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ProteomicsThe ubiquitin-like modifier FAT10 interferes with SUMO activation
In this study, the proteins SumoE1 and Fat10 or Fat10-AV mutant were crosslinked using the crosslinking reagent H12/D12 BS3 in order to determine specific interaction sites of Fat10 and SumoE1. Furthermore, quantitative chemical crosslinking coupled to mass spectrometry (q-XL-MS) was used to compare...
ORGANISM(S): Homo sapiens (Human) 
2019-10-08 | PXD012592 | Pride
Fat10 Q-xl-ms Xl-ms Sumoe1 
ProteomicsFAT10 is phosphorylated by IKKβ to inhibit the antiviral type-I interferon response
Type-I interferon (IFN-I) secretion provides a rapid host defense against infection with RNA-viruses. Upon entry into the host cell, the viral RNA triggers the activation of both RIG-I and TLR3 signaling pathways, ultimately leading to the production of type-I interferons. Since an exaggerated IFNa/...
ORGANISM(S): Homo sapiens (Human) 
2023-11-07 | PXD028918 | Pride
Fat10 Ubiquitin d Ubd Phosphorylation 
ProteomicsParkin is an E3 ligase for the ubiquitin-like modifier Fat10 which inhibits Parkin activation and mitophagy
Parkin is an E3 ubiquitin ligase belonging to the RING-between-RING family. Mutations in the Parkin-encoding gene PARK2 are associated with familial Parkinson’s Disease. Here, we investigate the interplay between Parkin / Parkin-S65P and the inflammatory cytokine-induced ubiquitin-like modifier FAT1...
ORGANISM(S): Homo sapiens (Human) 
2021-03-05 | PXD022109 | Pride
Fat10 Mitophagy Parkinson’s disease Parkin Ubiquitin 
TranscriptomicsDisruption of FAT10-MAD2 binding inhibits tumor progression
FAT10 interacts with MAD2 and caused tumor progression. The hypothesis tested in the present study was FAT10 induces tumor progression through its binding to MAD2 and Disruption of this binding restored its global gene expression
ORGANISM(S): Homo sapiens 
2014-12-01 | GSE54167 | GEO
GenomicsTranscriptomic analysis of gene diffrentially expressed after Pemafibrate treatment on the livers of mice overexpressing FAT10.
Transcriptomic analysis of gene diffrentially expressed after Pemafibrate treatment on the livers of mice overexpressing FAT10.
PRJNA999211 | ENA
UnknownUbiquitin like protein FAT10 repressed cardiac fibrosis after myocardial ischemic via mediating degradation of Smad3 dependent on FAT10-proteasome system.
Not available
S-EPMC9910007 | biostudies-literature
TranscriptomicsTranscriptomic analysis of gene diffrentially expressed after Pemafibrate treatment on the livers of mice overexpressing FAT10.
Livers from C57Bl6 male adult mice infected either with an adenovirus control (Ad-CTRL) or an adenovirus overexpressing FAT10 (Ad-FAT10) and treated or not with pemafibrate (Pema, vehicule CMC) were used to prepare RNA.
ORGANISM(S): Mus musculus 
2024-08-01 | GSE239392 | GEO
TranscriptomicsRBP CELF2 regulates acute leukemia development via FAT10-mTORC1 [RNA-seq]
We demonstrated that CELF2 regulates FAT10, and promotes mTORC1 signaling pathway activation in MLL-AF9-AML mice.
ORGANISM(S): Mus musculus 
2022-11-17 | GSE217988 | GEO
OtherRBP CELF2 regulates acute leukemia development via FAT10-mTORC1 [RIP-seq]
We demonstrated that CELF2 regulates FAT10, and promotes mTORC1 signaling pathway activation in MLL-AF9-AML mice.
ORGANISM(S): Homo sapiens 
2022-11-17 | GSE217987 | GEO
UnknownFAT10 modifies p53 and upregulates its transcriptional activity.
Not available
S-EPMC3133660 | biostudies-literature
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