Sort   by:  
 Page size 
ProteomicsGlycoproteoforms of Integrins α2 and β1 in Megakaryocytes in the Occurrence of Primary Myelofibrosis
Primary myelofibrosis (PMF) is a myeloproliferative neoplasm prone to leukemic transformation, for which limited treatment is available. Amongst individuals diagnosed with PMF, the most prevalent mutation is the JAK2V617F somatic point mutation that activates the Janus kinase 2 (JAK2) enzyme. Our ea...
ORGANISM(S): Mesocricetus auratus (Golden hamster) Mus musculus (Mouse) 
2022-02-22 | PXD030550 | Pride
Integrins  megakaryocytes  primary myelofibrosis  lc-ms/ms  glycopeptiforms 
TranscriptomicsThe role of integrins in human cytomegalovirus (HCMV)-infected monocytes.
We have established that human cytomegalovirus (HCMV) infection modulates the biology of target primary blood monocytes, allowing HCMV to use monocytes as 'vehicles' for its systemic spread. HCMV infection of monocytes results in rapid induction of PI(3)K and NF-kB activity. Integrins, which are u...
ORGANISM(S): Homo sapiens 
2010-10-31 | E-GEOD-24238 | biostudies-arrayexpress
GenomicsThe role of b2-integrins for the effector functions of polymorphonuclear granulocytes
The role of b2-integrins for the effector functions of polymorphonuclear granulocytes
PRJNA800683 | ENA
ProteomicsThe USP12/46 deubiquitinases protect integrins from ESCRT-mediated lysosomal degradation
The functions of integrins are tightly regulated via multiple mechanisms including trafficking and degradation. Integrins are repeatedly internalized, routed into the endosomal system and either degraded by the lysosome or recycled back to the plasma membrane. The ubiquitin system dictates whether i...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-06 | PXD054760 | Pride
Ubiquitination Usp12/usp46 Escrt Integrin Dub 
GenomicsSpatial heterogeneity of integrins and their ligands in primary breast tumors
Spatial heterogeneity of integrins and their ligands in primary breast tumors
PRJNA1013084 | ENA
TranscriptomicsTumor exosome integrins determine organotropic metastasis
Stephen Paget first proposed, in 1889, that organ distribution of metastases is a non-random event, yet metastatic organotropism remains one of the greatest mysteries in cancer biology. Here, we demonstrate that exosomes released by lung-, liver- and brain-tropic tumor cells fuse preferentially with...
ORGANISM(S): Homo sapiens 
2015-06-17 | E-GEOD-68919 | biostudies-arrayexpress
TranscriptomicsTumor exosome integrins determine organotropic metastasis
Stephen Paget first proposed, in 1889, that organ distribution of metastases is a non-random event, yet metastatic organotropism remains one of the greatest mysteries in cancer biology. Here, we demonstrate that exosomes released by lung-, liver- and brain-tropic tumor cells fuse preferentially with...
ORGANISM(S): Homo sapiens 
2015-06-17 | GSE68919 | GEO
UnknownThe integrins.
Not available
S-EPMC1929136 | biostudies-literature
UnknownIntegrins.
Not available
S-EPMC2784866 | biostudies-literature
GenomicsLaminin-binding integrins are essential for the maintenance of functional secretory epithelium in lactation
Laminin-binding integrins are essential for the maintenance of functional secretory epithelium in lactation
PRJNA547508 | ENA
Sort   by:  
 Page size