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TranscriptomicsValidation of a genomic classifier that predicts metastasis following radical prostatectomy in at risk patient population
Purpose: Patients with locally advanced prostate cancer after radical prostatectomy are candidates for secondary therapy. However, this higher risk population is heterogeneous. Many cases do not metastasize even when conservatively managed. Given the limited specificity of pathological features to p...
ORGANISM(S): Homo sapiens 
2014-11-13 | E-GEOD-62116 | biostudies-arrayexpress
TranscriptomicsA Novel miRNA-Based Predictive Model for Biochemical Failure Following Post-Prostatectomy Salvage Radiation Therapy
Radical prostatectomy remains one of the more widely-used treatment options for men with prostate cancer. However, few molecular biomarkers have been established to predict patients who are at high risk of biochemical failure. To our knowledge, this is the first such report on miRNA profiling in rad...
ORGANISM(S): Homo sapiens 
2015-01-23 | E-GEOD-65061 | biostudies-arrayexpress
TranscriptomicsGoserelin and bicalutamide treatments alter the expression of microRNAs in prostate
30 patients were randomized equally into three groups: no treatment, bicalutamide (antiandrogen) 150 mg daily, and goserelin (GnRH agonist) 3.6 mg every 4 weeks. Following the neoadjuvant treatment for 12 weeks, patients underwent radical prostatectomy. Freshly frozen specimens were collected for ex...
ORGANISM(S): Homo sapiens 
2012-06-01 | E-MEXP-3530 | biostudies-arrayexpress
TranscriptomicsMolecular alterations in prostate carcinomas that associate with in vivo exposure to chemotherapy
Patients with high-risk localized prostate cancer (tumor-node-metastasis ≥ T2b or prostate-specific antigen ≥ 15 ng/mL or Gleason glade ≥ 4+3) were enrolled into a phase II clinical trial of neoadjuvant chemotherapy with docetaxel and mitoxantrone followed by prostatectomy. Pretreatment prostate tis...
ORGANISM(S): Homo sapiens 
2012-08-29 | E-GEOD-40434 | biostudies-arrayexpress
GenomicsWhole transcriptome analysis of prostatic urethra of rats after thulium laser prostatectomy [miRNA]
Whole transcriptome analysis of prostatic urethra of rats after thulium laser prostatectomy [miRNA]
PRJNA862543 | ENA
TranscriptomicsDiscovery and validation of a prostate cancer genomic classifier that predicts early metastasis following radical prostatectomy
Purpose: Clinicopathologic features and biochemical recurrence are sensitive, but not specific, predictors of metastatic disease and lethal prostate cancer. We hypothesize that a genomic expression signature detected in the primary tumor represents true biological potential of aggressive disease an...
ORGANISM(S): Homo sapiens 
2013-07-01 | E-GEOD-46691 | biostudies-arrayexpress
TranscriptomicsData set for "Gene Expression Profiles in Benign Prostate Tissue Reflect Tumor Proximity, Grade, and Molecular subtype
Background: Normal tissue in a tumor-bearing organ shows morphological and molecular differences from normal tissue in a tumor-free organ. One explanation to this is that tumors actively instruct adjacent normal tissues to support growth and invasion. The aim of this study was to examine if changes ...
ORGANISM(S): Homo sapiens 
2026-10-06 | E-MTAB-17721 | biostudies-arrayexpress
TranscriptomicsCirculating microRNAs predict biochemical recurrence in prostate cancer patients
Comparison of circulating miRNA levels in patients who experienced rapid biochemical recurrence or no recurrence following radical prostatectomy qRT-PCR miRNA expression profiling of patient serum
ORGANISM(S): Homo sapiens 
2013-05-22 | E-GEOD-47125 | biostudies-arrayexpress
GenomicsWhole transcriptome analysis of prostatic urethra of rats after thulium laser prostatectomy [mRNA, lncRNA, circRNA]
Whole transcriptome analysis of prostatic urethra of rats after thulium laser prostatectomy [mRNA, lncRNA, circRNA]
PRJNA862544 | ENA
GenomicsMethylation-based immune deconvolution in prostate cancer patients before and after radical prostatectomy
Methylation-based immune deconvolution in prostate cancer patients before and after radical prostatectomy
PRJNA1117971 | ENA
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