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GenomicsSus scrofa strain:PAM cells
Sus scrofa strain:PAM cells Raw sequence reads
PRJNA352443 | ENA
TranscriptomicsSignaling from the secretory granule to the nucleus: Uhmk1 and PAM
Neurons and endocrine cells package peptides in secretory granules (large dense core vesicles; LDCVs) for storage and stimulated release. Studies of PAM, an essential secretory granule membrane enzyme, revealed a pathway that can relay information from secretory granules to the nucleus, resulting i...
ORGANISM(S): Mus musculus 
2010-07-29 | E-GEOD-22509 | biostudies-arrayexpress
GenomicsRNA-guided Location and Function of the Cas9 CRISPR Endonuclease in Mammalian Cells
The clustered regularly interspaced short palindromic repeat (CRISPR)-associated enzyme Cas9 is an RNA-guided nuclease that has been widely adapted for genome editing in eukaryotic cells. However, the in vivo target specificity of Cas9 is poorly understood and most studies rely on in silico predicti...
ORGANISM(S): Mus musculus 
2014-08-29 | E-GEOD-57650 | biostudies-arrayexpress
GenomicsRandomized PAM depeletion of NmeCas9
Randomized PAM depeletion of NmeCas9
PRJNA423256 | ENA
GenomicsRandomized PAM depletion of AsCas12a
Randomized PAM depletion of AsCas12a
PRJNA508763 | ENA
GenomicsVibrio Cholerae CRISPR-cas PAM requirements
Plasmids were constructed harboring protospacers that are perfect targets for spacers #4 and #21 of the array, but contain NNN (all possible PAM combinations) immediately upstream of the protospacer. The plasmids were introduced into V. cholerae with or without a functional CRISPR-cas system and ce...
ORGANISM(S): Vibrio cholerae 
2024-05-06 | E-MTAB-14044 | biostudies-arrayexpress
GenomicsRandomized PAM depletion of phylogenetically-diverse Cas12a nucleases
Randomized PAM depletion of phylogenetically-diverse Cas12a nucleases
PRJNA539942 | ENA
GenomicsMetapseudomonas otitidis strain:PAM-1
Metapseudomonas otitidis strain:PAM-1 Genome sequencing and assembly
PRJNA437548 | ENA
ProteomicsPAM complex sequesters from TIM translocon and becomes part of an insoluble protein fraction under protein folding stress
Upon mitochondrial dysfunction, mitophagy has been described to be activated by a breakdown of membrane potential leading to PINK1 accumulation on the outer membrane and engulfment of mitochondria for degradation. However, recent findings have indicated that mitophagy may also be triggered in the ab...
ORGANISM(S): Homo sapiens (Human) 
2022-09-03 | PXD022530 | Pride
Pam interactors Biotinylation-streptavidin-pull down Protein misfolding Turboid 
ProteomicsPAM complex sequesters from TIM translocon and becomes part of an insoluble protein fraction under protein folding stress
Upon mitochondrial dysfunction, mitophagy has been described to be activated by a breakdown of membrane potential leading to PINK1 accumulation on the outer membrane and engulfment of mitochondria for degradation. However, recent findings have indicated that mitophagy may also be triggered in the ab...
ORGANISM(S): Homo sapiens (Human) 
2022-09-03 | PXD022524 | Pride
Human Mitophagy Hela cell line Pam complex Lc-ms/ms 
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