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ProteomicsProteomic analysis of extracellular vesicles derived from platelet concentrates treated with Mirasol® identifies biomarkers of platelet storage lesion
In blood banks, platelets are stored until 7 days after a pathogen reduction technology (PRT) treatment, Mirasol® (vitamin B2 plus UVB light) in the present case. The storage time under these conditions may have an impact on platelets and their releasate leading to potential adverse reactions follow...
ORGANISM(S): Homo sapiens (Human) 
2022-09-30 | PXD014694 | Pride
Extracellular vesicles  platelet concentrates  transfusion medicine  swath 
ProteomicsA Comprehensive Proteomics Study on Platelet Concentrates: Platelet Proteome, Storage Time and Mirasol Pathogen Reduction Technology
Platelet concentrates (PCs) represent a blood transfusion product with a major concern for safety as their storage temperature (20-24ºC) allows bacterial growth, and their maximum storage time period (less than a week) precludes complete microbiological testing. Pathogen inactivation technologies (P...
ORGANISM(S): Homo sapiens (Human) 
2018-03-23 | PXD008119 | Pride
Platelet function tests Storage time Platelet transfusion Pathogen inactivation technologies Blood safety Proteomics 
ProteomicsPlatelet proteomics profiling in transfusion adverse events
Blood platelets destined for transfusion release panoply of molecules during preparation and storage. The leukoreduction process made the transfusion safer but did not completely abolish the adverse events. The rationale is to study the proteome profile of platelet components SDA-PC (platelet pellet...
ORGANISM(S): Homo sapiens (Human) 
2019-02-13 | PXD008886 | Pride
Platelet concentrates (pc) Proteomics Transfusion Single donor apheresis-pc (sda-pc) 
ProteomicsPlatelet proteomics profiling in transfusion adverse events, part 2
Blood platelets destined for transfusion release panoply of molecules during preparation and storage. The leukoreduction process made the transfusion safer but did not completely abolish the adverse events. The rationale is to study the proteome profile of platelet components PPC (platelet pellets) ...
ORGANISM(S): Homo sapiens (Human) 
2019-02-13 | PXD003510 | Pride
Platelet concentrates (pc) Proteomics Buffy-coat-derived pooled pc (ppc) Transfusion 
GenomicsComparative transcriptional analysis of Staphylococcus epidermidis biofilm matrix variants in human platelet concentrates
Comparative transcriptional analysis of Staphylococcus epidermidis biofilm matrix variants in human platelet concentrates
PRJNA645929 | ENA
GenomicsPlatelet pathogen reduction technologies alter the microRNA profile of platelet-derived microparticles
Platelet pathogen reduction technologies alter the microRNA profile of platelet-derived microparticles
PRJNA576924 | ENA
ProteomicsLabel free quantitative mass spectrometry identifies platelet degranulation as an early event during platelet storage
Shelf life of platelet concentrates (PCs) is limited to up to 7 days due to loss of platelet functionality during storage, commonly referred to as the platelet storage lesion (PSL). To get more insight into the development of the PSL, we used label free quantitative mass spectrometry to identify cha...
ORGANISM(S): Homo sapiens (Human) 
2017-09-11 | PXD005610 | Pride
Proteomics Label free quantification Alpha-granules Platelet storage Platelets 
ProteomicsDeciphering changes to human platelet proteome and degradome during storage before transfusion
Proteases, and specifically metalloproteinases, have been linked to the loss of platelet function during storage before transfusion, albeit the mechanism remains unknown. We used a dedicated N-terminomics technique, multiplex iTRAQ-TAILS (Terminal Amine Isotope Labeling of Substrates), to characteri...
ORGANISM(S): Homo sapiens (Human) 
2014-10-24 | PXD000906 | Pride
Platelets Metalloproteinases Degradome Proteases Tails Human Ls-msms 
GenomicsPlatelet pathogen reduction technologies alter the microRNA profile of platelet-derived microparticles
The aim of this project was to elucidate the microRNA profile of platelets and of platelet-derived microparticles isolated from clinical platelet concentrates treated or not with pathogen reduction technologies.
ORGANISM(S): Homo sapiens 
2020-04-09 | GSE138735 | GEO
UnknownEnhanced oxygen availability and preserved aggregative function in platelet concentrates stored at reduced platelet concentration.
Not available
S-EPMC11925141 | biostudies-literature
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