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ProteomicsO-GlcNAc crosstalks with ADP-ribosylation via PARG
O-GlcNAc glycosylation is a prevalent protein post-translational modification (PTM) that occurs intracellularly. Previous investigations have demonstrated that O-GlcNAcylation crosstalks with phosphorylation and ubiquitination, but it is unclear whether it interplays with other PTMs. Here we studied...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD041119 | Pride
Hepatocellular carcinoma Poly(adp-ribosyl)ation O-glcnacylation Parg C-myc 
ProteomicsPARG is Essential for Pol-theta-Mediated DNA End-Joining by Removing Repressive Poly-ADP Ribose Marks
DNA polymerase theta (Pol-theta)-mediated end-joining (TMEJ) repairs DNA double-strand breaks and confers resistance to genotoxic agents. How Pol-theta is regulated at the molecular level to exert TMEJ remains unknown. We find that Pol-theta interacts with and is PARylated by PARP1 in vitro and in c...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000092839 | MassIVE
TranscriptomicsPaternal poly(ADP-ribose) metabolism modulates retention of inheritable sperm histones and early embryonic gene expression [Parg(110)_KO_sperm_MNase]
To achieve the extreme nuclear condensation necessary for sperm function, most histones are replaced with protamines during spermiogenesis in mammals. Mature sperm retain only a small fraction of nucleosomes, which are, in part, enriched on gene regulatory sequences, and recent findings suggest tha...
ORGANISM(S): Mus musculus 
2014-08-30 | E-GEOD-56281 | biostudies-arrayexpress
ProteomicsImpact of PARG Activity on the replisome composition
ADP-ribosylation is a posttranslational modification of proteins catalyzed by the PARP enzymes and removed by the enzyme PARG. In this project, we examined the impact of PARG activity on the recruitment of proteins to nascent DNA using iPOND-SILAC mass spectrometry. PARG was inhibited by treatment w...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD069827 | Pride
Ipond  adp-ribosylation  parg  dna replication 
ProteomicsPARG regulates the proteosomal degradation of TARG1
ADP-ribosylation (ADPr) is a reversible modification of macromolecules critical for the regulation of genome stability, stress responses, and proteostasis. While the roles of ADPr transferases such as PARP1/2 and TNKS1/2 are well established, the cellular functions and regulatory mechanisms of ADPr ...
ORGANISM(S): Homo sapiens (Human) 
2026-01-02 | PXD065407 | Pride
Parp Ubiquitination Proteome Adp-ribosylation Proteasomal degradation Dna damage 
ProteomicsTIMELESS haploinsufficiency induces a PARG-dependency that is rescued by nucleoside supplementation, thus mimicking intrinsic PARG inhibitor sensitivity of ovarian cancer cells
A subset of cancer cells are intrinsically sensitive to inhibitors targeting PARG, the poly(ADP-ribose) glycohydrolase that degrades PAR chains. Sensitivity is accompanied by persistent DNA replication stress, and can be induced by inhibition of TIMELESS, a replisome accelerator. However, the nature...
ORGANISM(S): Homo sapiens (Human) 
2024-06-28 | PXD049682 | Pride
Parg inhibitor Dna replication Adp-ribosylation dda Ethcd Hgsoc Replication stress Lc-ms/ms 
TranscriptomicsRNAi of human MCF7 cells knocked down for PARP-1 or PARGs
Poly(ADP-ribose) polymerase-1 (PARP-1) and poly(ADP-ribose) glycohydrolase (PARG) are enzymes that modify target proteins in the nucleus by the addition and removal, respectively, of ADP-ribose polymers. Although a role for PARP-1 in gene regulation has been well established, the role of PARG is le...
ORGANISM(S): Homo sapiens 
2009-10-30 | E-GEOD-12952 | biostudies-arrayexpress
GenomicsRNA sequencing data from PNX0010 clear renal cell carcinoma cells overexpressing PARG
RNA sequencing data from PNX0010 clear renal cell carcinoma cells overexpressing PARG
PRJNA764210 | ENA
TranscriptomicsExpression Analysis Upon PARP-1 or PARG Knockdown in MCF-7 Cells
Poly(ADP-ribose) polymerase-1 (PARP-1) and poly(ADP-ribose) glycohydrolase (PARG) are enzymes that modify target proteins in the nucleus by the addition and removal, respectively, of ADP-ribose polymers. Although a role for PARP-1 in gene regulation has been well established, the role of PARG is les...
ORGANISM(S): Homo sapiens 
2009-10-23 | GSE12952 | GEO
ProteomicsExtensive arginine phosphorylation in Staphylococcus aureus is influences by Stp1
Ever since the identification of the first protein-arginine kinase, McsB, in B. subtilis arginine phosphorylation gained more attention. However, the analysis of phosphorylations especially phosphormaidates comes along with several challenges. The sub-stoichiometric nature of protein phosphorylation...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 Escherichia coli Staphylococcus aureus 
2022-06-09 | PXD026981 | Pride
Fragmentation Staphylococcus aureus Stp1 Phosphorylation Arginine phosphorylation 
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