protective ubiquitination

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Mass Spectrometry (17)
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Affinity purification coupled with mass spectrometry proteomics (1)
Data-dependent acquisition (1)

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LTQ Orbitrap Velos (1)
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2022 (9)
2026 (7)
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2024 (5)
2014 (3)
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2016 (1)
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2018 (1)

Metabolite Name

N-(3-bromophenyl)-2-[4-(morpholin-4-ylcarbonyl)-2-oxohydroquinolyl]acetamide (1)
1,2,4-Triazin-5(2H)-one, 6-(1,1-dimethylethyl)-3-(methylthio)- (1)
2-Hydroxy-4-Methoxychalcone (1)
N,N-Diethyl-4-Hydroxybenzamide (1)
P-Toluenesulfonamide (1)
2-(methylethylidene)butanedioic acid (1)
2-(3-(8-hydroxyoctyl)phenoxy)-2-methylpropanoic acid (1)
2-(4-methyl-6-(2-naphthyloxy)pyrimidin-2-ylthio)-1-phenylethan-1-one (1)
PS(18:1/18:0) (1)
2-(4-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1H-pyrazol-5-yl)-4-ethyl-5-methoxyphenol (1)
3,4-dimethyl-9-phenyl-7H-furo[2,3-f]chromen-7-one (1)
12-Hydroxy-6-Epi-Albrassitriol (1)
Ethyl 2-[2-(1,3,7-trimethyl-2,6-dioxo-1,3,7-trihydropurin-8-ylthio)benzimidazo lyl]acetate (1)
[4-(difluoromethoxy)-3-ethoxyphenyl]-N-(1-methylpyrazol-3-yl)carboxamide (1)
2-{4-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)prop-1-enyl]phenoxy}acetamide (1)
Sissotrine (1)
Methyl 2-[(5,6,7-trimethoxy-3-oxohydroisobenzofuran-4-yl)methylthio]benzoate (1)
N-(2-chlorophenyl)-2-[2-oxo-4-(piperidylcarbonyl)hydroquinolyl]acetamide (1)
NA-135 (1)
1,3,6-Trihydroxy-2-(3-methylbut-2-enyl)xanthen-9-one (1)
7-(1,6-dihydroxy-3-methyl-5-(methylethyl)-8-{[(2-methylphenyl)amino]methylene} -7-oxo(2-naphthyl))-3,8-dihydroxy-6-methyl-4-(methylethyl)-1-{[(2-methylphenyl )amino]methylene}naphthalen-2-one (1)
Phenylmethyl 1-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]pyrrolidine-2-carboxylate (1)
7-Benzofurancarboxylic acid, 2,3-dihydro-2-(1-hydroxy-1-methylethyl)-4-methoxy-6-(2-phenylethyl)- (1)
3-ethyl-4-hydroxy-1-benzylhydroquinolin-2-one (1)
Kaurenic acid (1)
(2Z)-2-benzoxazol-2-yl-3-(4-hydroxy-3-methoxyphenyl)-1-(4-methylphenyl)prop-2- en-1-one (1)
2-[4-(N,N-diethylcarbamoyl)-2-oxohydroquinolyl]-N-(2,4-difluorophenyl)acetamid e (1)
Pantothenic acid (Not validated) (1)
2H-benzo[3,4-d]1,3-dioxolen-5-yl-N-(4,5,6,7-tetrahydrobenzothiazol-2-yl)carbox amide (1)
1H-indole-3-carboxamide (1)

First Public Date

2026 (6)
2024 (4)
2025 (2)
2020 (1)

Study type

Transcription profiling by array (2)
RNA-seq of coding RNA (2)

Release Date

2025 (50)
2023 (31)
2024 (28)
2022 (19)
2020 (15)
2021 (11)
2019 (11)
2018 (11)
2014 (10)
2016 (7)
2015 (7)
2010 (6)
2012 (5)
2026 (4)
2017 (4)
2011 (3)
2013 (3)
2007 (1)

Lab affiliation

Department of Biochemistry and Functional Proteomics, Institute of Biology II, Faculty of Biology and Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104 Freiburg im Breisgau, Germany (5)
State Key Laboratory for Innovation and Transformation of Luobing Theory; Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences; Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China (2)
Cell and Chemical Biology Leiden University Medical Center (1)
Center for Addiction Research Department of Pharmacology and Toxicology The University of Texas Medical Branch Galveston, TX 77555 (1)
College of Pharmacy, College of Integrative Medicine, Dalian Medical University (1)
Department of Biochemistry and Functional Proteomics, Institute of Biology II, Faculty of Biology, CIBBS and BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79104 Freiburg im Breisgau, Germany (1)
Dept. of Radiation Oncology, The University of Michigan Medical School, Medical Science Building I, Ann Arbor, MI 48109 (1)
Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany (1)
Organic Mass Spectrometry Laboratory, Department of Chemical Sciences, University of Catania, Via S. Sofia 64, 95123 Catania, Italy (1)
University of Puerto RIco, Medical Sciences Campus, Translational Proteomics Center (1)
VIB-UGent Center for Medical Biotechnology Department of Biochemistry, Ghent University Ghent, Belgium (1)
Wenzhou Medical University (1)

Tags

xref:PubMed:41028522 (2)
xref:PubMed:39366973 (1)

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Mutant EGFR is a preferred SMURF2 substrate of ubiquitination: role in enhanced receptor stability and TKI sensitivity

We previously reported that differential protein degradation of TKI-sensitive [L858R, del(E746-A750)] and resistant (T790M) epidermal growth factor receptor (EGFR) mutants upon erlotinib treatment correlates with drug sensitivity. However, the molecular mechanism remains unclear. We also reported SM...

ORGANISM(S): Homo sapiens (Human)

2020-07-29 | PXD018324 | Pride

Adenovirus-mediated ubiquitination alters protein-RNA binding and aids viral RNA processing.

Not available

S-EPMC7529849 | biostudies-literature

Elevated ubiquitination contributes to protective immunity against severe SARS-CoV-2 infection.

Not available

S-EPMC9708907 | biostudies-literature

Britannilactone 1-O-acetate induced ubiquitination of NLRP3 inflammasome through TRIM31 as a protective mechanism against reflux esophagitis-induced esophageal injury.

Not available

S-EPMC11363507 | biostudies-literature

Ubiquitin E3 ligase MARCH10 targets influenza hemagglutinin for ubiquitination

PRJNA1368610 | ENA

E3 ubiquitin ligase Listerin regulates macrophage cholesterol efflux and atherosclerosis by targeting ABCA1

Atherosclerosis arises from disrupted cholesterol metabolism, notably impaired macrophage cholesterol efflux leading to foam cell formation. Through single-cell and bulk RNA sequencing, we identified Listerin as a regulator of macrophage cholesterol metabolism. Listerin expression increased during a...

ORGANISM(S): Mus musculus (Mouse)

2025-06-11 | PXD064538 | Pride

Ubiquitination modification cholesterol efflux foam cell atherosclerosi

NEDD4L-Mediated Ubiquitination of GPX4 Exacerbates Doxorubicin-Induced Cardiotoxicity.

Not available

S-EPMC12428739 | biostudies-literature

Bortezomib Rescues Ovariectomy-Induced Bone Loss via SMURF-Mediated Ubiquitination Pathway.

Not available

S-EPMC8741347 | biostudies-literature

A protein quality control pathway regulated by linear ubiquitination.

Not available

S-EPMC6484417 | biostudies-literature