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ProteomicsAnalysis of factors bound to native metaphase ESC chromosomes following purification by flow cytometry
Stem cells are able to self-renew and also generate differentiated progeny. How gene expression patterns are transmitted through mitosis remains unresolved. Conventional studies have relied upon rigorous cell-cycle-stage synchronisation to find factors in mitotic lysates that could ‘bookmark’ the ge...
ORGANISM(S): Mus musculus (Mouse) 
2020-06-15 | PXD015251 | Pride
Mitosis Stem cells Chromosomes Chromatin 
TranscriptomicsRapid de novo evolution of X chromosome dosage compensation in Silene latifolia, a plant with young sex chromosomes
Silene latifolia is a dioecious plant with heteromorphic sex chromosomes that have originated only ~10 MYA and is a promising model organism to study sex chromosome evolution in plants. Previous work suggests that S. latifolia XY chromosomes have gradually stopped recombining and the Y chromosome is...
ORGANISM(S): Silene latifolia 
2012-08-24 | E-GEOD-35563 | biostudies-arrayexpress
UnknownThe sequence of rice chromosomes 11 and 12, rich in disease resistance genes and recent gene duplications.
Not available
S-EPMC1261165 | biostudies-literature
ProteomicsPBK/TOPK mediates Ikaros, Aiolos and CTCF displacement from mitotic chromosomes and alters chromatin accessibility at selected C2H2-zinc finger protein binding sites
PBK/TOPK is a mitotic kinase implicated in haematological and non-haematological cancers. Here we show that the key haemopoietic regulators Ikaros and Aiolos require PBK-mediated phosphorylation to dissociate from chromosomes in mitosis. Eviction of Ikaros is rapidly reversed by addition of the PBK-...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-21 | PXD057898 | Pride
Chromosomes  mitosis  phosphorylation  pbk/topk  c2h2-zinc finger proteins 
ProteomicsMitotic chromatin proteomics - Proteomics analysis with a nano Random Forest approach reveals novel functional interactions regulated by SMC complexes on mitotic chromosomes
we used stable isotope labeling with amino acids in cell culture (SILAC) to compare the proteomes of mitotic chromosomes isolated from cell lines harboring conditional knockouts of members of the condensin (SMC2, CAP-H, CAP-D3), cohesin (Scc1/Rad21), and SMC5/6 (SMC5) complexes.
ORGANISM(S): Gallus gallus (Chicken) 
2016-05-31 | PXD003427 | Pride
Mitosis Smc Chromatin 
ProteomicsIDENTIFICATION OF SUMO-2/3 MODIFIED PROTEINS ASSOCIATED WITH MITOTIC CHROMOSOMES
Sumoylation is essential for progression through mitosis, but the specific protein targets and functions remain poorly understood. In this study, we used chromosome spreads to more precisely define the localization of SUMO-2/3 to the inner-centromere and protein scaffold of mitotic chromosomes. We a...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2014-10-07 | MSV000078890 | MassIVE
TranscriptomicsEffect of polymorphic Y chromosomes on XXY females
see publication, arrays from 4 XXY genotypes containing polymorphic Y chromosomes Dye swaps, loop design.
ORGANISM(S): Drosophila melanogaster 
2010-10-02 | E-GEOD-23612 | biostudies-arrayexpress
ProteomicsHbo1 and Msl complexes preserve differential compaction and H3K27me3 marking of active and inactive X chromosomes during mitosis
In mammals, chromosome-wide regulatory mechanisms ensure a balance of X-linked gene dosage between males (XY) and females (XX). In female cells, expression of genes from one of the two X-chromosomes is curtailed, with selective accumulation of Xist-RNA, Xist-associated proteins, specific histone mod...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-23 | PXD054014 | Pride
Proteomics Mitotic Mouse Chromosomes 
GenomicsNeandertal and Denisovan Y Chromosomes
Neandertal and Denisovan Y Chromosomes
PRJEB39390 | ENA
TranscriptomicsCell-cycle regulation of cohesin stability along fission yeast chromosomes
Sister chromatid cohesion is mediated by cohesin but the process of cohesion establishment during S phase is still enigmatic. Recent data indicate that in mammalian cells, cohesin binding to chromatin is dynamic in G1 but becomes stabilized during S phase. Whether the regulation of chromosomal cohes...
ORGANISM(S): Schizosaccharomyces pombe 
2007-11-30 | E-GEOD-8450 | biostudies-arrayexpress
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