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MetabolomicsAutomated Label-free Quantification of Metabolites from Liquid Chromatography–Mass Spectrometry Data (Plasma)

Liquid chromatography coupled to mass spectrometry (LC-MS) has become a standard technology in metabolomics. In particular, label-free quantification based on LC-MS is easily amenable to large-scale studies and thus well suited to clinical metabolomics. Large-scale studies, however, require autom...

2015-12-16 | MTBLS234 | MetaboLights
MetabolomicsAutomated Label-free Quantification of Metabolites from Liquid Chromatography–Mass Spectrometry Data (Simulated)

Liquid chromatography coupled to mass spectrometry (LC-MS) has become a standard technology in metabolomics. In particular, label-free quantification based on LC-MS is easily amenable to large-scale studies and thus well suited to clinical metabolomics. Large-scale studies, however, require autom...

2015-12-16 | MTBLS235 | MetaboLights
ProteomicsComparison of LFQ and IPTL for protein identification and relative quantification
Mass spectrometry-based quantitative proteome profiling is most commonly performed by label-free quantification (LFQ), stable isotopic labeling with amino acids in cell culture (SILAC), and reporter-ion based isobaric labeling methods (TMT and iTRAQ). Isobaric peptide termini labeling (IPTL) was des...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD026942 | Pride
Tmt Silac Lfq Quantitative proteomics Iptl 
ProteomicsA metabolic labeling strategy for relative protein quantification in Clostridioides difficile
Clostridioides difficile (formerly Clostridium difficile) is a Gram-positive, spore-forming pathogen which cases drug-induced Clostridioides difficile-associated diseases in hospitals worldwide. A detailed analysis of the proteome may provide new targets for drug development or therapy strategies to...
ORGANISM(S): Peptoclostridium difficile (strain 630) (Clostridium difficile) 
2018-10-25 | PXD010279 | Pride
Proteomics Relative protein quantification Mass spectrometry Metabolic labeling Clostridioides difficile 
ProteomicsMass Dynamics 1.0: A streamlined, web-based environment for analyzing, sharing and integrating Label-Free Data
Label Free Quantification (LFQ) of shotgun proteomics data is a popular and robust method for the characterization of relative protein abundance between samples. Many analytical pipelines exist for the automation of this analysis and some tools exist for the subsequent representation and inspection ...
ORGANISM(S): Homo sapiens (Human) Escherichia coli Saccharomyces cerevisiae (Baker's yeast) 
2022-04-13 | PXD028038 | Pride
Maxquant Benchmarking Label-free quantification Web-based software tool Automated data analysis 
ProteomicsBACE1 KO mouse CSF LC-MSMS - Label-free Quantitative Proteomics of Mouse Cerebrospinal Fluid Detects β-Site APP Cleaving Enzyme (BACE1) Protease Substrates In Vivo
Analysis of murine cerebrospinal fluid (CSF) by quantitative mass spectrometry is challenging due to low CSF volume, low total protein concentration and the presence of highly abundant proteins such as albumin. We demonstrate that the CSF proteome of individual mice can be analyzed in a quantitative...
ORGANISM(S): Mus musculus (Mouse) 
2015-10-12 | PXD001514 | Pride
Mouse csf Csf Label-free quantification 
UnknownA Metabolic Labeling Strategy for Relative Protein Quantification in Clostridioides difficile.
Not available
S-EPMC6198727 | biostudies-literature
UnknownLabel-free Quantification of Proteins in Single Embryonic Cells with Neural Fate in the Cleavage-Stage Frog (Xenopus laevis) Embryo using Capillary Electrophoresis Electrospray Ionization High-Resolution Mass Spectrometry (CE-ESI-HRMS).
Not available
S-EPMC4974349 | biostudies-literature
ProteomicsLabel-free quantitative (LFQ) proteomic analysis of redox mediated posttranslational modifications (PTM) in the cartilage from young and old osteoarthritis (OA) mice with or without the senolytic treatment
Senolytic drugs are designed to selectively clear senescent cells (SnCs) that accumulate with injury or aging. In a mouse model of osteoarthritis (OA), senolysis yields a pro-regenerative response. However, recent research studies showed that the therapeutic benefit is reduced in aged mice. Increase...
ORGANISM(S): Mus musculus (Mouse) 
2023-09-26 | PXD031782 | Pride
Mouse model of osteoarthritis (oa)  senolytic treatment  label-free quantitative (lfq) proteomic  analysis of redox ptms in the cartilage proteins 
ProteomicsTesting TMT-SPS-MS3 and label free approach in recalcitrant Mago (Mangifera indica L.) peel tissues
Significant progress has been observed in recent years in proteomics tools. However, minimal application of the newest proteomic tools has been massively applied in plant recalcitrant tissues in non-model fruits. This constant occurrence constrains the progress in understanding essential molecular p...
ORGANISM(S): Mangifera indica (Mango) 
2024-01-29 | PXD040720 | Pride
Protein extraction Proteomics Postharvest shelf life Mango peel 
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