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UnknownAmyloid β accelerates age-related proteome-wide protein insolubility.
Not available
S-EPMC11335993 | biostudies-literature
UnknownAmyloid β accelerates age-related proteome-wide protein insolubility.
Not available
S-EPMC10369951 | biostudies-literature
UnknownDiversity in Aβ deposit morphology and secondary proteome insolubility across models of Alzheimer-type amyloidosis.
Not available
S-EPMC7137436 | biostudies-literature
UnknownProteome solubility is differentially reshaped by thermal stress and regulators of ubiquitination.
Not available
S-EPMC12391699 | biostudies-literature
UnknownWidespread remodeling of proteome solubility in response to different protein homeostasis stresses.
Not available
S-EPMC7007570 | biostudies-literature
UnknownChanges in proteome solubility indicate widespread proteostatic disruption in mouse models of neurodegenerative disease.
Not available
S-EPMC6411038 | biostudies-literature
ProteomicsProteome solubility changes under different proteostasis stresses
The accumulation of aberrant protein aggregates in neurodegenerative diseases is associated with a widespread failure of the protein homeostasis system. To investigate whether there is a subproteome that consistently aggregates under stress and define the broader determinants for protein aggregation...
ORGANISM(S): Mus musculus (Mouse) 
2020-01-29 | PXD014420 | Pride
Proteome solubility Proteomics Stress response Proteostasis 
TranscriptomicsAlzheimer’s disease-associated U1 snRNP splicing dysfunction causes neuronal hyperexcitability and cognitive impairment [N40K neuron RNA-seq]
Recent proteome and transcriptome profiling of Alzheimer's disease (AD) brains reveals RNA splicing dysfunction and U1 small nuclear ribonucleoprotein (snRNP) pathology containing U1-70K and its N-terminal 40-KDa fragment (N40K). Here we present a causative role of U1 snRNP dysfunction to neurodegen...
ORGANISM(S): Mus musculus 
2022-08-11 | GSE196872 | GEO
TranscriptomicsAlzheimer’s disease-associated U1 snRNP splicing dysfunction causes neuronal hyperexcitability and cognitive impairment [N40K mice RNA-seq]
Recent proteome and transcriptome profiling of Alzheimer's disease (AD) brains reveals RNA splicing dysfunction and U1 small nuclear ribonucleoprotein (snRNP) pathology containing U1-70K and its N-terminal 40-KDa fragment (N40K). Here we present a causative role of U1 snRNP dysfunction to neurodegen...
ORGANISM(S): Mus musculus 
2022-08-11 | GSE196871 | GEO
Unknown"One-Pot" Sample Processing Method for Proteome-Wide Analysis of Microbial Cells and Spores.
Not available
S-EPMC6174930 | biostudies-literature
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