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MetabolomicsFetal Metabolic Stress Disrupts Immune Homeostasis and Induces Proinflammatory Responses in Human Immunodeficiency Virus Type 1- and Combination Antiretroviral Therapy-Exposed Infants
Increased morbidity and fetal growth restriction are reported in uninfected children born to human immunodeficiency virus type 1 (HIV-1)–infected women treated with antiretroviral (ARV) therapy. Viruses and/or pharmacological interventions such as ARVs can induce metabolic stress, skewing the cell’s...
2018-06-06 | MTBLS449 | MetaboLights
MetabolomicsCysteamine-bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis
Nephropathic cystinosis is a severe monogenic kidney disorder caused by mutations in CTNS, encoding the lysosomal transporter cystinosin, resulting in lysosomal cystine accumulation. The sole treatment, cysteamine, slows down the disease progression, but does not correct the established renal proxim...
2021-06-24 | MTBLS2538 | MetaboLights
TranscriptomicsGene expression profiling in hepatic tissue of newly weaned pigs fed pharmacological zinc supplemented diets
Zinc (Zn) is an essential trace element for all life forms. Zn supplementation has been used to treat diarrheal disease in children, and in the U.S. swine industry at pharmacological levels to promote growth and fecal consistency, but underlying mechanisms explaining these beneficial effects remain ...
ORGANISM(S): Sus scrofa 
2008-10-02 | E-GEOD-11972 | biostudies-arrayexpress
TranscriptomicsPharmacogenomics of IFNb therapy
This experiment set is used for the manuscript entitled: Pharmacogenomics of Interferon-b therapy in multiple sclerosis: Baseline IFN signature determines pharmacological differences between patients. In this study we generated and analyzed pre- and post- IFNb treatment gene expression patterns of R...
ORGANISM(S): Homo sapiens 
2008-04-01 | E-GEOD-10655 | biostudies-arrayexpress
TranscriptomicsEffect of pharmacological inhibition of ASBT on bile composition and sclerosing cholangitis in mdr2 knockout mice
We report the effect of a potent pharmacological inhibition of ASBT in mdr2 -/- mice, compared to genetic and treatment controls using RNA-sequencing. Through quantification of mRNA in liver samples, we found significant upregulation of anti-inflammatory and anti-fibrotic gene signatures in mdr2-/-...
ORGANISM(S): Mus musculus 
2016-02-17 | E-GEOD-66231 | biostudies-arrayexpress
TranscriptomicsIdentification of targets for rational pharmacological therapy in childhood craniopharyngioma
Introduction: Pediatric adamantinomatous craniopharyngioma (ACP) is a histologically benign but clinically aggressive brain tumor that arises from the sellar/suprasellar region. Despite a high survival rate with current surgical and radiation therapy (75-95% at 10 years), ACP is associated with debi...
ORGANISM(S): Homo sapiens 
2015-04-18 | E-GEOD-68015 | biostudies-arrayexpress
GenomicsPharmacological inhibition of METTL1 as a therapy against solid and haematological cancers [RNA-Seq]
Pharmacological inhibition of METTL1 as a therapy against solid and haematological cancers [RNA-Seq]
PRJNA1372688 | ENA
GenomicsPharmacological inhibition of METTL1 as a therapy against solid and haematological cancers [Ribo-Seq]
Pharmacological inhibition of METTL1 as a therapy against solid and haematological cancers [Ribo-Seq]
PRJNA1291211 | ENA
GenomicsTargeted pharmacological therapy restores β-cell function for diabetes remission
Targeted pharmacological therapy restores β-cell function for diabetes remission
PRJNA528110 | ENA
ProteomicsPharmacological induction of selective endoplasmic reticulum retention as a novel strategy for cancer therapy
We analysed the difference in the surface proteome of human cells that were either subjected to ER stress (induced by thapsigargin (Tg)) only or were additionally treated with a pharmacological inhibitor against the eIF2α kinase PERK, which is localized in the endoplasmic reticulum. Compared to sin...
ORGANISM(S): Homo sapiens (Human) 
2020-03-02 | PXD014709 | Pride
Lc-ms Human Plasma membrane 
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