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TranscriptomicsComparative genomic hybridization of 94 Yersinia enterocolitica strains to identify genetic differences related to pathogenicity
Yersinia enterocolitica, an important cause of human gastroenteritis generally caused by the consumption of livestock, has traditionally been categorized into three groups with respect to pathogenicity, i.e., nonpathogenic (biotype 1A), low pathogenicity (biotypes 2 to 5), and highly pathogenic (bio...
ORGANISM(S): Yersinia enterocolitica 
2006-06-20 | E-BUGS-36 | biostudies-arrayexpress
TranscriptomicsMutation Mapping of 31 Streptococcus suis strains
Identification of Genes and Genomic Islands Correlated with High Pathogenicity through Tilling Microarray-Based Comparative Genomics in S. suis. Streptococcus suis is an important zoonotic pathogen that can cause meningitis and sepsis in both pigs and humans. S. suis isolates have been categorized ...
ORGANISM(S): Streptococcus suis 
2012-08-08 | E-GEOD-26052 | biostudies-arrayexpress
ProteomicsProteomic analysis of differentially expressed proteins in two Trypanosoma vivax strains with different patterns of virulence and pathogenicity in sheep.
Cattle trypanosomosis caused by Trypanosoma vivax is a widely distributed disease in Africa and Latin America. It causes significant losses in the livestock industry and is characterized by fever, parasitemia, anemia, lethargy, and weight loss. In this study we evaluated the virulence (capacity to m...
ORGANISM(S): Trypanosoma 
2019-10-17 | PXD013266 | Pride
Trypanosoma vivax  virulence  pathogenicity  proteomics  biomarkers 
MetabolomicsPhosphoproteomic and Metabolomic Profiling Uncovers the Roles of CcPmk1 in the Pathogenicity of Cytospora chrysosperma

Pmk1, a highly conserved pathogenicity-related mitogen-activated protein kinase (MAPK) in pathogenic fungi, is phosphorylated and activated by MAP2K and acts as a global regulator of fungal infection and invasive growth by modulating downstream targets. However, the hierarchical CcPmk1 regulatory...

2022-07-11 | MTBLS4463 | MetaboLights
GenomicsInterleukin-23-induced transcription factor Blimp1 promotes pathogenicity of T helper 17 cells
Interleukin-23 (IL-23) is a pro-inflammatory cytokine required for the pathogenicity of T helper 17 (Th17) cells but the molecular mechanisms governing this process remain unclear. We identified the transcription factor Blimp-1 (Prdm1) as a key IL-23-induced factor that drove the inflammatory fun...
ORGANISM(S): Mus musculus 
2016-06-15 | E-GEOD-75724 | biostudies-arrayexpress
TranscriptomicsGene expression of Streptomyces turgidiscabies pathogenicity island
Gene expression in Streptomyces turgidiscabies pathogenicity island was studied after transferring cells into thaxtomin A inducing medium OBB using Agilent 60mer oligonucleotide array with probes designed for S.scabies and S.turgidiscabies. Gene expression study was used to confirm results of gene p...
ORGANISM(S): Streptomyces turgidiscabies 
2010-05-15 | E-GEOD-18375 | biostudies-arrayexpress
TranscriptomicsAlterations in Gene Expression in Human Mesothelial Cells Correlate with Mineral Pathogenicity
Human mesothelial cells (LP9/TERT-1) were exposed to low and high (15 and 75 μm2/cm2 dish) equal surface area concentrations of crocidolite asbestos, nonfibrous talc, fine titanium dioxide (TiO2), or glass beads for 8 or 24 h. RNA was then isolated for Affymetrix microarrays, GeneSifter analysis and...
ORGANISM(S): Homo sapiens 
2011-09-18 | E-GEOD-14034 | biostudies-arrayexpress
TranscriptomicsmgrA acts as a repressor of the rlrA pathogenicity islet
Streptococcus pneumoniae normally resides in the human nasopharynx in a non-disease state. In response to yet unknown triggers it can descend to the lower respiratory tract and/or invade the bloodstream. Regulation and activation of virulence genes play essential roles in this process of disease d...
ORGANISM(S): Streptococcus pneumoniae 
2005-08-11 | E-GEOD-3107 | biostudies-arrayexpress
TranscriptomicsIntracellular hypoxia and heat shock response are essential requirements for amoebic pathogenicity and virulence
Amongst several amoebic species that colonize the human gut only Entamoeba histolytica is able to cause tissue damage in the intestine and other organs. Amoebic pathogenicity and virulence are commonly evaluated as the parasiteM-+s ability to produce liver abscesses in hamsters (ALAH). Some molecul...
ORGANISM(S): Entamoeba histolytica 
2015-03-02 | E-MTAB-1207 | biostudies-arrayexpress
TranscriptomicsSingle-cell transcriptional profiling of Th17 cells, differentiated in vitro for 48h [TGFB1_IL6-48h]
Extensive cellular heterogeneity exists within specific immune-cell subtypes classified as a single lineage, but its molecular underpinnings are rarely characterized at a genomic scale. Here, we use single-cell RNA-seq to investigate the molecular mechanisms governing heterogeneity and pathogenicity...
ORGANISM(S): Mus musculus 
2015-11-20 | E-GEOD-75110 | biostudies-arrayexpress
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