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MetabolomicsDelayed gut microbiota maturation in the first year of life is a hallmark of pediatric allergic disease
Allergic diseases affect millions of people worldwide. An increase in their prevalence has been associated with alterations in the gut microbiome, i.e., the microorganisms and their genes within the gastrointestinal tract. Maturation of the infant immune system and gut microbiota occur in parallel; ...
2024-10-24 | MTBLS7919 | MetaboLights
TranscriptomicsTranscription profiling of Multilineage Dysplasia (MLD) in AML correlates with MDS-related cytogenetic abnormalities and a prior history of MDS or MDS/MPN but has no independent prognostic relevance
Full Title: Multilineage Dysplasia (MLD) in AML correlates with MDS-related cytogenetic abnormalities and a prior history of MDS or MDS/MPN but has no independent prognostic relevance: A comparison of 408 cases classified as “AML not otherwise specified” or “AML with myelodysplasia-related changes” ...
ORGANISM(S): Homo sapiens 
2011-01-01 | E-GEOD-21261 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human 164 MDS, 202 AML and 69 non-leukemia bone marrow samples to develop a gene array prediction of AML transformation in MDSm subset of MILE study data
Microarray-based classifiers and prognosis models identify subgroups with distinct clinical outcomes and high risk of AML transformation of myelodysplastic syndrome (MDS); An array-based Diagnostic Classifier (DC) model, developed for and evaluated during the MILE study, correctly identified ~50% of...
ORGANISM(S): Homo sapiens 
2009-06-22 | E-GEOD-15061 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of pediatric myelodysplastic syndrome (MDS) characterizes disease subtype and time to progression into acute myeloid leukemia (AML)
Identification of relevant subgroups in childhood MDS patients by gene expression analysis and gene involve in progression into AML Class comparison between different subgroups of pediatric MDS (class risk, classification subtype)
ORGANISM(S): Homo sapiens 
2012-02-29 | E-GEOD-29326 | biostudies-arrayexpress
TranscriptomicsAltered Hematopoietic Cell Gene Expression Precedes Development of Therapy-Related Myelodysplasia and Identifies Patients at Risk
Therapy-related myelodysplasia or acute myeloid leukemia (t-MDS/AML) is a lethal complication of cancer treatment. Although t-MDS/AML development is associated with known genotoxic exposures, its pathogenesis is not well understood and methods to predict risk of development of t-MDS/AML in individua...
ORGANISM(S): Homo sapiens 
2011-12-12 | E-GEOD-23025 | biostudies-arrayexpress
GenomicsWhole exome sequencing of human MDS/AML OCI-M2 and patient-derived bone marrow cell lines treated with 5-azacytidine
The whole exome sequencing experiment is part of the study: “Analysis of 5-azacytidine resistance models reveals a set of targetable pathways”. In the study we generated myelodysplastic syndrome/acute myeloid leukemia (MDS/AML) OCI-M2 cell lines as well as patient-derived bone marrow cell lines that...
ORGANISM(S): Homo sapiens 
2022-05-02 | E-MTAB-11172 | biostudies-arrayexpress
TranscriptomicsDifferential Gene Expression Profiles in CD34+ Myelodysplastic Syndrome Marrow cells to Disease Subtype and Progression
Microarray analysis with 40,000 cDNA gene chip arrays determined differential gene expression profiles (GEPs) in CD34+ marrow cells from myelodysplastic syndrome (MDS) patients compared to normal individuals. Using focused bioinformatics analyses, we found 1175 genes significantly differentially ex...
ORGANISM(S): Homo sapiens 
2009-10-31 | E-GEOD-18366 | biostudies-arrayexpress
ProteomicsIdentification of SAMD9 and SAMD9L interactome in HEK293T cells
Recently, heterozygous germline mutations were identified in sterile alpha motif (SAM) domain-9 (SAMD9) and its paralog, SAMD9-like (SAMD9L) in children with monosomy 7 mediated MDS. Expression of SAMD9 and SAMD9L is induced by interferons and other inflammatory stimuli and causes reduced cell divis...
ORGANISM(S): Homo sapiens (Human) 
2021-03-24 | PXD020018 | Pride
Samd9  samd9l  pediatric mds  proteomics 
GenomicsTargeted deep sequencing on Pediatric MDS
Targeted NGS using custom panels with SAMD9, SAMD9L genes and 22 single nucleotide polymorphisms (SNP) on chromosome 7q (allele frequency >35% in all ethnic sub-populations in gnomAD) (Ampliseq #IAD10417) was performed in 667/669 cases. Additionally, 559 cases were sequenced using 28 pediatric MDS g...
EGAS00001005431 | EGA
TranscriptomicsMyelodysplastic syndrome: NUP98-HoxD13 (NHD13) expression effect on hematopoietic stem cells
Analysis of Lin-c-Kit+Sca-1- haematopoietic stem cells (HSCs) expressing the Nup98-HoxD13 (NHD13) fusion gene. NHD13 induces myelodysplastic syndrome (MDS) in mice. Results provide insight into the molecular basis of the myelodysplastic phenotype WT mouse HSCs were compared to an NHD13 mutant sequen...
ORGANISM(S): Mus musculus 
2016-07-03 | E-GEOD-66264 | biostudies-arrayexpress
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