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MetabolomicsTargeting parkin-regulated metabolomic change in cartilage in the treatment of osteoarthritis
Articular cartilage degeneration, which may lead to osteoarthritis (OA), is a normal component of the aging process, but its underlying mechanism remains unknown. We found that chondrocytes exhibited an energy metabolism shift from glycolysis to oxidative phosphorylation (OXPHOS) during aging. Repro...
2024-07-17 | MTBLS9074 | MetaboLights
MetabolomicsTargeting parkin-regulated metabolomic change in cartilage in the treatment of osteoarthritis
Articular cartilage degeneration, which may lead to osteoarthritis (OA), is a normal component of the aging process, but its underlying mechanism remains unknown. We found that chondrocytes exhibited an energy metabolism shift from glycolysis to oxidative phosphorylation (OXPHOS) during aging. Repro...
2024-07-17 | MTBLS9079 | MetaboLights
MetabolomicsHuaban Tongmai Decoction ameliorates carotid artery atherosclerosis by inhibiting ferroptosis via the p53-Parkin mitophagy axis

Background: Carotid artery atherosclerosis (CAS), has exhibited an increasing incidence in recent years. Although Huaban Tongmai decoction (HBTMD) shows considerable therapeutic potential against CAS, the specific molecular mechanisms of its action remain incompletely defined.

Purpose: This...

2026-02-15 | MTBLS13908 | MetaboLights
TranscriptomicsMitochondrial contagion induced by Parkin deficiency in Drosophila hearts and its containment by suppressing mitofusin; germline Parkin knockout mouse hearts.
Dysfunctional Parkin-mediated mitophagic culling of senescent or damaged mitochondria is a major pathological process underlying Parkinson disease and a potential genetic mechanism of cardiomyopathy. Despite epidemiological associations between Parkinson disease and heart failure, the role of Parkin...
ORGANISM(S): Mus musculus 
2015-10-31 | E-GEOD-74517 | biostudies-arrayexpress
TranscriptomicsLoss-of-parkin function enhances cyclin D1 expression and AKT signalling and promotes glioblastoma cell proliferation
Mutations in the parkin gene, which encodes a ubiquitin ligase, are a major cause of autosomal recessive parkinsonism. Interestingly, parkin also plays a role in cancer as a putative tumor suppressor. Consistent with this, the gene is frequently targeted by deletion and inactivation in human maligna...
ORGANISM(S): Homo sapiens 
2012-03-15 | E-GEOD-29494 | biostudies-arrayexpress
ProteomicsParkin is an E3 ligase for the ubiquitin-like modifier Fat10 which inhibits Parkin activation and mitophagy
Parkin is an E3 ubiquitin ligase belonging to the RING-between-RING family. Mutations in the Parkin-encoding gene PARK2 are associated with familial Parkinson’s Disease. Here, we investigate the interplay between Parkin / Parkin-S65P and the inflammatory cytokine-induced ubiquitin-like modifier FAT1...
ORGANISM(S): Homo sapiens (Human) 
2021-03-05 | PXD022109 | Pride
Fat10 Mitophagy Parkinson’s disease Parkin Ubiquitin 
ProteomicsThe proteomic landscape of parkin-deficient and parkin-overexpressing rat nucleus accumbens: an insight into the role of parkin in methamphetamine use disorder
In recent years, methamphetamine (METH) misuse in the US has been rapidly increasing, and there is no FDA-approved pharmacotherapy for METH use disorder (MUD). We previously determined that ubiquitin-protein ligase parkin is involved in the regulation of METH addictive behaviors in rat models of MUD...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-08-04 | PXD065059 | Pride
Parkin  proteome  nucleus accumbens  mitochondria  methamphetamine 
ProteomicsTemporal Analysis of Protein Ubiquitylation and Phosphorylation During Parkin-dependent Mitophagy
Mitophagy, the selective degradation of mitochondria by autophagy, affects defective mitochondria following damage or stress. At the onset of mitophagy, parkin ubiquitylates proteins on mitochondrial outer membrane (MOM). While the role of parkin at the onset of mitophagy is well understood, less is...
ORGANISM(S): Homo sapiens (Human) 
2022-01-17 | PXD027586 | Pride
Quantitative proteomics Mitochondria Mitophagy Ubiquitin Parkin 
ProteomicsUbiquitination at the Parkin ubiquitin-like domain suggests a new mechanism for Parkin activation
The mitochondrial kinase PINK1 and the cytosolic ubiquitin ligase (E3) Parkin is involved in mitochondrial quality control. PINK1, which phosphorylates ubiquitin at serine 65 residue and the ubiquitin-like (Ubl) domain of Parkin at serine 65 residue, promotes the Parkin activation and translocation ...
ORGANISM(S): Homo Sapiens (human) 
2022-08-24 | PXD026554 | JPOST Repository
TranscriptomicsParkin-mediated mitophagy evokes perinatal cardiac mitochondria maturation
Exclusion of Parkin from mitochondria of perinatal cardiomyocytes interrupts structural and molecular transformations essential to normal perinatal-adult mitochondrial replacement. mRNA-sequencing from cardiac total RNA was performed at P1, P21 and 5-week stages of nontransgenic (ntg) and human-Mfn2...
ORGANISM(S): Mus musculus 
2015-12-04 | E-GEOD-68921 | biostudies-arrayexpress
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