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MetabolomicsLKB1 inactivation elicits a NNMT-mediated methyl sink and confers dependence on PRMT5 in lung cancer
The protein arginine methyl transferase 5 (PRMT5) emerges as a therapeutic target in S-methyl-5'-thioadenosine phosphorylase (MTAP)-deleted cancers, where MTA accumulation partially inhibits its activity. However, It remains unclear whether other genetic alterations can dictate PRMT5 activity in can...
2026-04-30 | MTBLS14411 | MetaboLights
GenomicsPRMT5 genomic deregulation supports growth and stress tolerance in chronic lymphocytic leukemia
Patients suffering from chronic lymphocytic leukemia (CLL) display highly diverse clinical courses ranging from indolent cases to aggressive disease with genetic and epigenetic features resembling this diversity. Here, we developed a comprehensive approach combining a variety of molecular and clinic...
ORGANISM(S): Homo sapiens 
2020-08-19 | E-MTAB-8203 | biostudies-arrayexpress
TranscriptomicsRegulation of constitutive and alternative splicing by PRMT5 reveals a role for Mdm4 pre-mRNA in sensing defects in the spliceosomal machinery (RNA-Seq)
Protein Arginine MethylTransferase 5 (PRMT5) is known to mediate epigenetic control on chromatin and to functionally regulate components of the splicing machinery. In this study we show that selective deletion of PRMT5 in different organs leads to cell cycle arrest and apoptosis. At the molecular le...
ORGANISM(S): Mus musculus 
2013-09-13 | E-GEOD-45284 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of the prmt5 and prmt4a;4b mutant transcriptomes
The goal of this study was to compare the transcriptional profile (RNA-seq) of prmt5 and prmt4a;4b Arabidopsis mutants with their respective wild type plants grown under continous light conditions WT, prmt5 and prmt4a;4b mutant plants were grown together with their respective wild type plants for tw...
ORGANISM(S): Arabidopsis thaliana 
2015-04-03 | E-GEOD-62024 | biostudies-arrayexpress
ProteomicsProtein arginine methyltransferase 5 (PRMT5) is an actionable therapeutic target in CDK4/6 inhibitor-resistant ER+/RB-deficient breast cancer
PRMT5 Co-IP mass spectrometry: Lysates of MCF-7 RB1-knockout cells were pulled down with a PRMT5 antibody or IgG control. The pulldowns were subjected to mass spectrometry analysis. QEX2_981005, QEX2_981006, QEX2_981007: DMSO, IgG QEX2_981008, QEX2_981009, QEX2_981010: DMSO, PRMT5 antibody QEX2_9810...
ORGANISM(S): Homo sapiens (Human) 
2024-01-12 | PXD046996 | Pride
Rb Cdk4/6 inhibitor Prmt5 Breast cancer Estrogen receptor Sdma 
TranscriptomicsPRMT5 protects genomic integrity during global DNA demethylation in primordial germ cells and preimplantation embryos
Primordial germ cells (PGCs) and preimplantation embryos undergo epigenetic reprogramming, which entails comprehensive erasure of DNA methylation. We found that PRMT5, an arginine methyltransferase, translocates from the cytoplasm to the nucleus during this process. Here we show that conditional los...
ORGANISM(S): Mus musculus 
2014-11-14 | E-GEOD-60875 | biostudies-arrayexpress
ProteomicsPRMT5 methyl proteomics in MiaPaca2 cells
Goal: To determine total PRMT5 methyl substrates and those that function through the novel substrate adaptor binding site
ORGANISM(S): Homo sapiens (Human) 
2022-06-13 | PXD019991 | Pride
Prmt5 Arginine methylation Lc-msms 
ProteomicsPRMT5-interacting proteins detected in Hey cells LC–MS
Our previous results indicated that PRMT5 is involved in CDDP resistance and may be regulated by phosphorylation modification. To further explore the mechanism of PRMT5 involved in CDDP resistance, PRMT5-interacting proteins were screened for potential PRMT5 kinases by mass spectrometry.
ORGANISM(S): Homo sapiens (Human) 
2025-03-06 | PXD061397 | Pride
Prmt5 interacting proteins 
TranscriptomicsRegulation of the core pre-mRNA splicing machinery by MYC and PRMT5 is essential to sustain lymphomagenesis [B-cells]
Over-expressed MYC binds to virtually all active promoters within a cell, although with different binding affinities, and modulates gene expression, both positively and negatively. Here, we show that during lymphomagenesis in Eµ-myc transgenic mice, MYC directly up-regulates the transcription of the...
ORGANISM(S): Mus musculus 
2015-05-19 | E-GEOD-60188 | biostudies-arrayexpress
ProteomicsIdentification of PRMT5 phosphorylation sites in Hey cells LC-MS
Previous studies have shown that PRMT5 undergoes various PTMs, including phosphorylation and arginine methylation. In our investigation of PRMT5's PTMs, we detected elevated phospho-Ser/Thr levels of PRMT5 in CDDP-resistant ovarian cancer cells Hey compared to their parental counterparts by co-imm...
ORGANISM(S): Homo sapiens (Human) 
2025-03-06 | PXD061400 | Pride
Prmt5 phosphorylation sites 
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