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MetabolomicsEpithelial-Cell-Derived Phospholipase A2 Group 1B Is an Endogenous Anthelmintic
Immunity to intestinal helminth infections has been well studied, but the mechanism of helminth killing prior to expulsion remains unclear. Here we identify epithelial-cell-derived phospholipase A2 group 1B (PLA2g1B) as a host-derived endogenous anthelmintic. PLA2g1B is elevated in resistant mice an...
2018-08-13 | MTBLS523 | MetaboLights
TranscriptomicsExpression analysis with Phospholipase C over expression
The regulation of phospholipid biosynthesis in Saccharomyces cerevisiae through cis-acting upstream activating sequence inositol (UASino) and trans-acting elements, such as the INO2-INO4 complex and OPI1 by inositol supplementation in growth is thoroughly studied. In this study, we provide evidence ...
ORGANISM(S): Saccharomyces cerevisiae 
2012-09-01 | E-GEOD-35745 | biostudies-arrayexpress
TranscriptomicsExpression analysis with Phospholipase C over expression
The regulation of phospholipid biosynthesis in Saccharomyces cerevisiae through cis-acting upstream activating sequence inositol (UASino) and trans-acting elements, such as the INO2-INO4 complex and OPI1 by inositol supplementation in growth is thoroughly studied. In this study, we provide evidence ...
ORGANISM(S): Saccharomyces cerevisiae 
2012-04-23 | E-GEOD-35677 | biostudies-arrayexpress
Transcriptomicsedelfosine and wortmannin effect at 22°c and 4°c-PI4-kinase and phospholipase C signaling in cold response
rs09-04_plc_2 - edelfosine and wortmannin effect at 22°c and 4°c - Is there an overlap between PI4-kinase and phospholipase C signaling in cold response ? - Experiments were carried out with Columbia suspension cells. Cells were treated or not with edelfosine (PLC inhibitor) or wortmannin (PI4-kinas...
ORGANISM(S): Arabidopsis thaliana 
2010-08-01 | E-GEOD-19850 | biostudies-arrayexpress
ProteomicsDynamics of allosteric regulation of the phospholipase C-gamma isoform
we used hydrogen deuterium exchange masss spec (HDX-MS) to define the exchange kinetics of PLC-y1 as it interacts with the kinase domain of FGFR1, and liposomes containing PIP2, in order to understand how PLC-y isozymes operate at membranes. We show that the binding of FGFR1k to PLC-y1 increases deu...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-06-14 | PXD030492 | Pride
Hdxms Plc 
GenomicsDiagnosis of Alzheimer's disease specific phospholipase c gamma-1 SNV by deep-learning based approach for high throughput screening
Diagnosis of Alzheimer's disease specific phospholipase c gamma-1 SNV by deep-learning based approach for high throughput screening
PRJNA635365 | ENA
UnknownPhospholipase C-γ as a Potential Therapeutic Target for Graves' Orbitopathy.
Not available
S-EPMC10765002 | biostudies-literature
UnknownMechanism of phosphorylation-induced activation of phospholipase C-gamma isozymes.
Not available
S-EPMC2975207 | biostudies-literature
TranscriptomicsMisregulation of the broad-range phospholipase C activity increases the susceptibility of Listeria monocytogenes to intracellular killing by neutrophils
Listeria monocytogenes is a facultative intracellular bacterial pathogen that tightly regulates the activities of various virulence factors during infection. A mutant strain (the plcBM-NM-^Tpro mutant) that has lost the ability to control the activity of a phospholipase C (PC-PLC) is attenuated a hu...
ORGANISM(S): Mus musculus 
2013-08-14 | E-GEOD-49820 | biostudies-arrayexpress
UnknownCharacterization of phospholipase C gamma enzymes with gain-of-function mutations.
Not available
S-EPMC2755714 | biostudies-literature
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