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MetabolomicsGlucagon-induced PGC-1aplha4/PPARgamma promotes hepatic lipid storage and macrosteatosis in fasting and MASLD

Please update the study abstract/descriptionThe liver plays a central role in regulating the transition between fasting and feeding states, coordinating glycogen breakdown, gluconeogenesis, fatty acid catabolism, and lipid storage. Disruptions in this balance contribute to metabolic disorders, in...

2026-06-16 | MTBLS13087 | MetaboLights
MetabolomicsAkkermansia muciniphila secretes a glucagon-like peptide-1-inducing protein that improves glucose homeostasis and ameliorates metabolic disease
The gut microbiome is a key factor regulating energy-metabolism, glucose tolerance and the immune system. Akkermansia muciniphila has been identified as being beneficial gut bacterium for metabolic diseases, including obesity and type 2 diabetes (T2D); however, the molecular mechanisms involved in h...
2021-01-13 | MTBLS1824 | MetaboLights
TranscriptomicsRNA-seq of livers from female mice treated for eight weeks with the glucagon analogue, NNC9204-0043, compared to female mice treated with PBS (control group)
Chronic glucagon receptor activation with a long-acting glucagon analogue increases amino acid catabolism, and to dissect the molecular mechanism underlying this effect, RNA sequencing of liver biopsies from female mice treated for eight weeks with GCGA or PBS were performed.
ORGANISM(S): Mus musculus 
2022-10-11 | E-MTAB-12040 | biostudies-arrayexpress
Proteomics13C15N – Glucagon-based novel isotope dilution mass spectrometry method for measurement of glucagon metabolism in humans
Glucagon serves as an important regulatory hormone for regulating blood glucose concentrations with tight feedback control with insulin and glucose. There are critical gaps in our understanding of glucagon kinetics, pancreatic α cell function and intra-islet feedback network that are disrupted in ty...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD028715 | Pride
Glucagon Prm Stable isotope dilution Lc-ms/ms 
TranscriptomicsRNA-seq of livers from mice treated for eight weeks with the glucagon receptor antibody, REGN1193, compared to mice treated with a control antibody, REGN1945, (control group)
Chronic glucagon receptor inhibition with a glucagon receptor antibody decreases amino acid catabolism and ureagenesis, while increasing plasma triglyceride concentrations, plasma very-low density lipoprotein cholesterol concentrations, and liver triglyceride concentrations. To dissect the molecular...
ORGANISM(S): Mus musculus 
2022-10-09 | E-MTAB-12048 | biostudies-arrayexpress
TranscriptomicsRNA-seq of livers from glucagon receptor knock-out (GcgrKO) mice compared to wildtype littermates
Glucagon is a key regulator of glucose homeostasis, amino acid catabolism, and lipid metabolism. Glucagon receptor knock-out (GcgrKO) mice have slightly reduced blood glucose levels whereas plasma levels of amino acids are vastly increased reflecting disruption of hepatic amino acid catabolism. To d...
ORGANISM(S): Mus musculus 
2022-10-11 | E-MTAB-12060 | biostudies-arrayexpress
MetabolomicsA Metabolomic Signature of Glucagon Action in Healthy Individuals with Overweight/Obesity Humans
Not available
ORGANISM(S): Homo sapiens 
ST001515 | MetabolomicsWorkbench
TranscriptomicsEffects of KAT2B and WDR5 depletion on hepatocyte gene expression
During fasting, increases in circulating pancreatic glucagon maintain glucose balance by up-regulating hepatic gluconeogenesis. Triggering of the cAMP pathway stimulates the gluconeogenic program through the phosphorylation of CREB and via the de-phosphorylation of the CREB coactivator CRTC2. Hormon...
ORGANISM(S): Mus musculus 
2014-04-21 | E-GEOD-47179 | biostudies-arrayexpress
ProteomicsA glucagon variant, glucagon 1-61, identified in man, controls blood glucose through regulation of insulin secretion and hepatic glucose production
Glucagon is secreted from pancreatic α-cells, and hypersecretion (hyperglucagonemia) contributes to diabetic hyperglycemia. Molecular heterogeneity in hyperglucagonemia is poorly investigated. By screening human plasma by high-resolution-proteomics, we identified several glucagon variants among whic...
ORGANISM(S): Homo sapiens (Human) 
2017-10-20 | PXD005677 | Pride
Glucagon Diabetes 
TranscriptomicsRNA-seq of kidneys from mice treated for eight weeks with the glucagon analogue, NNC9204-0043, compared to mice treated with PBS
Chronic glucagon receptor activation induced by a long-acting glucagon analogue causes thickening of the parietal layer of Bowman’s capsule, causes mesangial area expansion, and formation of albuminuria. To dissect the molecular mechanism underlying these effects, RNA sequencing of kidney biopsies f...
ORGANISM(S): Mus musculus 
2023-12-01 | E-MTAB-12520 | biostudies-arrayexpress
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