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TranscriptomicsDistinct structural transitions of chromatin topological domains coordinate hormone-induced gene regulation
The three-dimensional (3D) organization of the genome within the cell nucleus contributes to cell-specific gene expression in different cell types1. High-throughput 3CM-bM-^@M-^Sderived methods have revealed that the genome is segmented into contiguous topologically associating domains (TADs), which...
ORGANISM(S): Homo sapiens 
2014-10-06 | E-GEOD-53463 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse primary osteoblastic cells after intermittent of continuous treatment with parathyroid hormone to investigate the role of beta-arrestin2
Role of beta-arrestin2 in response to intermittent or continuous parathyroid hormone (PTH) treatment.
ORGANISM(S): Mus musculus 
2009-07-20 | E-TABM-624 | biostudies-arrayexpress
TranscriptomicsInhibitory Actions of Anti-MM-CM-
The current study was designed to investigate the actions of Anti-MM-CM-
ORGANISM(S): Rattus norvegicus 
2011-03-04 | E-GEOD-25629 | biostudies-arrayexpress
TranscriptomicsIsoform-specific transcriptional activity of overlapping targets that respond to thyroid hormone receptors a1 and b1
Thyroid hormone receptors (TRs) are hormone-regulated transcription factors that control multiple aspects of physiology and development. TRs are expressed in vertebrates as a series of distinct isoforms that exert distinct biological roles. We wished to determine if the two most widely expressed i...
ORGANISM(S): Homo sapiens 
2009-08-08 | E-GEOD-17561 | biostudies-arrayexpress
MetabolomicsIAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function
The islet in type 2 diabetes (T2D) is characterized by amyloid deposits derived from islet amyloid polypeptide (IAPP), a protein co-expressed with insulin by β-cells. In common with amyloidogenic proteins implicated in neurodegeneration, human IAPP (hIAPP) forms membrane permeant toxic oligomers imp...
2020-04-17 | MTBLS951 | MetaboLights
TranscriptomicsTranscription profiling of mouse soleus muscle from hormone sensitive lipase-null animals
Expression analysis in order to elucidatethe role of hormone-sensitive lipase in soleus muscle.
ORGANISM(S): Mus musculus 
2008-06-11 | E-GEOD-1772 | biostudies-arrayexpress
TranscriptomicsJuvenile hormone regulation of Drosophila aging
Background. Juvenile hormone (JH) has been demonstrated to control adult lifespan in a number of non-model insects where surgical removal of the corpora allata eliminates the source of hormone. In contrast, little is known about how juvenile hormone affects adult Drosophila melanogaster. Previous w...
ORGANISM(S): Drosophila melanogaster 
2013-07-26 | E-GEOD-48145 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Drosophila Hr39 mutant females reveals the sf1-related nuclear hormone receptor hr39 regulates Drosophila female reproductive tract development and function
The vertebrate nuclear hormone receptor steroidogenic factor 1 (SF1; NR5A1) controls reproductive development and regulates the transcription of steroid-modifying cytochrome P450 genes. We find that the SF1-related Drosophila nuclear hormone receptor HR39 is also essential for sexual development. In...
ORGANISM(S): Drosophila melanogaster 
2008-06-11 | E-GEOD-10264 | biostudies-arrayexpress
TranscriptomicsGene expression in liver tissue from Ghrh-KO and normal (wild-type) mice
The hypothalamus has recently emerged as a key regulator of metabolism and aging in mammals. We have examined the impact of targeted disruption of hypothalamic hypophysiotropic peptide: Growth Hormone-releasing Hormone (GHRH) in mice on longevity, and the putative mechanisms of delayed aging. GHRH k...
ORGANISM(S): Mus musculus 
2013-11-18 | E-GEOD-51108 | biostudies-arrayexpress
TranscriptomicsSex-specific early growth hormone response genes in rat liver (Rattus norvegicus)
A series of two color gene expression profiles obtained using Agilent 44K expression microarrays was used to examine sex-dependent and growth hormone-dependent differences in gene expression in rat liver. This series is comprised of pools of RNA prepared from untreated male and female rat liver, hy...
ORGANISM(S): Rattus norvegicus 
2008-05-24 | E-GEOD-11529 | biostudies-arrayexpress
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