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ProteomicsMitotic chromosome scaffold
Quantitative proteomics analysis of mitotic chromosome scaffold based on SILAC
ORGANISM(S): Gallus Gallus 
2018-10-07 | PXD007269 | JPOST Repository
Proteomicsmitotic chromosome scaffold SMC2ON vs OFF
Quantitative proteomics analysis of mitotic chromosome scaffold based on SILAC
ORGANISM(S): Gallus Gallus 
2018-10-07 | PXD008429 | JPOST Repository
ProteomicsPhosphosites of the yeast centrosome component Spc110 contribute to mitotic exit
Spc110 is an essential component of the spindle pole body (SPB), the yeast equivalent of the centrosome, that recruits the gamma-tubulin complex to the nuclear side of SPB to form the mitotic spindle. Here we identify two phosphosites (S11 and S36) in old (from maternal origin) Spc110. Yeast expres...
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast) 
2023-04-03 | PXD033085 | JPOST Repository
ProteomicsSelf-priming of Plk1 binding to BubR1 ensures accurate mitotic progression
Plk1 is a key mitotic kinase that localizes to distinct subcellular structures to promote accurate mitotic progression. Plk1 recruitment depends on direct interaction between polo-box domain (PBD) on Plk1 and PBD binding motif (PBD BM) on the interactors. However, recent study showed that PBD BM alo...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-10-31 | MSV000096264 | MassIVE
ProteomicsMitotic bookmarking redundancy by nuclear receptors mediates robust post-mitotic reactivation of the pluripotency network.
Mitotic bookmarking transcription factors (TFs) are thought to mediate rapid and accurate post-mitotic gene reactivation. However, the loss of individual bookmarking TFs often leads to the deregulation of only a small proportion of their mitotic targets, raising doubts on the significance and import...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-20 | PXD038950 | Pride
Nuclear receptors Pluripotency Esrrb Nr5a2 Es cells Mitotic bookmarking 
GenomicsPolycomb Group proteins are retained at specific sites on chromatin in mitosis
Epigenetic regulation of gene expression, including by Polycomb Group (PcG) proteins, may depend on heritable chromatin states but how these states can be propagated through mitosis is unclear. Using immunofluorescence and biochemical fractionation, we find PcG proteins associated with mitotic chrom...
ORGANISM(S): Drosophila melanogaster 
2013-01-04 | E-GEOD-38166 | biostudies-arrayexpress
TranscriptomicsMLL and Pol2 Chip-chip in interphase and mitotic arrested cells
Mixed Lineage Leukemia (MLL) and its metazoan Trithorax orthologs have been linked with the epigenetic maintenance of transcriptional activity. To identify mechanisms by which MLL perpetuates active transcription in dividing cells, we investigated its role during M-phase of the cell cycle. Unlike ot...
ORGANISM(S): Homo sapiens 
2010-05-19 | E-GEOD-19155 | biostudies-arrayexpress
TranscriptomicsMitotic Transcriptional Clearance of Actively Engaged Pol II Through Transcriptional Elongation Control
Chromatin is highly condensed and transcriptionally repressed during mitosis. Although it is established that some general transcription factors are inactivated by phosphorylation at mitosis, many details of mitotic transcriptional repression and its underlying mechanisms are largely unknown. Here, ...
ORGANISM(S): Homo sapiens 
2015-10-30 | E-GEOD-71848 | biostudies-arrayexpress
Transcriptomics5’-tag sequencing analysis of mouse mitotic chromosome RNA
As one of the most commonly recognized sub-cellular structures, mitotic chromosome structure and assembly is still lacking. Except the identified proteins and well known genomic composition, the identified mitotic chromosome RNA species is limited. We used a targeted protocol based on 5’-tag seque...
ORGANISM(S): Mus musculus 
2016-08-05 | E-MTAB-3810 | biostudies-arrayexpress
GenomicsFoxA1 binding in asynchronous and mitotic HUH7 cells
During mitosis, RNA polymerase and most transcription factors are excluded from the chromosomes and transcription ceases. The transcriptional re-activation of the genome, following mitosis, requires the re-setting of cell-type specific programs that were initially established during development. H...
ORGANISM(S): Homo sapiens 
2013-03-31 | E-GEOD-39241 | biostudies-arrayexpress
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