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ProteomicsQuantitative analysis of redox proteome reveals protein thiol switches regulating fundamental processes in developmental hematopoiesis
Fetal and adult hematopoietic stem and progenitor cells (HSPCs) are characterized by distinct redox homeostasis that may influence their differential cellular behaviour in normal and malignant haematopoiesis. In this work, we have applied a quantitative mass spectrometry-based redox proteomic approa...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD033115 | Pride
Oxidative modifications Oxidative stress Redox proteomics Hydrogen peroxide Human embryonic stem cells 
ProteomicsCys-SH based quantitative redox proteomics of salt induced response in sugar beet monosomic addition line M14
Salt stress is a major abiotic stress that limits plant growth, development and productivity. Studying the molecular mechanisms of salt stress tolerance may help to enhance crop productivity. Sugar beet monosomic addition line M14 exhibits tolerance to salt stress. In this work, the changes in the ...
ORGANISM(S): Beta vulgaris subsp. vulgaris 
2021-12-30 | PXD027550 | Pride
Molecular mechanisms Sugar beet m14 line Salt stress Redox proteomics Iodotmtraq 
UnknownCys-SH based quantitative redox proteomics of salt induced response in sugar beet monosomic addition line M14.
Not available
S-EPMC8523603 | biostudies-literature
ProteomicsRedox proteome analysis identifies reversible oxidized proteins in retinoic acid differentiated SH-SY5Y cells
Retinoic acid stimulated SH-SY5Y cells are a common model system to study the initial phases of neuronal differentiation. Although these processes are associated with redox-sensitive processes, no comprehensive analysis of oxidative modified cysteines, as one of the main targets for reactive oxygen ...
ORGANISM(S): Homo sapiens (Human) 
2020-03-30 | PXD014381 | Pride
Dynamics Neuronal differentiation Redox Redox proteomics 
ProteomicsA quantitative tissue-specific landscape of protein redox regulation during aging
Mammalian tissues engage in specialized physiology that is regulated by post-translational protein modification. A major mode of protein regulation is initiated by reactive oxygen species (ROS) that reversibly modify protein cysteine residues. ROS regulate a myriad of biological processes and ROS ...
ORGANISM(S): Mus musculus (Mouse) 
2020-02-27 | PXD017050 | Pride
Cpt Redox Aging Cysteine proteomics 
ProteomicsQuantitative analysis of redox proteome reveals protein thiol switches regulating fundamental processes in developmental haematopoiesis
Foetal and adult hematopoietic stem and progenitor cells (HSPCs) are characterized by distinct redox homeostasis that may influence their differential cellular behaviour in normal and malignant haematopoiesis. In this work, we have applied a quantitative mass spectrometry-based redox proteomic appro...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-09 | PXD030043 | Pride
Hematopoiesis Leukemia Oxidative modifications Redox proteomics 
ProteomicsRedox Proteome of Skeletal Muscle
Adult and aged mouse gastrocnemius muscle analysed by redox shotgun proteomics, applying a label free quantitative proteomic approach that includes a differential Cysteine labelling step allowing simultaneous identification of up and down regulated proteins between samples and also the identificatio...
ORGANISM(S): Mus musculus (Mouse) 
2014-09-04 | PXD001054 | Pride
Redox Skeletal muscle 
ProteomicsBenchmark for Quantitative Global and Redox Proteomics Analysis by Combining Protein-Aggregation Capture and Data Independent Acquisition
Oxidative damage is critical in various diseases, including cardiovascular and neurological conditions. Thiol redox reactions, acting as oxidative stress sensors, influence protein structure and function. Redox proteomics based on differential alkylation of reduced and oxidized Cys forms using mass ...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2025-09-08 | PXD060030 | Pride
Myocardial tissue Proteomics Dia Redox Ischemia-reperfusion Atrial fibrillation 
ProteomicsProteomics data of plasma and bronchial alveolar lavage fluid collected from Acute respiratory distress syndrome patients
Acute respiratory distress syndrome (ARDS) is a severe and complex critical illness, characterized by its heterogeneous clinical presentation, making accurate clinical definition and effective treatment challenging. We hypothesized that advanced molecular analyses of matched plasma and bronchial alv...
ORGANISM(S): Homo sapiens (Human) 
2026-02-16 | PXD060437 | Pride
Ards Bronchial alveolar lavage fluid Plasma Redox proteomics Global proteomics 
ProteomicsQuantitative thiol reactivity profiling
Cysteine is unique among all protein-coding amino acids owing to its intrinsically high nucleophilicity. The cysteinyl thiol group can be covalently modified by both a broad range of redox mechanisms and various electrophiles derived from exogenous or endogenous sources. Measuring proteomic cysteine...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-07-24 | PXD016048 | Pride
Thiol Redox Chemical proteomics Electrophile 
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