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ProteomicsCoIP-LC-MS/MS of Rad50 in KO Vs. WT L3 CNS
Cell types are fundamental units of metazoans, however their definition remains a long-standing challenge. We here use high throughput assays allowing for unprecedented resolution and systematic analyses. The comparison of the transcriptional landscapes of related and unrelated Drosophila differenti...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2026-04-27 | PXD056082 | Pride
Chromatin  temporal regulation  rad50  cell identity 
TranscriptomicsTranscription profiling of S. cerevisiae mre11, rad50 and spo11 mutants in premeiosis and meiotic prophase
Mre11, together with Rad50 and Xrs2/NBS, plays pivotal roles in homologous recombination, repair of DNA double strand breaks (DSBs), activation of damage-induced checkpoint, and telomere maintenance. Using DNA microarray assays to analyze yeast mutants (mre11delta, rad50delta, and spo11Y135F) defect...
ORGANISM(S): Saccharomyces cerevisiae 
2007-10-23 | E-GEOD-6620 | biostudies-arrayexpress
GenomicsATAC-seq on rad50∆5.1/rad50∆5.1 and w1118 CNS
ATAC-seq on rad50∆5.1/rad50∆5.1 and w1118 CNS
PRJEB102748 | ENA
TranscriptomicsCohesin association to replication sites depends on Rad50 and promotes fork restart
The cohesin complex holds together newly-replicated chromatids and is involved in diverse pathways that preserve genome integrity. We show that in budding yeast, cohesin is transiently recruited to active replication origins and it spreads along DNA as forks progress. When DNA synthesis is impeded, ...
ORGANISM(S): Saccharomyces cerevisiae W303 
2012-10-01 | E-GEOD-39078 | biostudies-arrayexpress
GenomicsRad50 ChIPseq in Drosophila wandering larval central nervous system and in embryos stage 16
Rad50 is overexpressed in larval brain compared to embryo and is likely linked to stage specific chromatin modification. To identify the targets of Rad50, ChIPseq with Rad50 antibody was done in duplicate on wandering larval brain and on embryo stage 16.
ORGANISM(S): Drosophila melanogaster 
2024-12-31 | E-MTAB-12982 | biostudies-arrayexpress
TranscriptomicsATAC-seq on rad50∆5.1/rad50∆5.1 and w1118 CNS
Investigate changes in chromatin accessibility in rad50 KO CNS compared to control.
ORGANISM(S): Drosophila melanogaster 
2026-01-01 | E-MTAB-16072 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression during meiosis between wild-type and rad50-deficient strains of Coprinopsis cinerea
Meiosis was compared in rad50-1 and wild type strains of C. cinerea at 6 time points spanning the meiotic timecourse. Abstract: The basidiomycete Coprinopsis cinerea is well-suited to studies of meiosis because meiosis progresses synchronously in ten million cells within each mushroom cap. Approxima...
ORGANISM(S): Coprinopsis cinerea 
2012-05-14 | E-GEOD-37942 | biostudies-arrayexpress
TranscriptomicsGene Expression Profile of Deletion RAD50, MRE11, XRS2
Deletion mutants of the yeast MRX complex (Rad50, Mre11 and Xrs2) were studied for gene expression levels. Significant difference in expression levels was observed in genes pertaining to DNA damage, cell cycle etc. as compared to the BY4741 wild type. Organism : Saccharomyces cerevisiae , Custom Sac...
ORGANISM(S): Saccharomyces cerevisiae 
2015-12-31 | E-GEOD-48538 | biostudies-arrayexpress
GenomicsTrypanosoma brucei VSGseq RAD50 mutants
VSGseq of WT, rad50 and mre11 mutant parasites following induction of a double strand break
PRJEB37290 | ENA
TranscriptomicsMRE11-RAD50-NBS1 activates Fanconi Anemia R-loop suppression at transcription-replication conflicts
Rad50 is a component of the conserved MRE11-RAD50-NBS1 (MRN) complex, which functions in genome stability and the cell’s ability to deal with stalled DNA replication forks. We identified Rad50 as a factor important for R-loop tolerance and thus mapped DNA:RNA hybrids in Rad50KO cells and compare the...
ORGANISM(S): Saccharomyces cerevisiae 
2019-10-31 | E-MTAB-7885 | biostudies-arrayexpress
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