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MetabolomicsMulti-omics and biophysical phosphoproteomics uncover functional phosphorylation networks of BRAFV600E-driven signaling

Dysregulated kinase activity drives oncogenic signalling, perturbs cellular homeostasis, and promotes tumour progression. Despite major success in targeting kinases therapeutically, the downstream consequences of kinase inhibition and the mechanisms underlying drug resistance remain incompletely ...

2025-12-09 | MTBLS7390 | MetaboLights
TranscriptomicsChIP-chip study aimed at the identification of the repertoire of FOXC2 binding sites affected by the loss of FOXC2 phosphorylation in primary human lymphatic endothelial cells (LECs)
Chromatin immunoprecipitation microarray (ChIP-chip) study using anti-Myc (9E10) antibodies and primary human lymphatic endothelial cells (LECs) transduced with recombinant adenoviruses expressing wild type or phosphorylation-deficient Myc-tagged FOXC2.
ORGANISM(S): Homo sapiens 
2013-07-13 | E-MTAB-596 | biostudies-arrayexpress
ProteomicsComprehensive Identification of Phosphorylation Sites on the Numb Endocytic Adaptor Protein
Numb is an endocytic adaptor protein that functions in the endocytosis and intracellular trafficking of membrane receptors and adhesion molecules. Numb localization and function have been shown to be regulated by phosphorylation through atypcial protein kinase C at several key sites. Here, we use ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-04 | MSV000080218 | MassIVE
ProteomicsProteomic analysis of phosphorylation sites in rice panicle grain number-related proteins
The in vitro purified protein was used to detect the phosphorylation sites of substrates by kinases.
ORGANISM(S): Oryza sativa (Rice) 
2025-09-09 | PXD064053 | Pride
Phosphorylation sites ，rice，lc-msms 
ProteomicsIdentification of AMPK phosphorylation sites reveals a network of proteins involved in cell invasion and facilitates large-scale substrate prediction
AMP-activated protein kinase (AMPK) is a central energy gauge that regulates metabolism and has been increasingly involved in non-metabolic processes and diseases. However, AMPK’s direct substrates in non-metabolic contexts are largely unknown. To better understand the AMPK network, we use a chemica...
ORGANISM(S): Homo sapiens (Human) 
2015-10-09 | PXD003019 | Pride
Substrate identification Ampk Phosphorylation Substrate prediction 
TranscriptomicsPhosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function
Mutations of MECP2 (Methyl-CpG Binding Protein 2) cause Rett Syndrome. As a chromatin associated multifunctional protein, how MeCP2 integrates external signals and regulates neuronal function remain unclear. While neuronal activity-induced phosphorylation of MeCP2 at serine 421 (S421) has been repor...
ORGANISM(S): Mus musculus 
2009-02-10 | E-GEOD-14715 | biostudies-arrayexpress
ProteomicsConfirmation of the phosphorylation sites of human PhK
The activity of PhK is regulated by phosphorylation, and we utilized single-particle cryo-electron microscopy to solve the high-resolution structures of human PhK under phosphorylation and calcium ion activation. To gain a deeper insight into the phosphorylation sites following PKA treatment, we emp...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD059345 | Pride
Phosphorylation sites，phk 
ProteomicsThe identification of phosphorylation sites of IBTK by shotgun proteomics
Translation is a tightly regulated process, and the mTORC1-S6K signaling axis plays a critical role in this control. Binding of eIF4F to the cap is hindered by eIF4E binding proteins (4EBPs), which, when hypophosphorylated, sequester eIF4E and prevent its association with eIF4G. However, in response...
ORGANISM(S): Homo sapiens (Human) 
2024-05-10 | PXD038307 | Pride
Ibtk Phosphorylation Shotgun 
ProteomicsIdentification of the Kinase phosphorylation sites on AtGPA1 in presence of GDP
Phosphorylation of GPA1 has been shown to functionally important in vitro and in vivo. We previously identified18 LRR RLKs transphosphorylation of AtGPA1 via in vitro kinase assay using recombinant kinase domains and AtGPA1 (Bo et al., 2018, J. Biol. Chem 293(13): 4752-4766). Among them, we here cho...
ORGANISM(S): Arabidopsis Thaliana (ncbitaxon:3702) 
2019-06-12 | MSV000083963 | MassIVE
ProteomicsRegulation of Glycogen Synthase kinase 3beta by phosphorylation and O-beta-linked N-acetylglucosaminylation: implications on tau protein phosphorylation
Glycogen synthase kinase 3 (GSK3) plays a pivotal role in signaling pathways related to insulin metabolism and in the pathogenesis of Alzheimer s disease (AD) and other neurodegenerative disorders. More particularly, the GSK3beta isoform is involved in AD-associated tau pathology as one of the major...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-02-09 | MSV000094049 | MassIVE
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