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MetabolomicsUPLC-MS-Based Serum Metabolic Profiling Reveals Potential Biomarkers for Predicting Propofol Responsiveness in Females

Although previous studies have shown that certain factors interfere with the sensitivity of propofol, the mechanisms for interindividual variability in response to propofol remain unclear. This study aimed to screen the metabolites to predict patients' sensitivity to propofol and to identify meta...

2021-09-29 | MTBLS2311 | MetaboLights
MetabolomicsUnraveling the Mechanisms of Propofol-Induced Psychological Dependence: A Multi-Omics Approach Linked to Gut Microbiota in Hippocampal Function

Introduction: Drug abuse is becoming a global public health crisis. According to the United Nations, the number of drug users worldwide has increased dramatically over the past decade, with a surge in the number of drug abusers. The problem was exacerbated by the expanding market for illicit drug...

2025-05-12 | MTBLS12337 | MetaboLights
ProteomicsDisturbance of key cellular subproteomes upon propofol treatment is associated with increased permeability of the blood-brain barrier
Background: Propofol is a short-acting anesthetic, which is often used for induction and maintenance of general anesthesia, sedation for mechanically ventilated adults and procedural sedation. Several side effects of propofol are known and a substantial number of patients suffer from post-operative ...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD033856 | Pride
Anesthetics  blood-brain barrier  dna damage response  drug effect  human brain microvascular endothelial cells  metabolic stress  propofol  proteome  quantitative proteomics  reactive oxygen species (ros) 
Genomicshuman iPSC derived cerebral organoids: Propofol treated vs. DMSO control
human iPSC derived cerebral organoids: Propofol treated vs. DMSO control
PRJNA1132263 | ENA
TranscriptomicsTranscription profiling of human atrial tissue from patients undergoing coronary artery bypass graft surgery to determine the effect of anesthesia on gene expression
Anesthetic gases elicit organ protection in patients undergoing coronary artery bypass graft (CABG) surgery. This study aimed at identifying myocardial transcriptional phenotypes and anesthetic-induced changes in gene expression to predict cardiovascular biomarkers and cardiac function after off-pu...
ORGANISM(S): Homo sapiens 
2008-11-22 | E-GEOD-4386 | biostudies-arrayexpress
GenomicsEffects of propofol on human brain organoids at different maturational stages
Effects of propofol on human brain organoids at different maturational stages
PRJNA1250446 | ENA
GenomicsPropofol alters the mRNA profile in the developing mouse hippocampus
Propofol alters the mRNA profile in the developing mouse hippocampus
PRJNA418091 | ENA
TranscriptomicsEffects of Propofol Treatment in Neural Progenitors Derived from Human Induced Pluripotent Stem Cells
Propofol is an intravenous anesthetic that has been widely used in the clinical setting. Besides its anesthetic effects, propofol has been reported to influence the regulation of autonomic system. Controversies exist with regards to whether propofol exposure is safe for pregnant women and young chil...
ORGANISM(S): Homo sapiens 
2017-07-21 | GSE101724 | GEO
Genomicshuman iPSC derived cerebral organoids: Propofol treated vs. DMSO control
LncRNA and mRNA profiling of human iPSC derived cerebral organoids (Propofol treated vs. DMSO control) were determined. LncRNA and mRNA profiling of human iPSC derived cerebral organoids (Propofol treated vs. DMSO control) were determined.
ORGANISM(S): Homo sapiens 
2025-12-30 | GSE271591 | GEO
GenomicsPropofol Differentially Modulates Neurodevelopmental Processes in Region-Specific Human Brain Organoids
Propofol Differentially Modulates Neurodevelopmental Processes in Region-Specific Human Brain Organoids
PRJNA1213116 | ENA
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