By using zebrafish 14K oligo-microarray and quantitative RT-PCR, we identified differential expression of a defined subset of genes involved in apoptosis and immunity at 6-,...
ORGANISM(S): Danio rerio 
2011-02-01 | E-GEOD-21077 | biostudies-arrayexpress
TranscriptomicsIdentification of Yeast Genes that Confer Resistance to Chitosan Oligosaccharide (COS) Using Chemogenomics
Abstract: Chemogenomic fitness assays were combined with a transcriptome analysis to understand both the mode of action and the mechanisms of resistance to Chitosan oligosaccharides (COS). COS are deacetylated chitin compounds, with antimicrobial properties, that are presumed to act by disrupting t...
ORGANISM(S): Saccharomyces cerevisiae 
2012-12-22 | E-GEOD-32888 | biostudies-arrayexpress
ProteomicsALR Couples IMS Redox and Heme Biosynthesis Beyond the Disulfide Relay
Denaturing pulldown of ALR-HA from HEK293 cells to identify the covalent interaction partners of ALR. One half of the samples were treated with DTT during the Co-IP protocol to verify that the interactions are disulfide related. Accordingly, no Mock-cell lines was used. One half of the samples from ...
ORGANISM(S): Homo sapiens (Human) 
2026-04-16 | PXD075266 | Pride
Heme biosynthesis Oxidative protein folding Mitochondria 
UnknownTranscriptomic responses to high water temperature in two species of Pacific salmon.
Not available
S-EPMC3927889 | biostudies-literature
UnknownIn silico Study of Iron, Zinc and Copper Binding Proteins of Pseudomonas syringae pv. lapsa: Emphasis on Secreted Metalloproteins.
Not available
S-EPMC6110883 | biostudies-literature
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