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TranscriptomicsSeparation of mouse ES cell-derived mesodermal cells based on the expression of Flk1, PDGFRa and CAR.
We found that mouse ES cell-derived Flk1+ cells could be subdivided into three population by the expression of PDGFRa and CAR (Flk1+PDGFRa-CAR-, Flk1+PDGFRa-CAR+, and Flk1+PDGFRa+CAR+). Therefore, global gene expression analysis was perfomed by microarray to characterize these mesodermal subsets. ...
ORGANISM(S): Mus musculus 
2015-05-22 | E-GEOD-58170 | biostudies-arrayexpress
TranscriptomicsNovel Oncogenic PDGFRA Mutations in Pediatric High-Grade Gliomas
The outcome for children with high-grade gliomas (HGG) remains dismal, with a two-year survival rate of only 10-30%. Approximately half of pediatric HGGs are diffuse intrinsic pontine glioma (DIPG), a brainstem tumor that arises almost exclusively in children. Genome-wide analyses of copy number i...
ORGANISM(S): Mus musculus 
2013-11-06 | E-GEOD-46190 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-seq of Pdgfra+/Sca1+/Cd31- mouse cardiac cells
Adult mice hearts contain a population of resident mesenchymal stem cell (MSC)-like cells called cardiac colony forming units-fibroblast (cCFU-F). The cCFU-F are housed in a population of non-muscle cardiac cells that are Pdgfra+/Sca1+/Cd31- (S+P+ fraction). The goal of this experiment was to profil...
ORGANISM(S): Mus musculus 
2019-03-28 | E-MTAB-7365 | biostudies-arrayexpress
TranscriptomicsCells isolated from diaphragm of mdx mouse: satellite cells vs. PDGFRa+ cells
Transcriptional profiling of mouse skeletal muscle-derived cells comparing satellite cells with PDGFRa+ cells. Satellite cells and PDGFRa+ cells were directly isolated from diaphragm of dystrophic mdx mouse by FACS. Two-condition experiment, satellite cells vs. PDGFRa+ cells. Freshly isolated. One r...
ORGANISM(S): Mus musculus 
2011-12-08 | E-GEOD-25258 | biostudies-arrayexpress
ProteomicsEndothelial-secreted Endocan protein activates PDGFRa signaling and regulates vascularity, radioresistance, and regional phenotype in glioblastoma
Extensive neovascularization is a hallmark of glioblastoma (GBM). In addition to supplying oxygen and nutrients, vascular endothelial cells provide trophic support to GBM cells via paracrine signaling. Here we report that Endocan (ESM1), an endothelial-secreted proteoglycan, confers enhanced prolife...
ORGANISM(S): Homo sapiens (Human) 
2024-12-04 | PXD057635 | Pride
Brain cancer  glioma  glioblastoma  endocan  esm1  pdgfra  myc  angiogenesis  endothelial cells  radioresistance 
TranscriptomicsComparison of Flk-1+/PDGFRa+(Flk-1PRa+(DP)) population from Etv2Het vs Etv2KO ES cells
Screening for genes regulated by Etv2 within Flk-1+/PDGFRa+ ES derived mesoderm.Microarray analysis performed to screen for the candidate genes regulated by Etv2. TT2 ES cells differentiated on OP9 feeder cells were sorted using Flk-1 and PDGFRa antibodies.Gene expressions from these two population...
ORGANISM(S): Mus musculus 
2011-08-30 | E-GEOD-31744 | biostudies-arrayexpress
GenomicsmiRNA Expression in PDGFRA Mutant GISTs
miRNA Expression in PDGFRA Mutant GISTs
PRJNA890223 | ENA
ProteomicsStructure-based Scaffold Hopping Reveals Strategies to Overcome Oncogenic KIT and PDGFRA Mutation-Driven Drug-Resistance in GIST
Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract. Current tyrosine kinase inhibitors (TKIs) targeting oncogenic KIT and PDGFRA have improved patient outcomes, yet off-target toxicities and drug resistance mutations remain major clinical chal...
ORGANISM(S): Homo sapiens (Human) 
2026-08-03 | PXD077574 | Pride
Selectivity profiling Gist Pdgfra Kit Drug resistance Kinobeads 
TranscriptomicsIdentification of common features proffered by KIT and PDGFRA mutations in gastro-intestinal stromal tumors
Mutations in KIT proto-oncogene receptor tyrosine kinase (KIT) or platelet derived growth factor receptor alpha (PDGFRA) are responsible for more than 85% of the gastrointestinal stromal tumors (GIST). The introduction of imatinib in the therapy scheme of GIST revolutionized the patient outcome. Unf...
ORGANISM(S): Homo sapiens 
2017-07-05 | E-MTAB-4548 | biostudies-arrayexpress
TranscriptomicsChanges of miRNAs during osteogenic differentiation of PDGFRa+ mesenchymal progenitors derived from human skeletal muscle
Comprehensive analyses of miRNAs expression were performed using miRNA microarrays during osteogenic differentiation of PDGFRa+ mesenchymal progenitors isolated from human skeletal muscle to identify miRNAs that are involved in osteogenesis of PDGFRa+ mesenchymal progenitors. PDGFRa+ mesenchymal pro...
ORGANISM(S): Homo sapiens 
2013-08-01 | E-GEOD-39361 | biostudies-arrayexpress
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