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TranscriptomicsExpression data from hepatitis E virus inoculated PLC/PRF/5 cells
Hepatitis E virus (HEV) is an important causative pathogen of acute hepatitis. Because of the absence of an in vitro culture system for HEV, research has been greatly impeded. And interaction between HEV and host cells was mainly studied by tansfection/transinfection system, such as Adeno virus tran...
ORGANISM(S): Homo sapiens 
2014-01-01 | E-GEOD-53731 | biostudies-arrayexpress
TranscriptomicsRNAi knock down of Hepatitis B viral gene expression in human HepG2.2.15 or PLC/PRF/5 cells
Gene expression profiling comparisons of HepG2.2.15 or PLC/PRF/5 cells either mock (M) transfected or transfected with 0.2 microM S2 RNA or Scrambled (SCR) siRNA were carried out in duplicate 48 hours after transfection. The experiments were carried out in duplicate (a and b). The following combinat...
ORGANISM(S): Homo sapiens 
2005-11-03 | E-SMDB-2880 | biostudies-arrayexpress
ProteomicsPLC-γ1 Can Regulate T-Cell Activation by Positive and Negative Feedback via Lck
Phospholipase C gamma 1 (PLC-γ1) occupies a critically important position in the T cell signaling pathway. While its functions as a regulator of both Ca2+ signaling and PKC-family kinases are well characterized, PLC-γ1’s role in the regulation of early T cell receptor signaling events is incomplete....
ORGANISM(S): Homo sapiens (Human) 
2017-06-28 | PXD005165 | Pride
Phosphoproteomics Phospholipase c Tcr signaling Plc-γ1 Lc-msms 
TranscriptomicsInhibition of the PI-PLC by U73122
au13-01_pi-plc What are the genes that are regulated by basal PI-PLC? Arabidopsis thaliana cells in suspension (5-days old). Cultivated in environment (middle) Gamborg+2,4-D. Added inhibitors 4 hr before extraction of the RNAs. We try to determine the role of phospholipases C ( PI-PLC) in the contro...
ORGANISM(S): Arabidopsis thaliana 
2013-09-01 | E-GEOD-46941 | biostudies-arrayexpress
ProteomicsSILAC proteomic analysis of secreted proteins from PLC cells expressing EV or PRSS35
Since PRSS35 only exhibited tumor suppressive effects in mice, but not in the cultured cells, we speculated that some factors in the microenvironment are affected by PRSS35. To explore this possibility, we performed SILAC proteomic analysis in conjunction with RNA sequencing to identify secreted pro...
ORGANISM(S): Homo sapiens (Human) 
2023-02-15 | PXD033579 | Pride
Ev Prss35 Plc Secreted proteins 
ProteomicsDynamics of allosteric regulation of the phospholipase C-gamma isoform
we used hydrogen deuterium exchange masss spec (HDX-MS) to define the exchange kinetics of PLC-y1 as it interacts with the kinase domain of FGFR1, and liposomes containing PIP2, in order to understand how PLC-y isozymes operate at membranes. We show that the binding of FGFR1k to PLC-y1 increases deu...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-06-14 | PXD030492 | Pride
Hdxms Plc 
GenomicsTargeted next generation sequencing of genomic DNA from PLC, JEG3 and JEG3R cells
A comparison between a human placental cell line (3A sub E placental, aka, PLC), human choriocarcinoma methotrexate-sensitive JEG3, and methotrexate-resistant JEG3R. This comparison focused on genomic 'hot spot' regions that are frequently mutated in human cancer genes.
ORGANISM(S): Homo sapiens 
2022-02-19 | E-MTAB-11432 | biostudies-arrayexpress
TranscriptomicsThe effect of PLC inhibitor on cold responsive transcriptome.
Identification of genes induced with the cold via inhibition of the phospholipase C - To answer this question we chose a pharmacological approach. We decided to use molecules that are going to inhibit PLC. U73343 is an inactive homolog of U73122 (inhibitor of the phospholipase C pathway). Keywords: ...
ORGANISM(S): Arabidopsis thaliana 
2010-05-22 | E-GEOD-13295 | biostudies-arrayexpress
GenomicsCDC7 inhibition in PLC/PRF/5 cells
CDC7 inhibition in PLC/PRF/5 cells
PRJNA761976 | ENA
GenomicsSubstrates of PRSS35 in PLC cells
Substrates of PRSS35 in PLC cells
PRJNA830851 | ENA
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