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ProteomicsKinase activity of DYRK family members is required for regulating primary cilium length, stability and morphology
The dual-specificity tyrosine-phoshorylation-regulated kinase (DYRK) family are multifunctional enzymes crucial for diverse cellular processes, including signaling through the primary cilium. Their dysregulation has been implicated in various cancers and developmental disorders, highlighting the nee...
ORGANISM(S): Homo sapiens (Human) 
2025-06-10 | PXD064683 | Pride
Dyrk3 Primary cilium Bioid 
ProteomicsGlucagon secretion requires IDE cilium axis
Hyglucagonemia is a hallmark of diabetes caused by dysregulation of glucagon secretion by pancreatic alpha-cells. Although glucose sensing and insulin signaling are well-established regulators, the pathways governing glucagon secretion are not fully understood. Recent evidences suggest that insulin-...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-23 | PXD065342 | Pride
Insulin-degrading enzyme-primary cilium axis Glucagon 
ProteomicsTMT analysis of flagellum skeletons from MIP knockdown parasites
TMT data associated with Shimogawa et al. 'FAP106 is an interaction hub required for stable assembly of conserved and lineage-specific proteins at the cilium inner junction'
ORGANISM(S): Trypanosoma Brucei (ncbitaxon:5691) 
2022-11-07 | MSV000090661 | MassIVE
ProteomicsAPEX2 proximity proteomics of microtubule inner proteins FAP45 and FAP52
APEX2-based proximity proteomics data associated with Shimogawa et al. 'FAP106 is an interaction hub required for stable assembly of conserved and lineage-specific proteins at the cilium inner junction'
ORGANISM(S): Trypanosoma Brucei (ncbitaxon:5691) 
2022-11-07 | MSV000090660 | MassIVE
GenomicsEZH2-mediated primary cilium deconstruction drives metastatic melanoma formation
EZH2-mediated primary cilium deconstruction drives metastatic melanoma formation
PRJNA448706 | ENA
TranscriptomicsNew insights into the molecular actions of Grosheimin, Costunolide, α- and β- Cyclocostunolide on primary cilia structure and Hedgehog signaling
Human retinal pigment epithelial (RPE) cells were treated with the sesquiterpene lactones α-cyclocostunolide (α-C) or Grosheimin to investigate their effects on primary cilium structure and associated signaling pathways. Sesquiterpene lactones (SLs) are plant-derived metabolites known for diverse ph...
ORGANISM(S): Homo sapiens 
2025-11-20 | E-MTAB-15939 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of C. elegans DAF-19 uncovers a ciliary base-associated protein and a CDK/CCRK/LF2p-related kinase required for intraflagellar transport.
Cilia are ubiquitous cell surface projections that modulate various sensory- and motility based processes and are implicated in a growing number of multi-organ genetic disorders termed ciliopathies. As new components required for cilium biogenesis and function remain unidentified, we sought to furth...
ORGANISM(S): Caenorhabditis elegans 
2011-07-25 | E-GEOD-25633 | biostudies-arrayexpress
GenomicsThe Neuronal Primary Cilium is a Key Regulator of Homeostatic Plasticity
The Neuronal Primary Cilium is a Key Regulator of Homeostatic Plasticity
PRJNA1314168 | ENA
TranscriptomicsPrimary cilium-autophagy-Nrf2 (PAN) axis links the cell cycle to neuroectoderm fate in human embryonic stem cells
Under defined differentiation conditions human embryonic stem cells (hESCs) can be directed toward a mesendodermal (ME) or neuroectoderm (NE) fate, the first decision during hESC differentiation. Coupled with G1 lengthening a divergent ciliation pattern emerged within the first 24 hours of induced l...
ORGANISM(S): Homo sapiens 
2016-03-24 | E-GEOD-69982 | biostudies-arrayexpress
UnknownPrimary Cilium-Dependent Signaling Mechanisms.
Not available
S-EPMC5713242 | biostudies-literature
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