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MetabolomicsPalmitic Acid-Triggerd B7H3 Palmitoylation Promotes Immune Escape

B7H3 (CD276), a key immune checkpoint molecule that is overexpressed in tumors, plays a central role in cancer progression, making it a highly promising and specific therapeutic target. Here, we discovered that the cellular metabolite palmitic acid contributes to the development of an immunosuppr...

2025-12-03 | MTBLS12300 | MetaboLights
MetabolomicsGestational palmitic acid suppresses embryonic GATA-binding protein 4 signaling and causes congenital heart disease
Dysregulated maternal fatty acid metabolism increases the risk of congenital heart disease (CHD) in offspring with an unknown mechanism, and the effect of folic acid fortification in preventing CHD is controversial. Using gas chromatography coupled to either a flame ionization detector or mass spect...
2023-03-24 | MTBLS6982 | MetaboLights
MetabolomicsHigh-fat diet increases circulating palmitic acid produced by gut Bacteroides thetaiotaomicron to promote thrombosis

Circulating palmitic acid (PA) is generally considered to be provided from diets and endogenous synthesis, and is adversely correlated with cardiovascular disease (CVD). It is unknown, however, if gut microbiota modulates circulating PA and potentiate CVD risk. Here we demonstrate that in CVD pat...

2025-06-20 | MTBLS12618 | MetaboLights
MetabolomicsPalmitic acid-mediated TLR4/NF-κB activation drives the pathogenicity of hypervirulent Bordetella pertussis MT28 lineage

Whooping cough resurged globally despite the widespread vaccination. A macrolide-resistant (MR) lineage carrying the high-virulence ptxP3 allele, ptxP3 MR-MT28 (MT28), has imposed a substantial burden on pertussis epidemics, while the underlying factors driving its prevalence remain unclear. Thus...

2025-06-21 | MTBLS12625 | MetaboLights
MetabolomicsReleased palmitic acid–mediated TLR4/NF-κB activation enhances the virulence of Bordetella pertussis MT28 lineage

Whooping cough resurged globally despite the widespread vaccination. A macrolide-resistant (MR) lineage carrying the high-virulence ptxP3 allele, ptxP3 MR-MT28 (MT28), has imposed a substantial burden on pertussis epidemics, while the underlying factors driving its prevalence remain unclear. Thus...

2025-12-21 | MTBLS13545 | MetaboLights
TranscriptomicsEffect of exogenous FABP4 (A-FABP/aP2) with and without palmitic acid on gene expression in RAW264.7 macrophages
Gene expression profile of FABP4 treatment in RAW264.7 macrophages was examined to show a ligand (palmitic acid)-dependent and a ligand-independent effect of FABP4. RAW264.7 macrophages were treated with and without 200 nM recombinant FABP4 in the absence and presence of 0.2 mM palmitic acid.
ORGANISM(S): Mus musculus 
2015-09-19 | E-GEOD-73173 | biostudies-arrayexpress
TranscriptomicsEicosapentaenoic acid improves metabolic switching in human myotubes
Metabolically healthy skeletal muscle is characterized by the ability to switch easily between glucose and fat oxidation, whereas loss of this ability seems to be related to insulin resistance. The aim of this study was to investigate whether different fatty acids (FAs) and the LXR ligand T0901317 a...
ORGANISM(S): Homo sapiens 
2010-06-23 | E-GEOD-18589 | biostudies-arrayexpress
ProteomicsEpithelial-mesenchymal transition shapes the lipotoxic response of colon cancer cells to palmitic acid
Saturated fatty acids such as palmitic acid (PA) can induce lipotoxic stress, whereas monounsaturated fatty acids like oleic acid (OA) often promote adaptive responses through lipid droplets (LDs) formation. Here, we reveal that epithelial-mesenchymal transition (EMT) profoundly influences the lipot...
ORGANISM(S): Homo sapiens (Human) 
2026-03-16 | PXD071641 | Pride
Emt markers  lipotoxicity  palmitic acid  lipid droplets  metabolic reprogramming. 
TranscriptomicsGene expression data from differentiated 3T3-L1 preadipocytes treated with Palmitic Acid, Stearic Acid, Palmitoleic Acid, or Oleic Acid
Saturated fatty acids (SFA) are widely thought to induce inflammation in adipose tissue (AT), while monounsaturated fatty acids (MUFA) are purported to have the opposite effect; however, it is unclear if individual SFA and MUFA behave similarly. Our goal was to examine adipocyte transcriptional netw...
ORGANISM(S): Mus musculus 
2012-11-13 | E-GEOD-42220 | biostudies-arrayexpress
ProteomicsMolecular insight into palmitic acid-induced hepatocellular carcinoma cell death
The accumulation of lipid is a histological and biochemical hallmark of obesity-associated hepato-steatosis.Moreover, growing evidenceindicatesthathigher free fatty acids (FFAs) level in hepatocytes affects a myriad of biological processes leading to excessive metabolic imbalance, increased reactive...
ORGANISM(S): Homo sapiens (Human) 
2022-07-16 | PXD029016 | Pride
Palmitic acid Phosphoproteomics. Lipotoxicity Hepg2 
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