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ProteomicsARIH1 Signaling Promotes Anti-tumor Immunity by Targeting PD-L1 for Proteasomal Degradation
We find EGFR inhibitors promote PD-L1 ubiquitination and proteasomal degradation following GSK3α-mediated phosphorylation of Ser279/Ser283.
ORGANISM(S): Homo Sapiens 
2021-03-01 | PXD024452 |
Genomics PARG regulates the proteasomal degradation of TARG1
 PARG regulates the proteasomal degradation of TARG1
PRJNA1367021 | ENA
GenomicsSUMO-chain-regulated proteasomal degradation timing exemplified in DNA replication initiation
SUMO-chain-regulated proteasomal degradation timing exemplified in DNA replication initiation
PRJNA454214 | ENA
ProteomicsPupylation-independent substrate recruitment to proteasomal degradation in mycobacteria
Mycobacteria and other Actinobacteria possess proteasomal degradation pathways in addition to the common bacterial compartmentalizing protease systems. Proteasomal degradation supports survival of these bacteria in adverse environments and conditions. The mycobacterial proteasome interacts with mult...
ORGANISM(S): Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) 
2023-08-04 | PXD039021 | Pride
Heat shock Mycobacteria Quality control Proteasomal degradation 
TranscriptomicsSHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors
Triple Negative Breast cancer accounts for some of the most aggressive types of breast cancer. By interrogating clinical datasets, we found that the activities of p63 and Hypoxia-Inducible-Factors (HIFs), two master regulators of the invasive and metastatic cancer cell phenotype are linked in TNBC ...
ORGANISM(S): Homo sapiens 
2012-07-18 | E-GEOD-33950 | biostudies-arrayexpress
TranscriptomicsThe ER-Associated Degradation Adapter Protein Sel1L Regulates Triglyceride Metabolism via Lipoprotein Lipase
Sel1L is an adaptor protein for the E3 ligase Hrd1 in the endoplasmic reticulum-associated degradation (ERAD), but its physiological role in a cell-type-specific manner remains unclear. Here we show that mice with adipocyte-specific Sel1L deficiency are resistant to diet-induced obesity and exhibit ...
ORGANISM(S): Mus musculus 
2015-05-18 | E-GEOD-56918 | biostudies-arrayexpress
ProteomicsDependence of Synaptic Protein Degradation on Proteasomal Function
Synaptic function crucially depends on uninterrupted synthesis and degradation of synaptic proteins. While much has been learned on synaptic protein synthesis, little is known on the routes by which synaptic proteins are degraded. Here we systematically studied how inhibition of the ubiquitin-protea...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-10-26 | PXD004813 | Pride
Proteomics Synaptic protein Degradation 
UnknownRegulation of Proteasomal Degradation by Modulating Proteasomal Initiation Regions.
Not available
S-EPMC4922138 | biostudies-literature
ProteomicsDependence of Synaptic Protein Degradation on Proteasomal Function -Part2
Synaptic function crucially depends on uninterrupted synthesis and degradation of synaptic proteins. While much has been learned on synaptic protein synthesis, little is known on the routes by which synaptic proteins are degraded. Here we systematically studied how inhibition of the ubiquitin-protea...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-10-26 | PXD004726 | Pride
Proteomics Synaptic protein Degradation 
ProteomicsDependence of Synaptic Protein Degradation on Proteasomal Function -Part3
Synaptic function crucially depends on uninterrupted synthesis and degradation of synaptic proteins. While much has been learned on synaptic protein synthesis, little is known on the routes by which synaptic proteins are degraded. Here we systematically studied how inhibition of the ubiquitin-protea...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-10-26 | PXD004711 | Pride
Proteomics Synaptic protein Degradation 
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