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TranscriptomicsTranscription repressor Bach2 is required for pulmonary surfactant homeostasis and alveolar macrophage function.
Pulmonary alveolar proteinosis (PAP) results from a dysfunction of alveolar macrophages (AMs), chiefly due to disruptions in the signaling of granulocyte macrophage colony-stimulating factor (GM-CSF). We found that mice deficient for the B lymphoid transcription repressor BTB and CNC homology 2 (Bac...
ORGANISM(S): Mus musculus 
2014-01-15 | E-GEOD-54050 | biostudies-arrayexpress
GenomicsThe chromatin remodeling complex PRC2 safeguards cell fate in alveolar epithelial type 2 cells
The chromatin remodeling complex PRC2 safeguards cell fate in alveolar epithelial type 2 cells
PRJNA1441478 | ENA
ProteomicsInsights into Early Recovery from Influenza Pneumonia by Spatial and Temporal Quantification of Putative Lung Regeneration Cells and buy Lung Proteomics
During influenza pneumonia, the alveolar epithelial cells of the lungs are targeted by influenza virus. The distal airway stem cells (DASCs) and proliferating alveolar type II (AT2) cells are reported to be putative lung repair cells. However, their relative spatial and temporal distribution is stil...
ORGANISM(S): Mus musculus (Mouse) 
2020-04-17 | PXD014967 | Pride
Influenza  pneumonia  lung regeneration  stem cells  comparative quantification  p63  krt5  proliferating alveolar type 2 cells  proteomics 
TranscriptomicsTranscription profiling of mouse lung from T1 alpha (-/-) vs. wild type at fetal and term developmental stages
We compared gene expression in T1alpha (-/-) lungs vs wild type at dpc 18.5 when the phenotype is moderate and at term when the phenotype is more severe. Lungs present narrow and irregular alveolar spaces, thicker mesenchyme, reduced number of attenuated type I cells, normal numbers of type II cells...
ORGANISM(S): Mus musculus 
2007-11-22 | E-GEOD-1363 | biostudies-arrayexpress
TranscriptomicsThe chromatin remodeling complex PRC2 safeguards cell fate in alveolar epithelial type 2 cells
Maintenance of the gas exchange surface throughout life and regeneration of the lung after injury requires tight regulation of epithelial cell fate and function. Alveolar epithelial type 2 (AT2) cells serve as the progenitors of the distal epithelium, differentiating into alveolar epithelial type 1 ...
ORGANISM(S): Mus musculus 
2026-03-31 | GSE325698 | GEO
UnknownLung adenocarcinoma originates from retrovirus infection of proliferating type 2 pneumocytes during pulmonary post-natal development or tissue repair.
Not available
S-EPMC3068994 | biostudies-literature
UnknownCharacterization of circRNA-miRNA-mRNA networks regulating oxygen utilization in type II alveolar epithelial cells of Tibetan pigs.
Not available
S-EPMC9532862 | biostudies-literature
TranscriptomicsChronic Intermittent Hypoxia Increases Alveolar Surface Area in Adult Mice
Obstructive sleep apnea (OSA) leads to increased cardiovascular morbidity and mortality, which have been attributed to intermittent hypoxia (IH). The effects of IH on lung structure and function are unknown. We used a mouse model of chronic IH, which mimics the O2 profile in patients with OSA. We ex...
ORGANISM(S): Mus musculus 
2010-12-31 | E-GEOD-21409 | biostudies-arrayexpress
UnknownHyaluronan Directs Alveolar Type II Cell Response to Acute Ozone Exposure in Mice.
Not available
S-EPMC12254692 | biostudies-literature
UnknownHedgehog-responsive PDGFRa(+) fibroblasts maintain a unique pool of alveolar epithelial progenitor cells during alveologenesis.
Not available
S-EPMC9199394 | biostudies-literature
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