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ProteomicsOxidation of peroxiredoxin-4 induces oligomerization and promotes interaction with endoplasmic reticulum proteins
The family of peroxiredoxins catalyzes the reduction of hydrogen peroxide (H2O2). Peroxiredoxin 4 (PRDX4) is the only peroxiredoxin located within the endoplasmic reticulum (ER) and is the highest expressed ER H2O2 scavenger. PRDX4 has emerged as an important player in numerous diseases and its over...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-10 | PXD024687 | Pride
Prdx4 Tert-butyl hydroperoxide 
ProteomicsProteomic analysis of HEK293T cells deficient in PRDX4 protein
To elucidate the regulatory network of PRDX4, we identified its interacting proteins through large-scale immunoprecipitation coupled with MS-based proteomics analysis. Notably, among the identified proteins, a E3 ubiquitin ligase ARIH1 potentially involved in PRDX4 degradation was enriched, with exh...
ORGANISM(S): Homo sapiens (Human) 
2026-01-29 | PXD073759 | Pride
Human  e3 ubiquitin ligases  prdx4  proteomics  ubiquitination 
GenomicsNOX4 links metabolic regulation in pancreatic cancer to endoplasmic reticulum redox vulnerability and dependence on PRDX4
NOX4 links metabolic regulation in pancreatic cancer to endoplasmic reticulum redox vulnerability and dependence on PRDX4
PRJNA699511 | ENA
TranscriptomicsNOX4 links metabolic regulation in pancreatic cancer to endoplasmic reticulum redox vulnerability and dependence on PRDX4
PDAC cells acquire metabolic changes that augment NADPH production and cytosolic redox homeostasis. Here we show that high NADPH levels drive activity of NADPH oxidase 4 (NOX4) expressed in the endoplasmic reticulum (ER) membrane. NOX4 produces H2O2 metabolized by Peroxiredoxin 4 (PRDX4) in the ER l...
ORGANISM(S): Homo sapiens 
2021-05-25 | GSE166165 | GEO
UnknownPRDX4 overexpression is associated with poor prognosis in gastric cancer.
Not available
S-EPMC7114939 | biostudies-literature
UnknownProtective Effects of Peroxiredoxin 4 (PRDX4) on Cholestatic Liver Injury.
Not available
S-EPMC6163182 | biostudies-literature
UnknownValidation of the interaction between PRDX4 and TXNDC5 in gastric cancer and the significance of the PRDX4 gene in gastric cancer based on a data mining analysis.
Not available
S-EPMC10894329 | biostudies-literature
ProteomicsARIH1 mediates PRDX4 ubiquitination
To determine the ubiquitinated sites on PRDX4, we analyzed ubiquitinated PRDX4 via MS, revealing modifications at six lysine residues. Point mutation analysis confirmed that K265 residue is the primary site for ARIH1-mediated PRDX4 ubiquitination. The K265 mutation (K265R) almost abolished PRDX4 ubi...
ORGANISM(S): Homo Sapiens 
2026-01-29 | PXD073745 |
UnknownImmune infiltration related PRDX4 facilitates the malignant features and drug resistance of breast cancer.
Not available
S-EPMC12304276 | biostudies-literature
UnknownERO1-independent production of H2O2 within the endoplasmic reticulum fuels Prdx4-mediated oxidative protein folding.
Not available
S-EPMC4621842 | biostudies-literature
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