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ProteomicsPBK/TOPK mediates Ikaros, Aiolos and CTCF displacement from mitotic chromosomes and alters chromatin accessibility at selected C2H2-zinc finger protein binding sites
PBK/TOPK is a mitotic kinase implicated in haematological and non-haematological cancers. Here we show that the key haemopoietic regulators Ikaros and Aiolos require PBK-mediated phosphorylation to dissociate from chromosomes in mitosis. Eviction of Ikaros is rapidly reversed by addition of the PBK-...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-21 | PXD057898 | Pride
Chromosomes  mitosis  phosphorylation  pbk/topk  c2h2-zinc finger proteins 
ProteomicsPBK/TOPK mediates Ikaros, Aiolos and CTCF displacement from mitotic chromosomes and alters chromatin accessibility at selected C2H2-zinc finger protein binding sites
PBK/TOPK is a mitotic kinase implicated in haematological and non-haematological cancers. Here we show that the key haemopoietic regulators Ikaros and Aiolos require PBK-mediated phosphorylation to dissociate from chromosomes in mitosis. Eviction of Ikaros is rapidly reversed by addition of the PBK-...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-21 | PXD057894 | Pride
C2h2-zinc finger proteins Pbk/topk Chromosomes Mitosis Phosphorylation 
UnknownPBK/TOPK Expression Predicts Prognosis in Oral Cancer.
Not available
S-EPMC4964383 | biostudies-literature
UnknownCorrelation study of PBK/TOPK expression, prognosis, and immune infiltration in breast cancer.
Not available
S-EPMC12041462 | biostudies-literature
UnknownPBK/TOPK, a proliferating neural progenitor-specific mitogen-activated protein kinase kinase.
Not available
S-EPMC6725850 | biostudies-literature
UnknownPBK/TOPK Is a Favorable Prognostic Biomarker Correlated with Antitumor Immunity in Colon Cancers.
Not available
S-EPMC8869639 | biostudies-literature
UnknownPBK/TOPK Inhibitor Suppresses the Progression of Prolactinomas.
Not available
S-EPMC8815076 | biostudies-literature
TranscriptomicsTargeting PBK/TOPK decreases growth and survival of glioblastoma stem cells in vitro and attenuates tumor growth in vivo
Gene knockdown of PBK led to decreased proliferation and sphere formation in the GSC cultures. Treatment of cells with different concentrations of HI-TOPK-032 almost completely abolished growth and proliferation and elicited a large increase in apoptosis Total RNA isolated from GSC cultures featuri...
ORGANISM(S): Homo sapiens 
2015-06-16 | E-GEOD-53800 | biostudies-arrayexpress
TranscriptomicsTargeting PBK/TOPK decreases growth and survival of glioblastoma stem cells in vitro and attenuates tumor growth in vivo
Gene knockdown of PBK led to decreased proliferation and sphere formation in the GSC cultures. Treatment of cells with different concentrations of HI-TOPK-032 almost completely abolished growth and proliferation and elicited a large increase in apoptosis
ORGANISM(S): Homo sapiens 
2015-06-16 | GSE53800 | GEO
UnknownCytoplasmic, nuclear, and total PBK/TOPK expression is associated with prognosis in colorectal cancer patients: A retrospective analysis based on immunohistochemistry stain of tissue microarrays.
Not available
S-EPMC6171876 | biostudies-literature
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