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GenomicsOptimization of the TeraTox assay for preclinical teratogenicity assessment
Optimization of the TeraTox assay for preclinical teratogenicity assessment
PRJNA761146 | ENA
TranscriptomicsSGEV_LRS
Comparison of genomic expression profiles in the mesenteric lymph nodes of naturally scrapie infected (clinical and preclinical stages) and control sheep. Expression profiles comparison of 7 clinical and 4 preclinical naturally scrapie infected sheep and 6 controls.
ORGANISM(S): Ovis aries 
2013-10-29 | E-MTAB-1346 | biostudies-arrayexpress
TranscriptomicsCross-species gene expression analysis of species-specific differences in preclinical assessment of pharmaceutical compounds (rat)
Significant qualitative and quantitative differences exist between humans and the animal models used in research. However, significant quantitative and qualitative differences exist between humans and the animal models used in research. This is as a result of genetic variation between human and the ...
ORGANISM(S): Rattus norvegicus 
2014-04-30 | E-GEOD-47695 | biostudies-arrayexpress
TranscriptomicsCross-species gene expression analysis of species-specific differences in preclinical assessment of pharmaceutical compounds (human)
Significant qualitative and quantitative differences exist between humans and the animal models used in research. However, significant quantitative and qualitative differences exist between humans and the animal models used in research. This is as a result of genetic variation between human and the ...
ORGANISM(S): Homo sapiens 
2014-04-30 | E-GEOD-47970 | biostudies-arrayexpress
TranscriptomicsSPGEV
Comparison of genomic expression profiles in the medulla oblongata of 4 preclinical naturally scrapie infected sheep and 6 controls.. The experiment consisted of the comparison of gene expression profiles in the medulla oblongata of preclinical scrapie and control sheep using oligoDNA CVI-Agilent c...
ORGANISM(S): Ovis aries 
2012-11-14 | E-MTAB-866 | biostudies-arrayexpress
ProteomicsIntroducing the Sinclair Nanopig™ model: Preliminary genomic, proteomic, and hepatic CYP450 characterization for (bio)pharmaceutical safety assessment
he Nanopig™ model is an emerging non-rodent platform for (bio)pharmaceutical safety assessment, with potential advantages for translational research. Here, we report initial characterization results using whole genome sequencing (WGS) and tissue-based proteomics, focusing on drug metabolism and immu...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2025-10-08 | PXD068793 | Pride
Hepatic cyp450 Preclinical model Nanopig Whole genome sequencing Proteomics 
TranscriptomicsOptimization of the TeraTox assay for preclinical teratogenicity assessment
Stem-cell-based in vitro systems are promising tools to predict human teratogenicity. However, current in vitro assays are limited because they either capture effects on a certain germ layer or focus on a subset of predictive markers. Here we report the characterization and critical assessment of Te...
ORGANISM(S): Homo sapiens 
2022-05-03 | GSE183534 | GEO
ProteomicsFlycodes enable preclinical analysis of dozens of antibodies using single cassette-dosed mice. Dataset 6/6
During discovery and development of protein-based drugs, extensive animal testing is required for preclinical analysis of pharmacokinetics, tissue biodistribution, toxicity, etc. Generally, several animals are required for testing a single drug. We show that the use of genetically encoded peptide ba...
ORGANISM(S): Mus musculus (Mouse) synthetic construct 
2025-02-26 | PXD036668 | Pride
Drug development Antibodies Peptide barcodes Cassette dosing 
ProteomicsFlycodes enable preclinical analysis of dozens of antibodies using single cassette-dosed mice. Dataset 3/6
During discovery and development of protein-based drugs, extensive animal testing is required for preclinical analysis of pharmacokinetics, tissue biodistribution, toxicity, etc. Generally, several animals are required for testing a single drug. We show that the use of genetically encoded peptide ba...
ORGANISM(S): Homo sapiens (Human) 
2025-02-26 | PXD036661 | Pride
Drug development Antibodies Peptide barcodes Cassette dosing 
ProteomicsFlycodes enable preclinical analysis of dozens of antibodies using single cassette-dosed mice. Dataset 1/6
During discovery and development of protein-based drugs, extensive animal testing is required for preclinical analysis of pharmacokinetics, tissue biodistribution, toxicity, etc. Generally, several animals are required for testing a single drug. We show that the use of genetically encoded peptide ba...
ORGANISM(S): Homo sapiens (Human) 
2025-02-26 | PXD036658 | Pride
Drug development Antibodies Peptide barcodes Cassette dosing 
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