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TranscriptomicsPDE-4 inhibition alters gene expression and improves INH-mediated clearance of Mtb in rabbit lungs
Tuberculosis kills nearly 2 million people through out the world, every year. The outcome of M. tuberculosis infection is determined by the host and bacterial factors. A strong host immune response controls the growth of the bacilli effectively. However, in a host with suboptimal immune response,...
ORGANISM(S): Oryctolagus cuniculus 
2011-03-16 | E-GEOD-27992 | biostudies-arrayexpress
TranscriptomicsInvestigating the epigenetic effects of a prototype smoke-derived carcinogen in human cells
Global loss of DNA methylation and locus/gene-specific gain of DNA methylation are two distinct hallmarks of carcinogenesis. Aberrant DNA methylation is implicated in smoking-related lung cancer. In this study, we have comprehensively investigated the modulation of DNA methylation consequent to chro...
ORGANISM(S): Homo sapiens 
2010-04-29 | E-GEOD-21532 | biostudies-arrayexpress
TranscriptomicsFrancisella Expression Microarray Analysis
Francisella tularensis is a Gram-negative bacterium that is highly virulent in humans, causing the disease tularemia. F. novicida is closely related to F. tularensis and exhibits high virulence in mice, but is avirulent in healthy humans. A F. novicida-specific gene cluster (FTN0451-FTN0456) encodes...
ORGANISM(S): Francisella novicida 
2012-11-30 | E-GEOD-39647 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human mesenchymal stem cell-derived osteoblasts following RNAi knock down of phosphodiesterase 7 and 8A
Effects of phosphodiesterase 7 and 8A inhibition by RNA Interference on the gene expression of human mesenchymal stem cell-derived osteoblasts.
ORGANISM(S): Homo sapiens 
2008-12-12 | E-MEXP-1021 | biostudies-arrayexpress
TranscriptomicsDefining the Phosphodiesterase Superfamily Members in Rat Brain Microvessels
A filtration method followed by microarray analyses allows PDE components to be identified in brain microvessels, and confirmed that PDE4D and PDE5A are the primary forms expressed in rat brain microvessels. Adult male F344 rats were sacrificed and blocks of the cerebral cortex and infratentorial ar...
ORGANISM(S): Rattus norvegicus 
2012-02-01 | E-GEOD-35285 | biostudies-arrayexpress
ProteomicsMutagenesis of Key Phosphodiesterases in Toxoplasma gondii Demonstrates the Plasticity and Therapeutic Potential of Cyclic Nucleotide Signaling
Cyclic nucleotide signaling is pivotal to the asexual growth of T. gondii; however, little do we know about its counter-regulation in this parasite. We identified 18 phosphodiesterase (PDE1-18) enzymes, most of which form apicomplexan-specific clades and lack typical regulatory motifs found in mamma...
ORGANISM(S): Cellular Organisms 
2023-02-22 | PXD032173 | JPOST Repository
ProteomicsAnalyses of PDE-regulated phosphoproteomes reveal unique and specific cAMP signaling modules in T cells
Specific functions for different cyclic nucleotide phosphodiesterases (PDEs) have not yet been identified in most cell types. Conventional approaches to study PDE function typically rely on global cAMP measurements, general increases in cAMP- dependent protein kinase (PKA) activity, or activity of ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-05-27 | MSV000081115 | MassIVE
TranscriptomicsIncreased Expression of Phosphodiesterase Type 5 Promotes the Invasive Potential of Breast Cancer Cells: Implications for Targeted Therapy.
Purpose: By catalyzing hydrolysis of cyclic guanosine monophosphate, phosphodiesterase (PDE) 5 is a critical regulator of its concentration and biological effects in different (patho)physiological processes, including cancers. Being PDE5 a known druggable target, we investigated the clinical signifi...
ORGANISM(S): Homo sapiens 
2016-02-01 | E-MTAB-3801 | biostudies-arrayexpress
TranscriptomicsTissue profiling of phosphodiesterases
We used microarrays to detail the global programme of gene expression underlying cellularisation and identified distinct classes of up-regulated genes during this process. 24 human tissues plus one control pool were selected to investigate tissue-specific transcription and RNA splicing of the human ...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-5983 | biostudies-arrayexpress
UnknownRapid Screening and Quantitative Determination of Illegal Phosphodiesterase Type 5 Inhibitors (PDE-5i) in Herbal Dietary Supplements.
Not available
S-EPMC8116155 | biostudies-literature
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