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ProteomicsLibrary-1 Hybridization
High-throughput microarray analysis of a 1296-member PNA-encoded peptide library for the identification of short homing-peptides as tools for selective delivery into specific cell types.
ORGANISM(S): Homo sapiens 
2011-08-10 | E-MEXP-3101 | biostudies-arrayexpress
ProteomicsMesoporous Silica Nanoparticles-based Formulations for Enhanced Oral Delivery of Peptide Drugs: a Case Study on Insulin
Peptide drugs have revolutionized modern medicine owing to their high potency, selectivity, and excellent tolerability. However, oral delivery remains limited, and most peptide drugs are administered parenterally due to their inherent instability to proteolytic digestion and poor ability to cross ga...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD074176 | Pride
Mesoporous silica nanoparticles (msn)  peptide delivery  peptide drugs  proteomics Insulin 
TranscriptomicsCollagen-binding C-type natriuretic peptide enhances chondrogenesis and osteogenesis
To enhance local drug delivery and therapeutic efficacy, we developed a novel synthetic protein by fusing a collagen-binding domain (CBD) to C-type natriuretic peptide (CNP), termed CBD-CNP. CBD-CNP localized to collagen-rich tissues and promoted bone elongation.
ORGANISM(S): Mus musculus 
2025-12-05 | E-MTAB-16154 | biostudies-arrayexpress
ProteomicsA proteomic barcoding platform for macromolecular screening and delivery
To address the delivery barriers of macromolecular therapeutics, we sought to develop high-throughput peptide barcoding platform as a homogeneous method for macromolecular screening. Implemented in open-source algorithms, BarcodeBabel and PeptideBabel, this approach permits the design of libraries o...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD048412 | Pride
Barcodebabel Barcoding Macromolecular drug delivery Peptidebabel 
ProteomicsRNA Encoded Peptide Barcodes Enable Efficient in vivo Screening of RNA Delivery Systems
LNPs have been demonstrated to hold great promise for the clinical advancement of RNA therapeutics. Continued exploration of LNPs for application in new disease areas requires identification and optimisation of leads in a high throughput way. Currently available high throughput in vivo screening pla...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD053797 | Pride
Lnp Proteomics Rna In vivo High throughput Barcodes 
TranscriptomicsDesign of a novel highly efficient peptide-based siRNA-delivery vector, PepFect6
While small interfering RNAs (siRNAs) have been rapidly appreciated to induce gene silencing, efficient vectors for primary cells and for systemic in vivo delivery are lacking. We here present a novel chemically modified cell-penetrating peptide named PepFect6 (PF6) for efficient delivery of siRNAs ...
ORGANISM(S): Homo sapiens 
2009-12-31 | GSE19702 | GEO
UnknownSPA: a peptide antagonist that acts as a cell-penetrating peptide for drug delivery.
Not available
S-EPMC6968712 | biostudies-literature
UnknownOral delivery of peptide therapeutics in infants: Challenges and opportunities.
Not available
S-EPMC8178217 | biostudies-literature
UnknownTumor-targeted delivery of siRNA using fatty acyl-CGKRK peptide conjugates.
Not available
S-EPMC5522445 | biostudies-literature
ProteomicsProteomics and metabolomics of different delivery modes in human pregnancy
This project investigates the impact of different delivery modes and labor on maternal and neonatal health by analyzing 40 participants, including 16 spontaneous vaginal deliveries (VD), 16 prelabor cesarean deliveries (CS), and 8 intrapartum cesarean sections (Intra_CS). Using label-free proteomics...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD058131 | Pride
Proteomics   metabolomics   delivery modes 
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