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MetabolomicsPhosphoproteomic and Metabolomic Profiling Uncovers the Roles of CcPmk1 in the Pathogenicity of Cytospora chrysosperma

Pmk1, a highly conserved pathogenicity-related mitogen-activated protein kinase (MAPK) in pathogenic fungi, is phosphorylated and activated by MAP2K and acts as a global regulator of fungal infection and invasive growth by modulating downstream targets. However, the hierarchical CcPmk1 regulatory...

2022-07-11 | MTBLS4463 | MetaboLights
MetabolomicsUsing an NMR metabolomics approach to investigate the pathogenicity of amyloid-beta and alpha-synuclein
INTRODUCTION: The pathogenicity at differing points along the aggregation pathway of many fibril-forming proteins associated with neurodegenerative diseases is unclear. Understanding the effect of different aggregation states of these proteins on cellular processes is essential to enhance understand...
2018-06-11 | MTBLS455 | MetaboLights
MetabolomicsGut-derived metabolites drive Th17 cell pathogenicity in multiple sclerosis

The gut-brain axis is an emerging factor in promoting multiple sclerosis (MS). However, the underlying mechanisms and strategies to target this axis are not established. Here, we investigated how the gut environment influences myelin-specific Th17 cell pathogenicity. We used the adoptive Th17 cel...

2025-08-15 | MTBLS980 | MetaboLights
MetabolomicsPalmitic acid-mediated TLR4/NF-κB activation drives the pathogenicity of hypervirulent Bordetella pertussis MT28 lineage

Whooping cough resurged globally despite the widespread vaccination. A macrolide-resistant (MR) lineage carrying the high-virulence ptxP3 allele, ptxP3 MR-MT28 (MT28), has imposed a substantial burden on pertussis epidemics, while the underlying factors driving its prevalence remain unclear. Thus...

2025-06-21 | MTBLS12625 | MetaboLights
MetabolomicsTrcrtB regulates carotenoids biosynthesis, stress tolerance, conidiation and pathogenicity in the postharvest pink rot fungus, Trichothecium roseum

Trichothecium roseum is a highly destructive postharvest pathogenic fungus that causes pink mold rot in various fruits and leads to significant agricultural and economic losses. While Phytoene is known to be crucial for phytopathogens, its roles in postharvest fungi, remain largely obsc...

2026-07-22 | MTBLS15120 | MetaboLights
MetabolomicsAnalysis of the Mechanism of Pathogenicity Decline in Alternaria alternata f. sp. mali Mediated by the Mycovirus AaCV1
Apple leaf blotch disease caused by Alternaria alternata is a major fungal disease affecting apple production. To investigate the molecular mechanisms underlying virus-induced hypovirulence, metabolomic profiling was performed on A. alternata strains under different genetic and treatment conditions,...
2026-04-24 | MTBLS14366 | MetaboLights
TranscriptomicsComparative genomic hybridization of 94 Yersinia enterocolitica strains to identify genetic differences related to pathogenicity
Yersinia enterocolitica, an important cause of human gastroenteritis generally caused by the consumption of livestock, has traditionally been categorized into three groups with respect to pathogenicity, i.e., nonpathogenic (biotype 1A), low pathogenicity (biotypes 2 to 5), and highly pathogenic (bio...
ORGANISM(S): Yersinia enterocolitica 
2006-06-20 | E-BUGS-36 | biostudies-arrayexpress
TranscriptomicsMutation Mapping of 31 Streptococcus suis strains
Identification of Genes and Genomic Islands Correlated with High Pathogenicity through Tilling Microarray-Based Comparative Genomics in S. suis. Streptococcus suis is an important zoonotic pathogen that can cause meningitis and sepsis in both pigs and humans. S. suis isolates have been categorized ...
ORGANISM(S): Streptococcus suis 
2012-08-08 | E-GEOD-26052 | biostudies-arrayexpress
GenomicsInterleukin-23-induced transcription factor Blimp1 promotes pathogenicity of T helper 17 cells
Interleukin-23 (IL-23) is a pro-inflammatory cytokine required for the pathogenicity of T helper 17 (Th17) cells but the molecular mechanisms governing this process remain unclear. We identified the transcription factor Blimp-1 (Prdm1) as a key IL-23-induced factor that drove the inflammatory fun...
ORGANISM(S): Mus musculus 
2016-06-15 | E-GEOD-75724 | biostudies-arrayexpress
TranscriptomicsGene expression of Streptomyces turgidiscabies pathogenicity island
Gene expression in Streptomyces turgidiscabies pathogenicity island was studied after transferring cells into thaxtomin A inducing medium OBB using Agilent 60mer oligonucleotide array with probes designed for S.scabies and S.turgidiscabies. Gene expression study was used to confirm results of gene p...
ORGANISM(S): Streptomyces turgidiscabies 
2010-05-15 | E-GEOD-18375 | biostudies-arrayexpress
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