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ProteomicsSpecific sDMA Modifications on the RGG/RG Motif of METTL14 Regulate Its Function in AML
Protein arginine methylations are crucial post-translational modifications (PTMs) in eukaryotes, playing a significant regulatory role in diverse biological processes. Different forms of arginine methylations are known to co-exist within densely modified arginine-rich protein regions. However, pinpo...
ORGANISM(S): Homo Sapiens 
PXD054570 |
ProteomicsProtein arginine methyltransferase 5 (PRMT5) is an actionable therapeutic target in CDK4/6 inhibitor-resistant ER+/RB-deficient breast cancer
PRMT5 Co-IP mass spectrometry: Lysates of MCF-7 RB1-knockout cells were pulled down with a PRMT5 antibody or IgG control. The pulldowns were subjected to mass spectrometry analysis. QEX2_981005, QEX2_981006, QEX2_981007: DMSO, IgG QEX2_981008, QEX2_981009, QEX2_981010: DMSO, PRMT5 antibody QEX2_9810...
ORGANISM(S): Homo sapiens (Human) 
2024-01-12 | PXD046996 | Pride
Rb Cdk4/6 inhibitor Prmt5 Breast cancer Estrogen receptor Sdma 
UnknownComparative performance of IDEXX SDMA Test and the DLD SDMA ELISA for the measurement of SDMA in canine and feline serum.
Not available
S-EPMC6188631 | biostudies-literature
UnknownSDMA attenuates renal tubulointerstitial fibrosis through inhibition of STAT4.
Not available
S-EPMC10186707 | biostudies-literature
UnknownNext-Generation MDMA Analogue SDMA: Pharmacological and Metabolic Insights.
Not available
S-EPMC12715756 | biostudies-literature
UnknownComparison of serum and plasma SDMA measured with point-of-care and reference laboratory analysers: implications for interpretation of SDMA in cats.
Not available
S-EPMC11197123 | biostudies-literature
UnknownTransport of the uremic toxin symmetric dimethylarginine (SDMA) by renal transport proteins.
Not available
S-EPMC12187869 | biostudies-literature
ProteomicsImproved discrimination of asymmetric and symmetric protein arginine dimethylation by optimizing the normalized collision energy in LC-MS proteomics
Here we optimize the HCD Normalized Collision Energy (NCE) in order to generate neutral losses of monomethylamine and dimethylamine which can be lost by symmetric dimethylarginine and asymmetric dimethylarginine, respectively. By testing a range of NCEs across two different methyl enrichment techniq...
ORGANISM(S): Homo sapiens (Human) 
2020-05-27 | PXD017193 | Pride
Arginine Prmt Mass spectrometry Methylation Adma Ptm Hcd Neutral loss Proteomics Sdma Lcms 
UnknownSpecific sDMA modifications on the RGG/RG motif of METTL14 regulate its function in AML.
Not available
S-EPMC11889898 | biostudies-literature
UnknownEXPRESS: Changes in serum symmetric dimethylarginine (SDMA) concentrations after treatment of feline hyperthyroidism with anti-thyroid medications.
Not available
S-EPMC12924991 | biostudies-literature
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