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ProteomicsProteome analysis of affinity-purified protein co-precipitates
HBO1-MLL interaction promotes AF4/ENL/P-TEFb-mediated leukemogenesis
ORGANISM(S): Homo Sapiens (human) 
2021-08-31 | PXD027400 | JPOST Repository
GenomicsP-TEFb function in ncRNA transcription
P-TEFb function in ncRNA transcription
PRJNA483416 | ENA
TranscriptomicsRBM7 activates P-TEFb for a pro-survival transcriptional response to DNA damage
DNA damage response (DDR) involves dramatic transcriptional alterations, the mechanisms of which remain obscure. Here we show that following DNA damage, the RNA-binding motif protein 7 (RBM7) stimulates RNA polymerase II (Pol II) elongation and increases cell viability by activating the positive tra...
ORGANISM(S): Homo sapiens 
2018-06-01 | E-MTAB-6475 | biostudies-arrayexpress
GenomicsGenome-wide map of RNA polymerase II, NELF, and DSIF in HeLa cells
Most metazoan promoters have RNA polymerase II (Pol II) paused slightly downstream of the transcription start site by NELF and DSIF. This pausing keeps these promoters available for rapid induction by P-TEFb, whose activity causes NELF to dissociate and Pol II and DSIF to elongate on the gene. ChIP-...
ORGANISM(S): Homo sapiens 
2014-02-01 | E-GEOD-53008 | biostudies-arrayexpress
GenomicsThe 7SK/P-TEFb snRNP controls ultraviolet radiation-induced transcriptional reprogramming
The 7SK/P-TEFb snRNP controls ultraviolet radiation-induced transcriptional reprogramming
PRJNA612855 | ENA
ProteomicsMethionine Restriction Alleviates Kidney Fibrosis through Epigenetic Repression of the TGF-β-Smad3-Hoxc8/P-TEFb axis
Low-protein diets can mitigate renal fibrosis, yet the critical amino acid responsible for this benefit and its underlying mechanism remain unclear. By screening 15 amino acid–restricted diets in a unilateral ureteral obstruction (UUO) model, we identify methionine restriction (MetR) as the most eff...
ORGANISM(S): Homo sapiens (Human) 
2025-12-04 | PXD071531 | Pride
Kidney fibrosis  methionine restriction  hoxc8  p-tefb 
GenomicsRBM7 activates P-TEFb for a pro-survival transcriptional response to DNA damage
RBM7 activates P-TEFb for a pro-survival transcriptional response to DNA damage
PRJEB24882 | ENA
GenomicsP-TEFb function in ncRNA transcription
Many ncRNAs serve as regulatory molecules in various physiological pathways. Distinct from protein-coding RNA expression, ncRNA expression is regulated solely by transcription and RNA processing/stability. Transcriptional regulation in ncRNA genes is thus important to be understood and is yet to be ...
ORGANISM(S): Homo sapiens 
2018-07-31 | GSE117848 | GEO
UnknownP-TEFb goes viral.
Not available
S-EPMC4863834 | biostudies-literature
TranscriptomicsTranscriptional Pause Release Is a Rate-Limiting Step for Somatic Cell Reprogramming (RNA-seq)
Reactivation of the pluripotency network during somatic cell reprogramming by exogenous transcription factors involves chromatin remodeling and the recruitment of RNA polymerase II (Pol II) to target loci. Here, we report that Pol II is engaged at pluripotency promoters in reprogramming but remains ...
ORGANISM(S): Mus musculus 
2014-10-07 | E-GEOD-59813 | biostudies-arrayexpress
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