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TranscriptomicsShort RNAs expression profiling in circulating CD34+ cells from Primary Myelofibrosis patients and from normal controls pooled bone marrow CD34+ cells.
We report the application of Illumina short RNA sequencing for characterization and discovery of miRNAs and moRNAs, and for identification of differentially expressed small RNAs in circulating CD34+ cells from Primary Myelofibrosis (PMF) patients and from normal controls pooled bone marrow CD34+ cel...
ORGANISM(S): Homo sapiens 
2016-03-17 | E-GEOD-69089 | biostudies-arrayexpress
TranscriptomicsIntegrative Analysis of Gene and miRNA expression profiles in Primary Myelofibrosis CD34+ cells
Ph-negative myeloproliferative neoplasms (MPNs) are characterized by many somatic mutations which have already been shown useful in the prognostic assessment of MPN patients. Moreover, aberrant microRNA (miRNA) expression seems to add to the molecular complexity of MPNs, as specific miRNA signatures...
ORGANISM(S): Homo sapiens 
2014-10-01 | E-GEOD-53482 | biostudies-arrayexpress
TranscriptomicsRNA-seq of JAK2VF and DNMT3A mutant Myelofibrosis patients
Determination of differentially expressed genes from peripheral blood of Myelofibrosis patients with JAK2VF and JAK2VF and DNMT3A mutations
ORGANISM(S): Homo sapiens 
2018-12-01 | E-MTAB-7255 | biostudies-arrayexpress
ProteomicsGlycoproteoforms of Integrins α2 and β1 in Megakaryocytes in the Occurrence of Primary Myelofibrosis
Primary myelofibrosis (PMF) is a myeloproliferative neoplasm prone to leukemic transformation, for which limited treatment is available. Amongst individuals diagnosed with PMF, the most prevalent mutation is the JAK2V617F somatic point mutation that activates the Janus kinase 2 (JAK2) enzyme. Our ea...
ORGANISM(S): Mesocricetus auratus (Golden hamster) Mus musculus (Mouse) 
2022-02-22 | PXD030550 | Pride
Integrins  megakaryocytes  primary myelofibrosis  lc-ms/ms  glycopeptiforms 
TranscriptomicsGene expression profile of mutated and wild-type PMF CD34+ cells
Primary mielofibrosis (PMF) is a rare chronic myeloproliferative disorder characterized by the accumulation of abnormal megakaryocytes (Mks) in the bone marrow (BM), variable degrees of BM fibrosis, osteosclerosis and angiogenesis, immature myeloid and erythroid cells, and tear-drop erythrocytes in ...
ORGANISM(S): Homo sapiens 
2013-07-23 | E-GEOD-41812 | biostudies-arrayexpress
TranscriptomicsBone marrow transplantation outcomes in primary myelofibrosis
Patient samples were analysed for the presence of genomic aberrations prior to ABMT and following relapse, in case it occurred, in patients with primary myelofibrosis.
ORGANISM(S): Homo sapiens 
2020-11-29 | E-MTAB-9110 | biostudies-arrayexpress
TranscriptomicsTranscriptome Study of CD34+ hematopoietic progenitor from patients reached of Primary Myelofibrosis
An increased number of circulating CD34+ hematopoietic progenitors (HP) and a prominent amplification of dystrophic megakaryocytes (MK) are observed in PMF patients. As transcriptome data from CD34+ hematopoietic progenitors showed modulations of FLT3 and MAP kinase expression independently of the...
ORGANISM(S): Homo sapiens 
2008-07-29 | E-GEOD-12234 | biostudies-arrayexpress
TranscriptomicsIdentification of potential new therapeutic approaches for JAK2 V617F mutant patients
Myelofibrosis is often associated with the myeloproliferative neoplasms and expression of oncogenic JAK2 mutants. Patients with myelofibrosis have diminished quality of life due to systemic symptoms arising from fibrotic changes in the bone marrow. The introduction of the JAK2 inhibitor, ruxolitinib...
ORGANISM(S): Homo sapiens 
2022-08-11 | E-MTAB-11653 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of bone marrow mesenchymal stromal cells from patients with Primary Myelofibrosis
Primary myelofibrosis (PMF) is a clonal myeloproliferative neoplasm whose severity and treatment complexity is attributed to the presence of bone marrow (BM) fibrosis and alterations of stroma impairing the production of normal blood cells. Despite the recently discovered mutations including the JA...
ORGANISM(S): Homo sapiens 
2015-01-10 | E-GEOD-44426 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of in vitro MSC-derived osteoblastic cells from patients with Primary Myelofibrosis
Primary myelofibrosis (PMF) is a clonal myeloproliferative neoplasm whose severity and treatment complexity is attributed to the presence of bone marrow (BM) fibrosis and alterations of stroma impairing the production of normal blood cells. Despite the recently discovered mutations including the JA...
ORGANISM(S): Homo sapiens 
2015-01-10 | E-GEOD-46021 | biostudies-arrayexpress
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