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Human skeletal tissue contains an abundance of proteins some of which may be preserved over geological timescales. The profiling of proteins from ancient individuals — or palaeoproteomics —has begun to provide new information about the diseases suffered in past societies. We describe here the first ...
ORGANISM(S): Homo sapiens (Human) 
2019-11-20 | PXD008479 | Pride
Screening archaeological bone for palaeogenetic and palaeoproteomic studies
Spotted hyena (Crocuta crocuta) is the only extant species of the genus Crocuta, which once occupied a much wider range during the Pliocene and Pleistocene. However, its origin and evolutionary history is somewhat contentious due to discordances being found between morphological, nuclear, and mitoch...
ORGANISM(S): Crocuta 
2020-10-19 | PXD020530 | Pride
Contamination is a potential issue in palaeoproteomic studies of human evolution, as it may mask low-abundance endogenous proteins and introduce modern variation into the reconstructed ancient proteome. This contamination may stem from many sources, such as the burial environment, storage facilities...
ORGANISM(S): Homo 
2025-04-24 | PXD050370 | Pride
Palaeoproteomic analysis of skeletal elements is increasingly used to study topics such as human evolution. However, many of the skeletal elements that are analysed have been stored and handled over long time periods, and have therefore accumulated contaminating proteins, which may complicate analys...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) Equus caballus (Horse) 
2025-04-24 | PXD050393 | Pride
An archaeological bone fragment from Baishiya Karst Cave, China, was identified as stemming from a hominin through ZooMS (Zooarchaeology by Mass Spectrometry). Shotgun palaeoproteomic analyses were thereafter conducted on the specimen to refine the taxonomic identification and perform phylogenetic a...
ORGANISM(S): Homo 
2024-05-22 | PXD047932 | Pride
Hominin fossil and genetic evidence indicate that several hominin populations occupied East and Southeast Asia during the Middle and Late Pleistocene. Despite the existence of well-documented hominin fossil collections north of 25°N latitude and south of 7°S latitude, on Java, H. erectus fossils rem...
ORGANISM(S): Ailuropoda Tapirus sp. Homo Rhinoceros unclassified Elephas Proboscidea <placentals> 
2026-10-07 | PXD072522 | Pride
We use palaeoproteomic analysis to obtain the taxonomic identification of an exceptional bone tool from a Bronze Age site near Heiloo, the Netherlands. ZooMS, SPIN and a conventional MaxQuant database search were employed to narrow down the species the tool belonged to. Here, only the LC-MS/MS raw d...
ORGANISM(S): Eubalaena glacialis 
2024-04-20 | PXD051408 | Pride
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