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MetabolomicsTargeting parkin-regulated metabolomic change in cartilage in the treatment of osteoarthritis
Articular cartilage degeneration, which may lead to osteoarthritis (OA), is a normal component of the aging process, but its underlying mechanism remains unknown. We found that chondrocytes exhibited an energy metabolism shift from glycolysis to oxidative phosphorylation (OXPHOS) during aging. Repro...
2024-07-17 | MTBLS9074 | MetaboLights
MetabolomicsTargeting parkin-regulated metabolomic change in cartilage in the treatment of osteoarthritis
Articular cartilage degeneration, which may lead to osteoarthritis (OA), is a normal component of the aging process, but its underlying mechanism remains unknown. We found that chondrocytes exhibited an energy metabolism shift from glycolysis to oxidative phosphorylation (OXPHOS) during aging. Repro...
2024-07-17 | MTBLS9079 | MetaboLights
MetabolomicsLactation-related metabolic mechanism investigated based on mammary gland metabolomics and 4 biofluids’ metabolomics relationships in dairy cows

BACKGROUND: Lactation is extremely important for dairy cows; however, the understanding of the underlying metabolic mechanisms is very limited. This study was conducted to investigate the inherent metabolic patterns during lactation using the overall biofluid metabolomics and the...

2018-03-16 | MTBLS411 | MetaboLights
MetabolomicsMetabolites change reveal insights into the heartwood color formation mechanism of Dalbergia odorifera

Dalbergia odorifera T. Chen, an indigenous species in Hainan Island, China, had high economic and cultural values. Its sapwood was light yellow, while, heartwood was rich in colors of red, yellow, orange and black. The colorful oily deposits were found in the vessels, fibers and par...

2025-08-14 | MTBLS12857 | MetaboLights
MetabolomicsStudy on the mechanism of p-hydroxybenzyl alcohol against OGD/R damage based on metabonomic analysis

Gastrodia elata Blume (GE) has been widely used to treat various central and peripheral nerve diseases, and P-Hydroxybenzaldehyde (PHBA) is one of the indicative components of GE brain protection. Since the previous study of our group found that PHBA has a good effect on protecting mitoc...

2024-07-04 | MTBLS7870 | MetaboLights
MetabolomicsRegulation mechanism of gibberellic acid-3 for astaxanthin biosynthesis in heterotrophically growing Chromochloris zofingiensis

Chromochloris zofingiensis has been proved as a potential resource for large-scale astaxanthin production, but little information of phytohormones on growth and astaxanthin accumulation could be obtained. This study explored the impact of gibberellic acid-3 (GA3) on growth and astaxanthin generat...

2024-08-13 | MTBLS10762 | MetaboLights
MetabolomicsRole and Mechanism of SERPINA1/PLG/TGFB1-Induced Adipose Fibroblast Activation in Dorsal Cervical Adipose Accumulation
This untargeted metabolomics study investigates metabolic differences in human adipose tissue between Group A (n=7) and Group B (n=7). Samples were analyzed using LC-MS/MS in both positive and negative ion modes on a Thermo Q-Exactive HF-X mass spectrometer. A total of 2,305 metabolites were detecte...
2026-05-08 | MTBLS14456 | MetaboLights
MetabolomicsMechanism of terpene formation in Pogostemon cablin cv. Jing Huoxiang revealed by metabolome and transcriptome analysis

Pogostemon cablin (Blanco) Benth. cv. 'Jing Huoxiang', is a valuable medicinal plant widely studied for its aboveground tissues, which are rich in bioactive compounds such as patchouli alcohol. However, systematic investigations into the biosynthesis of sesquiterpenes in its underground parts (ro...

2025-10-12 | MTBLS13122 | MetaboLights
MetabolomicsPhenotypes and Multi—omics Reveal Changes and Molecular Mechanism of Suspension Adaptation of HEK293 Cells Structural Remodelling, Metabolic Reconstruction and Stress Resistance

Human embryonic kidney 293 (HEK293) cells have been successfully adapted from adherent to suspension culture and have been widely applied in both scientific research and the pharmaceutical industry. However, the alterations in cells during the adaptation have not been well described, which raise ...

2025-12-16 | MTBLS13517 | MetaboLights
MetabolomicsProteomics and metabolomics analysis based on exosomes revealed the response mechanism of Alicyclobacillus acidoterrestris to acid stress

Bacteria secrete exosomes containing stress-related molecules such as proteins and nucleic acids, which facilitate adaptation to challenging environments. In order to elucidate the role of A. acidoterrestris exosomes in its acid stress response, this study combined proteomics and metabolomics to ...

2025-09-13 | MTBLS12995 | MetaboLights
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